hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05517.1

Complex Portal: CPX-22979

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
H4C1	Histone H4	5	UniProt NCBI
H3C1	Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)	5	UniProt NCBI
CABIN1	Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)	5	UniProt NCBI
UBN2	Ubinuclein-2	3	UniProt NCBI
IPO4	Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)	5	UniProt NCBI
ASF1A	Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)	5	UniProt NCBI
HIRA	Protein HIRA (TUP1-like enhancer of split protein 1)	5	UniProt NCBI
CHAF1A	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150)	5	UniProt NCBI
NASP	Nuclear autoantigenic sperm protein (NASP)	5	UniProt NCBI
ASF1B	Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)	5	UniProt NCBI
TONSL	Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)	5	UniProt NCBI
CHAF1B	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7)	5	UniProt NCBI
UBN1	Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1149	6.34900325421e-17	0.545454545455	ASF1A CHAF1A NASP IPO4 CHAF1B ASF1B	Histone H3.1 complex
CORUM:2235	5.52460635237e-15	0.454545454545	ASF1A ASF1B CHAF1B CHAF1A HIRA	ASF1-interacting protein complex
CORUM:1150	1.15937335921e-13	0.454545454545	ASF1A ASF1B IPO4 NASP HIRA	Histone H3.3 complex
GO:0006334	5.08146369252e-12	0.727272727273	ASF1A CHAF1A NASP CHAF1B CABIN1 UBN1 HIRA ASF1B	nucleosome assembly
GO:0034728	2.47840922108e-11	0.727272727273	ASF1A CHAF1A NASP CHAF1B CABIN1 UBN1 HIRA ASF1B	nucleosome organization
GO:0006335	2.49516293469e-11	0.454545454545	ASF1A ASF1B CHAF1B CHAF1A NASP	DNA replication-dependent chromatin assembly
CORUM:2236	1.72838910881e-10	0.363636363636	ASF1A ASF1B CHAF1B NASP	ASF1-histone containing complex
GO:0065004	1.69791099045e-09	0.727272727273	ASF1A CHAF1A NASP CHAF1B CABIN1 UBN1 HIRA ASF1B	protein-DNA complex assembly
REAC:R-HSA-2559584	6.11535741268e-08	0.363636363636	ASF1A UBN1 CABIN1 HIRA	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
CORUM:7382	8.42140472852e-08	0.272727272727	HIRA CABIN1 UBN1	Prohibitin-HIRA complex
CORUM:7383	8.42140472852e-08	0.272727272727	HIRA CABIN1 UBN1	OGT-HIRA complex
GO:0006338	2.12417045807e-06	0.727272727273	ASF1A CHAF1A NASP CHAF1B CABIN1 UBN1 HIRA ASF1B	chromatin remodeling
GO:0006325	6.31236304959e-06	0.727272727273	ASF1A CHAF1A NASP CHAF1B CABIN1 UBN1 HIRA ASF1B	chromatin organization
GO:0071824	2.03421896456e-05	0.727272727273	ASF1A CHAF1A NASP CHAF1B CABIN1 UBN1 HIRA ASF1B	protein-DNA complex organization
REAC:R-HSA-2559586	3.3660441591e-05	0.363636363636	ASF1A UBN1 CABIN1 HIRA	DNA Damage/Telomere Stress Induced Senescence
CORUM:6149	0.000102551658964	0.181818181818	ASF1A IPO4	Codanin-1-Asf1-histone H3.1-histone H4-importin-4 complex, cytosolic
CORUM:2234	0.000102551658964	0.181818181818	CHAF1B CHAF1A	Chromatin assembly complex (CAF-1 complex)
CORUM:1259	0.000102551658964	0.181818181818	CHAF1B CHAF1A	Chromatin assembly complex (CAF-1 complex)
GO:0042393	0.000163524577629	0.545454545455	ASF1A HIRA NASP TONSL CHAF1B ASF1B	histone binding
REAC:R-HSA-2559583	0.00159038796724	0.363636363636	ASF1A UBN1 CABIN1 HIRA	Cellular Senescence
GO:0000785	0.00256434752378	0.727272727273	ASF1A CHAF1A NASP CHAF1B TONSL IPO4 HIRA ASF1B	chromatin
GO:0032993	0.0040687875558	0.727272727273	ASF1A CHAF1A NASP CHAF1B TONSL IPO4 HIRA ASF1B	protein-DNA complex
GO:0065003	0.0121471648248	0.727272727273	ASF1A CHAF1A NASP CHAF1B CABIN1 UBN1 HIRA ASF1B	protein-containing complex assembly
GO:0005694	0.0433328582986	0.727272727273	ASF1A CHAF1A NASP CHAF1B TONSL IPO4 HIRA ASF1B	chromosome

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CHAF1A	CHAF1B	1.0	0.704
ASF1A	HIRA	1.0	0.086	structurally_consistent (dimer)
HIRA	ASF1B	1.0	0.054	structurally_consistent (dimer)
UBN2	ASF1A	1.0	0.09
CABIN1	ASF1A	1.0	0.032
CHAF1A	H3C1	1.0	0.092
IPO4	ASF1A	0.999	0.05
CHAF1B	H3C1	0.999	0.05	mixed_interface
IPO4	ASF1B	0.999	0.074
CABIN1	HIRA	0.999	0.252
ASF1A	UBN1	0.999	0.07	structurally_consistent (dimer)
H4C1	H3C1	0.999	0.592
UBN2	HIRA	0.998	0.266
NASP	H3C1	0.998
ASF1B	CHAF1B	0.998	0.138	structurally_consistent (P68431) structurally_consistent (dimer)
ASF1B	NASP	0.998		structurally_consistent (dimer)
ASF1A	H3C1	0.998	0.076	structurally_consistent (dimer)
CABIN1	ASF1B	0.997	0.03
UBN2	ASF1B	0.997	0.096
CABIN1	UBN2	0.997	0.174
ASF1B	H4C1	0.997	0.322
ASF1A	H4C1	0.997	0.253392125046	structurally_consistent (dimer)
ASF1B	UBN1	0.997	0.036	structurally_consistent (dimer)
H4C1	NASP	0.997		structurally_consistent (dimer)
TONSL	H4C1	0.996	0.298537142857
CHAF1A	H4C1	0.996	0.271650649666
ASF1B	H3C1	0.995	0.118	structurally_consistent (Q13112) structurally_consistent (dimer)
CHAF1B	H4C1	0.993	0.352073980113	mutually_exclusive (Q9Y294)
ASF1A	NASP	0.993		structurally_consistent (dimer)
ASF1A	ASF1B	0.991	0.136	mutually_exclusive (P49321)
ASF1B	TONSL	0.989	0.15
TONSL	H3C1	0.986	0.034
IPO4	H3C1	0.985	0.168
ASF1A	TONSL	0.984	0.097
HIRA	UBN1	0.975	0.404	mutually_exclusive (Q9Y294)
UBN2	UBN1	0.972	0.094
ASF1B	CHAF1A	0.961	0.124
HIRA	H4C1	0.958	0.681310344828
IPO4	H4C1	0.956	0.441090909091
CHAF1A	NASP	0.949
CABIN1	UBN1	0.884	0.124
HIRA	H3C1	0.873	0.245136363636	mutually_exclusive (Q9Y294)
ASF1A	CHAF1A	0.863	0.112
HIRA	NASP	0.823		mutually_exclusive (Q9NVP2)
TONSL	NASP	0.801
IPO4	HIRA	0.794	0.144
TONSL	CHAF1A	0.738	0.298
CABIN1	H3C1	0.695	0.114
CABIN1	NASP	0.689
IPO4	TONSL	0.656	0.052
IPO4	CHAF1A	0.63	0.09
IPO4	NASP	0.618
UBN2	NASP	0.616
HIRA	CHAF1B	0.59	0.068
UBN1	NASP	0.538		mutually_exclusive (Q9NVP2)
IPO4	CHAF1B	0.525	0.042
TONSL	CHAF1B	0.509	0.172
IPO4	UBN1	0.496	0.06
CABIN1	H4C1	0.474	0.556050941307
UBN2	H4C1	0.466	0.389844035015
ASF1A	CHAF1B	0.446	0.092	mixed_interface
UBN2	H3C1	0.419	0.142
UBN1	H3C1	0.338	0.118	mutually_exclusive (Q9NVP2)
HIRA	CHAF1A	0.333	0.088
TONSL	UBN1	0.263	0.062
CHAF1B	NASP	0.23		mutually_exclusive (Q9NVP2)
HIRA	TONSL	0.226	0.074
CABIN1	CHAF1B	0.198	0.04
UBN1	H4C1	0.182	0.556615384615
CABIN1	TONSL	0.18	0.038
UBN2	TONSL	0.18	0.112
UBN2	CHAF1B	0.175	0.078
UBN1	CHAF1A	0.171	0.0622765957447
CABIN1	IPO4	0.157	0.052
UBN2	CHAF1A	0.151	0.054
CABIN1	CHAF1A	0.151	0.05
UBN1	CHAF1B	0.122	0.068
UBN2	IPO4	0.116	0.066

Related Complexes

Genename	Complexes
H4C1	huMAP3_01440.1 huMAP3_05517.1 huMAP3_05966.1 huMAP3_06020.1 huMAP3_07824.1 huMAP3_08143.1 huMAP3_09048.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10862.1 huMAP3_12711.1
H3C1	huMAP3_03836.1 huMAP3_05517.1 huMAP3_05966.1 huMAP3_07577.1 huMAP3_09048.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10862.1 huMAP3_12711.1
CABIN1	huMAP3_00115.1 huMAP3_00724.1 huMAP3_01912.1 huMAP3_05517.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
UBN2	huMAP3_00115.1 huMAP3_00724.1 huMAP3_01912.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11745.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
IPO4	huMAP3_00115.1 huMAP3_00724.1 huMAP3_03330.1 huMAP3_05068.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09575.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10785.1 huMAP3_12711.1 huMAP3_14135.1 huMAP3_14456.1
ASF1A	huMAP3_00115.1 huMAP3_00724.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
HIRA	huMAP3_00115.1 huMAP3_00724.1 huMAP3_01912.1 huMAP3_05517.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
CHAF1A	huMAP3_01346.1 huMAP3_01440.1 huMAP3_05517.1 huMAP3_05966.1 huMAP3_06469.1 huMAP3_08513.1 huMAP3_09859.1 huMAP3_10512.1 huMAP3_10747.1 huMAP3_11491.1 huMAP3_11539.1 huMAP3_11834.1 huMAP3_12711.1
NASP	huMAP3_01440.1 huMAP3_05517.1 huMAP3_05966.1 huMAP3_06020.1 huMAP3_08143.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_12711.1 huMAP3_12925.1
ASF1B	huMAP3_00115.1 huMAP3_00724.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
TONSL	huMAP3_00115.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_07824.1 huMAP3_08143.1 huMAP3_09466.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10862.1 huMAP3_12711.1 huMAP3_14306.1
CHAF1B	huMAP3_01346.1 huMAP3_02293.1 huMAP3_05517.1 huMAP3_08513.1 huMAP3_10512.1 huMAP3_10747.1 huMAP3_11491.1 huMAP3_11539.1 huMAP3_12711.1
UBN1	huMAP3_00115.1 huMAP3_00724.1 huMAP3_01912.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05517.1

Complex Portal: CPX-22979