hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05511.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDST3 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)] | 5 | UniProt NCBI |
| NDST2 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 2 (EC 2.8.2.-)] | 5 | UniProt NCBI |
| NDST4 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00534 | 6.94780731694e-08 | 1.0 | NDST3 NDST2 NDST4 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
| GO:0015016 | 3.84480164306e-07 | 1.0 | NDST3 NDST2 NDST4 | [heparan sulfate]-glucosamine N-sulfotransferase activity |
| WP:WP5395 | 6.53926343968e-07 | 1.0 | NDST3 NDST2 NDST4 | Glycosaminoglycan synthesis in fibroblasts |
| REAC:R-HSA-2022928 | 1.5285886144e-06 | 1.0 | NDST3 NDST2 NDST4 | HS-GAG biosynthesis |
| GO:0015014 | 5.38272230028e-06 | 1.0 | NDST3 NDST2 NDST4 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process |
| REAC:R-HSA-1638091 | 9.1454019665e-06 | 1.0 | NDST3 NDST2 NDST4 | Heparan sulfate/heparin (HS-GAG) metabolism |
| GO:0034483 | 2.74903317479e-05 | 1.0 | NDST3 NDST2 NDST4 | heparan sulfate sulfotransferase activity |
| WP:WP702 | 3.10835934447e-05 | 1.0 | NDST3 NDST2 NDST4 | Metapathway biotransformation Phase I and II |
| REAC:R-HSA-1630316 | 0.000100702074103 | 1.0 | NDST3 NDST2 NDST4 | Glycosaminoglycan metabolism |
| GO:0015012 | 0.000221076094476 | 1.0 | NDST3 NDST2 NDST4 | heparan sulfate proteoglycan biosynthetic process |
| GO:0019213 | 0.000281151120149 | 1.0 | NDST3 NDST2 NDST4 | deacetylase activity |
| GO:0008146 | 0.000949666005835 | 1.0 | NDST3 NDST2 NDST4 | sulfotransferase activity |
| REAC:R-HSA-71387 | 0.0012894643491 | 1.0 | NDST3 NDST2 NDST4 | Metabolism of carbohydrates |
| GO:0000271 | 0.00155858646605 | 1.0 | NDST3 NDST2 NDST4 | polysaccharide biosynthetic process |
| GO:0030166 | 0.00200169985542 | 1.0 | NDST3 NDST2 NDST4 | proteoglycan biosynthetic process |
| GO:0016782 | 0.00252170927764 | 1.0 | NDST3 NDST2 NDST4 | transferase activity, transferring sulphur-containing groups |
| GO:0006029 | 0.00345936027834 | 1.0 | NDST3 NDST2 NDST4 | proteoglycan metabolic process |
| GO:0005976 | 0.00345936027834 | 1.0 | NDST3 NDST2 NDST4 | polysaccharide metabolic process |
| KEGG:01100 | 0.0189521995452 | 1.0 | NDST3 NDST2 NDST4 | Metabolic pathways |
| GO:0016051 | 0.0328130751425 | 1.0 | NDST3 NDST2 NDST4 | carbohydrate biosynthetic process |
| GO:0044272 | 0.0351938724399 | 1.0 | NDST3 NDST2 NDST4 | sulfur compound biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDST3 | NDST2 | 0.995 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NDST3 | NDST4 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NDST4 | NDST2 | 0.104 | bioplex3_WMM WMM_only |
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