hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05562.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KCNJ5 | G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5) | 5 | UniProt NCBI |
| KCNJ18 | Inward rectifier potassium channel 18 (Inward rectifier K(+) channel Kir2.6) (Potassium channel, inwardly rectifying subfamily J member 18) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003752 | 3.41752350426e-05 | 1.0 | KCNJ18 KCNJ5 | Episodic flaccid weakness |
| HP:0008153 | 7.17679935894e-05 | 1.0 | KCNJ18 KCNJ5 | Periodic hypokalemic paresis |
| HP:0003768 | 0.000123030846153 | 1.0 | KCNJ18 KCNJ5 | Periodic paralysis |
| HP:0010547 | 0.000266566833332 | 1.0 | KCNJ18 KCNJ5 | Muscle flaccidity |
| KEGG:04921 | 0.00112221860095 | 1.0 | KCNJ18 KCNJ5 | Oxytocin signaling pathway |
| HP:0001657 | 0.00203342648503 | 1.0 | KCNJ18 KCNJ5 | Prolonged QT interval |
| HP:0031547 | 0.00323297723503 | 1.0 | KCNJ18 KCNJ5 | Abnormal QT interval |
| HP:0002900 | 0.00435734246793 | 1.0 | KCNJ18 KCNJ5 | Hypokalemia |
| HP:0001678 | 0.00849254590808 | 1.0 | KCNJ18 KCNJ5 | Atrioventricular block |
| HP:0005150 | 0.00973994198714 | 1.0 | KCNJ18 KCNJ5 | Abnormal atrioventricular conduction |
| HP:0011042 | 0.0102628230833 | 1.0 | KCNJ18 KCNJ5 | Abnormal blood potassium concentration |
| HP:0001962 | 0.0119134869358 | 1.0 | KCNJ18 KCNJ5 | Palpitations |
| HP:0012591 | 0.0130822799743 | 1.0 | KCNJ18 KCNJ5 | Abnormal urinary electrolyte concentration |
| HP:0012722 | 0.0190185183012 | 1.0 | KCNJ18 KCNJ5 | Heart block |
| HP:0003115 | 0.0193807757926 | 1.0 | KCNJ18 KCNJ5 | Abnormal EKG |
| HP:0010930 | 0.0201155433461 | 1.0 | KCNJ18 KCNJ5 | Abnormal blood monovalent inorganic cation concentration |
| HP:0001649 | 0.0216260887349 | 1.0 | KCNJ18 KCNJ5 | Tachycardia |
| HP:0031546 | 0.0277776310426 | 1.0 | KCNJ18 KCNJ5 | Cardiac conduction abnormality |
| HP:0003470 | 0.0318376489657 | 1.0 | KCNJ18 KCNJ5 | Paralysis |
| HP:0004308 | 0.0490927251387 | 1.0 | KCNJ18 KCNJ5 | Ventricular arrhythmia |
| GO:0005242 | 0.0491610756088 | 1.0 | KCNJ18 KCNJ5 | inward rectifier potassium channel activity |
| HP:0005147 | 0.0499436884913 | 0.5 | KCNJ5 | Bidirectional ventricular ectopy |
| HP:0006696 | 0.0499436884913 | 0.5 | KCNJ5 | Polymorphic and polytopic ventricular extrasystoles |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KCNJ5 | KCNJ18 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| KCNJ5 | huMAP3_02913.1 huMAP3_05562.1 huMAP3_06979.1 |
| KCNJ18 | huMAP3_02913.1 huMAP3_05562.1 huMAP3_06979.1 |