hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05559.1
Complex Portal: CPX-22684
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ADGRE5 | Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta] | 5 | UniProt NCBI |
| DRAM2 | DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) | 5 | UniProt NCBI |
| ALG6 | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) | 5 | UniProt NCBI |
| TMPPE | Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0060852 | 0.0439037308887 | 0.75 | ALG6 ADGRE5 DRAM2 | bronchus; ciliated cells (cell body)[>=Medium] |
| HPA:0320852 | 0.0466505439721 | 0.75 | ALG6 ADGRE5 DRAM2 | nasopharynx; ciliated cells (cell body)[>=Medium] |
| REAC:R-HSA-4724289 | 0.0499436884912 | 0.25 | ALG6 | Defective ALG6 causes CDG-1c |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ALG6 | ADGRE5 | 0.982 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ADGRE5 | TMPPE | 0.981 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ADGRE5 | DRAM2 | 0.978 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ALG6 | TMPPE | 0.575 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMPPE | DRAM2 | 0.16 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| ALG6 | DRAM2 | 0.123 | 0.154 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes