hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05564.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | 5 | UniProt NCBI |
| CREB3 | Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)] | 5 | UniProt NCBI |
| CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4] | 5 | UniProt NCBI |
| PDGFC | Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8874211 | 4.91023464396e-08 | 0.75 | CREB3L4 CREB3L3 CREB3 | CREB3 factors activate genes |
| KEGG:05215 | 6.00301532395e-08 | 1.0 | CREB3L4 CREB3L3 PDGFC CREB3 | Prostate cancer |
| WP:WP5272 | 3.38413923581e-07 | 0.75 | CREB3L4 CREB3L3 CREB3 | LDL influence on CD14 and TLR4 |
| WP:WP4756 | 2.08824407225e-06 | 0.75 | CREB3L4 CREB3L3 CREB3 | Renin angiotensin aldosterone system RAAS |
| KEGG:04962 | 3.38522311544e-06 | 0.75 | CREB3L4 CREB3L3 CREB3 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 3.44677262663e-06 | 0.75 | CREB3L4 CREB3L3 CREB3 | Vasopressin regulated water reabsorption |
| KEGG:05030 | 3.65228974203e-06 | 0.75 | CREB3L4 CREB3L3 CREB3 | Cocaine addiction |
| WP:WP3932 | 3.67968103286e-06 | 1.0 | CREB3L4 CREB3L3 PDGFC CREB3 | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:04927 | 3.93303282845e-06 | 0.75 | CREB3L4 CREB3L3 CREB3 | Cortisol synthesis and secretion |
| WP:WP4172 | 5.25751448284e-06 | 1.0 | CREB3L4 CREB3L3 PDGFC CREB3 | PI3K Akt signaling pathway |
| KEGG:04151 | 6.41284406676e-06 | 1.0 | CREB3L4 CREB3L3 PDGFC CREB3 | PI3K-Akt signaling pathway |
| KEGG:05031 | 1.00167038843e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Amphetamine addiction |
| KEGG:04918 | 1.17128735206e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Thyroid hormone synthesis |
| WP:WP45 | 1.4517114839e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | G1 to S cell cycle control |
| KEGG:04911 | 1.49470084516e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Insulin secretion |
| KEGG:04925 | 2.21720662311e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Aldosterone synthesis and secretion |
| KEGG:04211 | 2.91718888289e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Longevity regulating pathway |
| KEGG:04928 | 3.1411932255e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04916 | 3.1411932255e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Melanogenesis |
| KEGG:04725 | 3.88128290779e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Cholinergic synapse |
| WP:WP4321 | 4.22705434747e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Thermogenesis |
| KEGG:04915 | 4.29129056473e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Estrogen signaling pathway |
| KEGG:04922 | 4.29129056473e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Glucagon signaling pathway |
| KEGG:04668 | 4.7291535364e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | TNF signaling pathway |
| KEGG:04931 | 5.19578118732e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Insulin resistance |
| KEGG:04935 | 5.52329547577e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Growth hormone synthesis, secretion and action |
| KEGG:04926 | 6.9706157818e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Relaxin signaling pathway |
| KEGG:04728 | 7.16752745545e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Dopaminergic synapse |
| KEGG:04152 | 7.99217742683e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | AMPK signaling pathway |
| KEGG:04261 | 9.34385249616e-05 | 0.75 | CREB3L4 CREB3L3 CREB3 | Adrenergic signaling in cardiomyocytes |
| KEGG:04022 | 0.000108396031683 | 0.75 | CREB3L4 CREB3L3 CREB3 | cGMP-PKG signaling pathway |
| KEGG:04934 | 0.000108396031683 | 0.75 | CREB3L4 CREB3L3 CREB3 | Cushing syndrome |
| REAC:R-HSA-381119 | 0.000133147800117 | 0.75 | CREB3L4 CREB3L3 CREB3 | Unfolded Protein Response (UPR) |
| WP:WP4666 | 0.000145521073611 | 0.75 | CREB3L4 CREB3L3 CREB3 | Hepatitis B infection |
| KEGG:05161 | 0.000180381602802 | 0.75 | CREB3L4 CREB3L3 CREB3 | Hepatitis B |
| KEGG:05034 | 0.000184078554429 | 0.75 | CREB3L4 CREB3L3 CREB3 | Alcoholism |
| KEGG:04024 | 0.000219642829889 | 0.75 | CREB3L4 CREB3L3 CREB3 | cAMP signaling pathway |
| KEGG:05207 | 0.000241241390361 | 0.75 | CREB3L4 CREB3L3 CREB3 | Chemical carcinogenesis - receptor activation |
| KEGG:05203 | 0.000358846380147 | 0.75 | CREB3L4 CREB3L3 CREB3 | Viral carcinogenesis |
| KEGG:05163 | 0.000394783718861 | 0.75 | CREB3L4 CREB3L3 CREB3 | Human cytomegalovirus infection |
| KEGG:05166 | 0.000433035444638 | 0.75 | CREB3L4 CREB3L3 CREB3 | Human T-cell leukemia virus 1 infection |
| KEGG:04714 | 0.000480682574607 | 0.75 | CREB3L4 CREB3L3 CREB3 | Thermogenesis |
| KEGG:05020 | 0.000820802302251 | 0.75 | CREB3L4 CREB3L3 CREB3 | Prion disease |
| KEGG:05016 | 0.00111064292822 | 0.75 | CREB3L4 CREB3L3 CREB3 | Huntington disease |
| KEGG:05165 | 0.00141764261548 | 0.75 | CREB3L4 CREB3L3 CREB3 | Human papillomavirus infection |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CREB3 | PDGFC | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CREB3L3 | CREB3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L3 | CREB3L4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3 | CREB3L4 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CREB3L4 | PDGFC | 0.904 | bioplex3_WMM WMM_only |
Related Complexes