hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05532.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ITGA3 | Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] | 5 | UniProt NCBI |
| CACNA2D1 | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] | 5 | UniProt NCBI |
| ITGA2 | Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) | 5 | UniProt NCBI |
| ITGA6 | Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] | 5 | UniProt NCBI |
| ITGA7 | Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form] | 5 | UniProt NCBI |
| CD151 | CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2118 | 1.13301263399e-05 | 0.75 | ITGA3 ITGA7 CACNA2D1 | Arrhythmogenic right ventricular cardiomyopathy |
| CORUM:2395 | 1.53774525569e-05 | 0.5 | ITGA7 CD151 | ITGA7-ITGB1-CD151 complex |
| CORUM:2400 | 1.53774525569e-05 | 0.5 | ITGA3 CD151 | ITGA3-ITGB1-CD151 complex |
| KEGG:05412 | 1.71467161414e-05 | 0.75 | ITGA3 ITGA7 CACNA2D1 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05410 | 2.40425716137e-05 | 0.75 | ITGA3 ITGA7 CACNA2D1 | Hypertrophic cardiomyopathy |
| KEGG:05414 | 2.40425716137e-05 | 0.75 | ITGA3 ITGA7 CACNA2D1 | Dilated cardiomyopathy |
| WP:WP4758 | 0.00169541860832 | 0.5 | ITGA3 CD151 | Nephrotic syndrome |
| WP:WP5348 | 0.00251837499235 | 0.5 | ITGA3 CD151 | 11p11 2 copy number variation syndrome |
| REAC:R-HSA-1474244 | 0.00270393678592 | 0.75 | ITGA3 ITGA7 CD151 | Extracellular matrix organization |
| REAC:R-HSA-3000157 | 0.00359044851421 | 0.5 | ITGA3 ITGA7 | Laminin interactions |
| WP:WP2572 | 0.00480287938686 | 0.5 | ITGA3 CD151 | Primary focal segmental glomerulosclerosis FSGS |
| KEGG:04512 | 0.00551283411821 | 0.5 | ITGA3 ITGA7 | ECM-receptor interaction |
| WP:WP185 | 0.00883615359641 | 0.5 | ITGA3 ITGA7 | Integrin mediated cell adhesion |
| WP:WP4541 | 0.011545786253 | 0.5 | ITGA3 ITGA7 | Hippo Merlin signaling dysregulation |
| REAC:R-HSA-216083 | 0.0199119958937 | 0.5 | ITGA3 ITGA7 | Integrin cell surface interactions |
| CORUM:2320 | 0.0249718442456 | 0.25 | CD151 | ITGA6-ITGB4-CD151 complex |
| KEGG:04510 | 0.03673756538 | 0.5 | ITGA3 ITGA7 | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | ITGA3 ITGA7 | Focal adhesion |
| KEGG:04810 | 0.0466115978004 | 0.5 | ITGA3 ITGA7 | Regulation of actin cytoskeleton |
| CORUM:2406 | 0.049938562206 | 0.25 | ITGA3 | ITGA3-ITGB1 complex |
| CORUM:2401 | 0.049938562206 | 0.25 | ITGA3 | ITGA3-ITGB1-THBS1 complex |
| CORUM:2411 | 0.049938562206 | 0.25 | CD151 | ITGA6-ITGB1-CD151 complex |
| CORUM:2397 | 0.049938562206 | 0.25 | ITGA7 | ITGA7-ITGB1-ITGB1BP3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ITGA3 | ITGA6 | 0.994 | 0.318 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITGA6 | CD151 | 0.992 | 0.104 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ITGA2 | ITGA6 | 0.991 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CACNA2D1 | ITGA6 | 0.988 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITGA7 | ITGA6 | 0.984 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only |
| ITGA3 | ITGA2 | 0.967 | 0.55 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITGA3 | CD151 | 0.961 | 0.168 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| ITGA7 | CD151 | 0.952 | 0.1 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ITGA3 | ITGA7 | 0.951 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
| ITGA2 | ITGA7 | 0.95 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only |
| ITGA3 | CACNA2D1 | 0.936 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITGA7 | CACNA2D1 | 0.882 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
| ITGA2 | CACNA2D1 | 0.649 | 0.184 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITGA2 | CD151 | 0.61 | 0.112 | bioplex3_WMM WMM_only |
| CACNA2D1 | CD151 | 0.023 | 0.058 | bioplex3_WMM WMM_only |
Related Complexes