hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05551.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IFNA7 | Interferon alpha-7 (IFN-alpha-7) (Interferon alpha-J) (LeIF J) (Interferon alpha-J1) (IFN-alpha-J1) | 5 | UniProt NCBI |
| ISG15 | Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP) | 5 | UniProt NCBI |
| UBA7 | Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (EC 6.2.1.-) (D8) (Ubiquitin-activating enzyme E1 homolog) | 5 | UniProt NCBI |
| IFNA2 | Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-168928 | 1.16721486716e-07 | 1.0 | ISG15 IFNA2 IFNA7 UBA7 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| REAC:R-HSA-913531 | 3.6254700184e-06 | 1.0 | ISG15 IFNA2 IFNA7 UBA7 | Interferon Signaling |
| KEGG:04622 | 1.49470084516e-05 | 0.75 | ISG15 IFNA7 IFNA2 | RIG-I-like receptor signaling pathway |
| WP:WP4655 | 1.52187722416e-05 | 0.75 | ISG15 IFNA7 IFNA2 | Cytosolic DNA sensing pathway |
| REAC:R-HSA-909733 | 5.03512663474e-05 | 0.75 | ISG15 IFNA7 IFNA2 | Interferon alpha/beta signaling |
| REAC:R-HSA-9705671 | 0.00031803083943 | 0.75 | ISG15 IFNA7 IFNA2 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| KEGG:05169 | 0.000325152133201 | 0.75 | ISG15 IFNA7 IFNA2 | Epstein-Barr virus infection |
| KEGG:05171 | 0.000459857531952 | 0.75 | ISG15 IFNA7 IFNA2 | Coronavirus disease - COVID-19 |
| REAC:R-HSA-1280215 | 0.000544985136876 | 1.0 | ISG15 IFNA2 IFNA7 UBA7 | Cytokine Signaling in Immune system |
| WP:WP619 | 0.000894348084449 | 0.5 | ISG15 IFNA2 | Type II interferon signaling |
| WP:WP4912 | 0.00110807642161 | 0.5 | IFNA2 IFNA7 | SARS coronavirus and innate immunity |
| KEGG:05165 | 0.00141764261548 | 0.75 | ISG15 IFNA7 IFNA2 | Human papillomavirus infection |
| REAC:R-HSA-9705683 | 0.00151474987795 | 0.75 | ISG15 IFNA7 IFNA2 | SARS-CoV-2-host interactions |
| WP:WP4558 | 0.00151495259867 | 0.5 | IFNA2 IFNA7 | Overview of interferons mediated signaling pathway |
| KEGG:05320 | 0.00194963326435 | 0.5 | IFNA2 IFNA7 | Autoimmune thyroid disease |
| REAC:R-HSA-168249 | 0.00247124639724 | 1.0 | ISG15 IFNA2 IFNA7 UBA7 | Innate Immune System |
| REAC:R-HSA-912694 | 0.00258893271292 | 0.5 | IFNA2 IFNA7 | Regulation of IFNA/IFNB signaling |
| REAC:R-HSA-933541 | 0.00415229579539 | 0.5 | IFNA2 IFNA7 | TRAF6 mediated IRF7 activation |
| REAC:R-HSA-9694516 | 0.00464100691605 | 0.75 | ISG15 IFNA7 IFNA2 | SARS-CoV-2 Infection |
| REAC:R-HSA-5656169 | 0.00475483947495 | 0.5 | ISG15 UBA7 | Termination of translesion DNA synthesis |
| WP:WP4341 | 0.00495989715897 | 0.5 | ISG15 IFNA2 | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| REAC:R-HSA-936440 | 0.00539805716719 | 0.5 | ISG15 UBA7 | Negative regulators of DDX58/IFIH1 signaling |
| KEGG:04623 | 0.00601982850302 | 0.5 | IFNA2 IFNA7 | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-110313 | 0.00718390333861 | 0.5 | ISG15 UBA7 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| WP:WP75 | 0.00862655865142 | 0.5 | IFNA2 IFNA7 | Toll like receptor signaling pathway |
| WP:WP5095 | 0.00883615359641 | 0.5 | IFNA2 IFNA7 | Overview of proinflammatory and profibrotic mediators |
| KEGG:04620 | 0.00931062778609 | 0.5 | IFNA2 IFNA7 | Toll-like receptor signaling pathway |
| REAC:R-HSA-73893 | 0.0110375739361 | 0.5 | ISG15 UBA7 | DNA Damage Bypass |
| REAC:R-HSA-9679506 | 0.0120967178818 | 0.75 | ISG15 IFNA7 IFNA2 | SARS-CoV Infections |
| KEGG:04650 | 0.014619629343 | 0.5 | IFNA2 IFNA7 | Natural killer cell mediated cytotoxicity |
| GO:0060337 | 0.0159688263229 | 0.75 | ISG15 IFNA7 IFNA2 | type I interferon-mediated signaling pathway |
| GO:0071357 | 0.0167406494658 | 0.75 | ISG15 IFNA7 IFNA2 | cellular response to type I interferon |
| KEGG:04936 | 0.0189154103852 | 0.5 | IFNA2 IFNA7 | Alcoholic liver disease |
| KEGG:05162 | 0.0189154103852 | 0.5 | IFNA2 IFNA7 | Measles |
| WP:WP4630 | 0.01895043011 | 0.5 | IFNA2 IFNA7 | Measles virus infection |
| GO:0034340 | 0.0209740664347 | 0.75 | ISG15 IFNA7 IFNA2 | response to type I interferon |
| KEGG:05160 | 0.0211069184789 | 0.5 | IFNA2 IFNA7 | Hepatitis C |
| KEGG:04630 | 0.0211069184789 | 0.5 | IFNA2 IFNA7 | JAK-STAT signaling pathway |
| REAC:R-HSA-1169408 | 0.0218635493976 | 0.5 | ISG15 UBA7 | ISG15 antiviral mechanism |
| KEGG:04217 | 0.0230797254414 | 0.5 | IFNA2 IFNA7 | Necroptosis |
| WP:WP4666 | 0.023499356813 | 0.5 | IFNA2 IFNA7 | Hepatitis B infection |
| KEGG:05164 | 0.0254912281659 | 0.5 | IFNA2 IFNA7 | Influenza A |
| REAC:R-HSA-1169410 | 0.0260384914588 | 0.5 | ISG15 UBA7 | Antiviral mechanism by IFN-stimulated genes |
| KEGG:05152 | 0.02620193588 | 0.5 | IFNA2 IFNA7 | Tuberculosis |
| KEGG:04621 | 0.02620193588 | 0.5 | IFNA2 IFNA7 | NOD-like receptor signaling pathway |
| KEGG:05161 | 0.0269222811984 | 0.5 | IFNA2 IFNA7 | Hepatitis B |
| REAC:R-HSA-168256 | 0.032293648674 | 1.0 | ISG15 IFNA2 IFNA7 UBA7 | Immune System |
| KEGG:05167 | 0.0346546128597 | 0.5 | IFNA2 IFNA7 | Kaposi sarcoma-associated herpesvirus infection |
| GO:0140888 | 0.0378152735667 | 0.75 | ISG15 IFNA7 IFNA2 | interferon-mediated signaling pathway |
| KEGG:05417 | 0.0397541089323 | 0.5 | IFNA2 IFNA7 | Lipid and atherosclerosis |
| GO:0032020 | 0.042122686785 | 0.5 | ISG15 UBA7 | ISG15-protein conjugation |
| KEGG:05163 | 0.0451972531521 | 0.5 | IFNA2 IFNA7 | Human cytomegalovirus infection |
| KEGG:05170 | 0.0456663239038 | 0.5 | IFNA2 IFNA7 | Human immunodeficiency virus 1 infection |
| KEGG:04060 | 0.0475663770677 | 0.5 | IFNA2 IFNA7 | Cytokine-cytokine receptor interaction |
| CORUM:7046 | 0.049938562206 | 0.25 | IFNA2 | IFNAR2-IFNA2 complex |
| CORUM:7047 | 0.049938562206 | 0.25 | IFNA2 | IFNAR1-IFNAR2-IFNA2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ISG15 | UBA7 | 0.993 | 0.134 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| IFNA2 | ISG15 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IFNA7 | ISG15 | 0.987 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IFNA2 | IFNA7 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes