hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05572.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GMPPB | Mannose-1-phosphate guanyltransferase beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) | 5 | UniProt NCBI |
| GMPPA | Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) | 5 | UniProt NCBI |
| ST3GAL1 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A) | 5 | UniProt NCBI |
| GOLPH3L | Golgi phosphoprotein 3-like (GPP34-related protein) | 5 | UniProt NCBI |
| GOLPH3 | Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446219 | 9.57519237992e-05 | 0.6 | GMPPB ST3GAL1 GMPPA | Synthesis of substrates in N-glycan biosythesis |
| REAC:R-HSA-446205 | 0.000151950811602 | 0.4 | GMPPB GMPPA | Synthesis of GDP-mannose |
| REAC:R-HSA-446193 | 0.000192707923335 | 0.6 | GMPPB ST3GAL1 GMPPA | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| KEGG:00051 | 0.00253895212354 | 0.4 | GMPPB GMPPA | Fructose and mannose metabolism |
| KEGG:01250 | 0.00269245905375 | 0.4 | GMPPB GMPPA | Biosynthesis of nucleotide sugars |
| KEGG:00520 | 0.00447375439216 | 0.4 | GMPPB GMPPA | Amino sugar and nucleotide sugar metabolism |
| WP:WP5153 | 0.00744927604553 | 0.4 | GMPPB GMPPA | N glycan biosynthesis |
| GO:0031985 | 0.0094606249379 | 0.6 | ST3GAL1 GOLPH3L GOLPH3 | Golgi cisterna |
| REAC:R-HSA-446203 | 0.0113314618617 | 0.6 | GMPPB ST3GAL1 GMPPA | Asparagine N-linked glycosylation |
| GO:0005795 | 0.0310683011928 | 0.6 | ST3GAL1 GOLPH3L GOLPH3 | Golgi stack |
| KEGG:01240 | 0.0397793006284 | 0.4 | GMPPB GMPPA | Biosynthesis of cofactors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GMPPA | GMPPB | 1.0 | 0.838 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| GMPPA | GOLPH3 | 0.997 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GMPPB | GOLPH3 | 0.984 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GOLPH3 | GOLPH3L | 0.965 | 0.892 | bioplex_WMM bioplex3_WMM WMM_only |
| ST3GAL1 | GOLPH3 | 0.964 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ST3GAL1 | GOLPH3L | 0.732 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GMPPA | ST3GAL1 | 0.015 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GMPPA | GOLPH3L | 0.003 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes