hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05543.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MYH14 | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | 5 | UniProt NCBI |
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | 5 | UniProt NCBI |
| MYL3 | Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb) | 5 | UniProt NCBI |
| IQGAP2 | Ras GTPase-activating-like protein IQGAP2 | 5 | UniProt NCBI |
| IQGAP1 | Ras GTPase-activating-like protein IQGAP1 (p195) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-195258 | 0.000131735072349 | 0.8 | IQGAP2 MYH14 IQGAP1 MYL6 | RHO GTPase Effectors |
| GO:0015629 | 0.000549054657097 | 1.0 | IQGAP2 MYL3 MYH14 IQGAP1 MYL6 | actin cytoskeleton |
| KEGG:04814 | 0.000638513943056 | 0.6 | MYL3 MYH14 MYL6 | Motor proteins |
| KEGG:04810 | 0.00111331850639 | 0.6 | IQGAP2 MYH14 IQGAP1 | Regulation of actin cytoskeleton |
| GO:0016460 | 0.00169879277018 | 0.6 | MYL3 MYH14 MYL6 | myosin II complex |
| WP:WP4352 | 0.00177296321169 | 0.6 | IQGAP2 MYL6 IQGAP1 | Ciliary landscape |
| REAC:R-HSA-416572 | 0.00259338296865 | 0.4 | MYH14 MYL6 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5625900 | 0.00259338296865 | 0.4 | MYH14 MYL6 | RHO GTPases activate CIT |
| REAC:R-HSA-5627117 | 0.00259338296865 | 0.4 | MYH14 MYL6 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-194315 | 0.00268190833433 | 0.8 | IQGAP2 MYH14 IQGAP1 MYL6 | Signaling by Rho GTPases |
| REAC:R-HSA-5627123 | 0.00288114202251 | 0.4 | MYH14 MYL6 | RHO GTPases activate PAKs |
| REAC:R-HSA-9716542 | 0.00292664866109 | 0.8 | IQGAP2 MYH14 IQGAP1 MYL6 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| WP:WP524 | 0.00309249663983 | 0.4 | IQGAP2 IQGAP1 | G13 signaling pathway |
| REAC:R-HSA-400685 | 0.00383489202506 | 0.4 | MYH14 MYL6 | Sema4D in semaphorin signaling |
| GO:0016459 | 0.00475337188383 | 0.6 | MYL3 MYH14 MYL6 | myosin complex |
| REAC:R-HSA-3928663 | 0.00492422076745 | 0.4 | MYH14 MYL6 | EPHA-mediated growth cone collapse |
| REAC:R-HSA-5626467 | 0.0061489605225 | 0.4 | IQGAP2 IQGAP1 | RHO GTPases activate IQGAPs |
| GO:1902407 | 0.0140440992017 | 0.4 | IQGAP2 IQGAP1 | assembly of actomyosin apparatus involved in mitotic cytokinesis |
| GO:1903475 | 0.0140440992017 | 0.4 | IQGAP2 IQGAP1 | mitotic actomyosin contractile ring assembly |
| GO:1903479 | 0.0140440992017 | 0.4 | IQGAP2 IQGAP1 | mitotic actomyosin contractile ring assembly actin filament organization |
| GO:2000689 | 0.0140440992017 | 0.4 | IQGAP2 IQGAP1 | actomyosin contractile ring assembly actin filament organization |
| KEGG:04270 | 0.0204627079102 | 0.4 | MYH14 MYL6 | Vascular smooth muscle contraction |
| REAC:R-HSA-373755 | 0.0258071378099 | 0.4 | MYH14 MYL6 | Semaphorin interactions |
| GO:0003779 | 0.0306592465565 | 0.8 | IQGAP2 MYH14 IQGAP1 MYL3 | actin binding |
| KEGG:04530 | 0.0427854405203 | 0.4 | MYH14 MYL6 | Tight junction |
| WP:WP51 | 0.046989062869 | 0.4 | IQGAP1 MYL3 | Regulation of actin cytoskeleton |
| REAC:R-HSA-5625740 | 0.0487218825663 | 0.4 | MYH14 MYL6 | RHO GTPases activate PKNs |
| CORUM:1844 | 0.0498708842806 | 0.2 | IQGAP1 | APC-IQGAP1 complex |
| CORUM:6729 | 0.0498708842806 | 0.2 | IQGAP1 | IQGAP1-CXCR2 complex |
| REAC:R-HSA-2682334 | 0.0499330761364 | 0.4 | MYH14 MYL6 | EPH-Ephrin signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MYH14 | MYL6 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| IQGAP2 | MYL6 | 0.995 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| MYL3 | IQGAP1 | 0.992 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| MYL6 | IQGAP1 | 0.991 | 0.252624 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| MYL6 | MYL3 | 0.975 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MYH14 | MYL3 | 0.947 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IQGAP2 | MYH14 | 0.687 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM | |
| IQGAP2 | IQGAP1 | 0.503 | 0.262 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| MYH14 | IQGAP1 | 0.469 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM | |
| IQGAP2 | MYL3 | 0.008 | 0.106 | bioplex3_HEK293 bioplex () |
Related Complexes