hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05497.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF2S3 | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | 5 | UniProt NCBI |
| EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | 5 | UniProt NCBI |
| EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5183 | 1.70876175213e-05 | 1.0 | EIF2S3 EIF2S1 | DNA-PK-Ku-eIF2-NF90-NF45 complex |
| WP:WP5027 | 4.4691886917e-05 | 1.0 | EIF2S3 EIF2S1 | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell |
| REAC:R-HSA-72731 | 4.78453290596e-05 | 1.0 | EIF2S3 EIF2S1 | Recycling of eIF2:GDP |
| REAC:R-HSA-9648895 | 0.000155497319444 | 1.0 | EIF2S3 EIF2S1 | Response of EIF2AK1 (HRI) to heme deficiency |
| WP:WP107 | 0.000500549133471 | 1.0 | EIF2S3 EIF2S1 | Translation factors |
| REAC:R-HSA-381042 | 0.00079457421474 | 1.0 | EIF2S3 EIF2S1 | PERK regulates gene expression |
| REAC:R-HSA-72695 | 0.00226581808332 | 1.0 | EIF2S3 EIF2S1 | Formation of the ternary complex, and subsequently, the 43S complex |
| GO:0005850 | 0.0028092043205 | 1.0 | EIF2S3 EIF2S1 | eukaryotic translation initiation factor 2 complex |
| REAC:R-HSA-72702 | 0.00292369135789 | 1.0 | EIF2S3 EIF2S1 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.00292369135789 | 1.0 | EIF2S3 EIF2S1 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.00302450830127 | 1.0 | EIF2S3 EIF2S1 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REAC:R-HSA-381119 | 0.00595674346792 | 1.0 | EIF2S3 EIF2S1 | Unfolded Protein Response (UPR) |
| REAC:R-HSA-382556 | 0.00746899761856 | 1.0 | EIF2S3 EIF2S1 | ABC-family proteins mediated transport |
| REAC:R-HSA-9633012 | 0.00845837067304 | 1.0 | EIF2S3 EIF2S1 | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| REAC:R-HSA-156827 | 0.010244026704 | 1.0 | EIF2S3 EIF2S1 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.0104319904967 | 1.0 | EIF2S3 EIF2S1 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-72737 | 0.0117955823749 | 1.0 | EIF2S3 EIF2S1 | Cap-dependent Translation Initiation |
| REAC:R-HSA-72613 | 0.0117955823749 | 1.0 | EIF2S3 EIF2S1 | Eukaryotic Translation Initiation |
| REAC:R-HSA-9711097 | 0.0198694816538 | 1.0 | EIF2S3 EIF2S1 | Cellular response to starvation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF2S2 | EIF2S1 | 1.0 | 0.946 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| EIF2S3 | EIF2S2 | 1.0 | 0.97 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| EIF2S3 | EIF2S1 | 0.999 | 0.996 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| EIF2S3 | huMAP3_00857.1 huMAP3_05497.1 huMAP3_08129.1 huMAP3_11650.1 huMAP3_15083.1 |
| EIF2S1 | huMAP3_05497.1 huMAP3_08129.1 huMAP3_11650.1 huMAP3_11970.1 |
| EIF2S2 | huMAP3_00857.1 huMAP3_05497.1 huMAP3_08129.1 huMAP3_11650.1 |