hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05575.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNASEH2C | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | 5 | UniProt NCBI |
| RNASEH2A | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | 5 | UniProt NCBI |
| CEP164 | Centrosomal protein of 164 kDa (Cep164) | 5 | UniProt NCBI |
| RNASEH2B | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4705 | 1.2715614816e-07 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Pathways of nucleic acid metabolism and innate immune sensing |
| HP:0009709 | 2.5625432796e-07 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Increased CSF interferon alpha |
| HP:0009704 | 2.5625432796e-07 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Chronic CSF lymphocytosis |
| HP:0009710 | 3.84361757466e-07 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Chilblains |
| GO:0032299 | 3.84480164306e-07 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | ribonuclease H2 complex |
| HP:0004809 | 7.54918781021e-07 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Neonatal alloimmune thrombocytopenia |
| HP:0040140 | 7.54918781021e-07 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Degeneration of the striatum |
| HP:0007052 | 1.30839150474e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Multifocal cerebral white matter abnormalities |
| HP:0005550 | 1.30839150474e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Chronic lymphatic leukemia |
| HP:0011834 | 1.66514003543e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Moyamoya phenomenon |
| HP:0007076 | 1.66514003543e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Extrapyramidal muscular rigidity |
| HP:0001955 | 2.08131814923e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Unexplained fevers |
| KEGG:03030 | 2.44690940764e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | DNA replication |
| HP:0200149 | 3.11022189932e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | CSF lymphocytic pleiocytosis |
| HP:0004963 | 3.73207457287e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Calcification of the aorta |
| HP:0030356 | 3.73207457287e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Increased circulating interferon-gamma concentration |
| HP:0030038 | 5.21339206211e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Enchondroma |
| HP:0012229 | 6.08197827663e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | CSF pleocytosis |
| HP:0005558 | 6.08197827663e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Chronic leukemia |
| HP:0030355 | 7.04192883742e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal circulating interferon-gamma concentration |
| HP:0030354 | 7.04192883742e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal circulating interferon concentration |
| HP:0003207 | 9.25415545838e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Arterial calcification |
| HP:0012490 | 9.25415545838e-06 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Panniculitis |
| HP:0004934 | 1.33716561973e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Vascular calcification |
| HP:0002132 | 1.6702567458e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Porencephalic cyst |
| HP:0011112 | 2.05446971161e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormality of serum cytokine level |
| HP:0001063 | 2.05446971161e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Acrocyanosis |
| HP:0100614 | 2.26688453372e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Myositis |
| HP:0011915 | 2.26688453372e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Cardiovascular calcification |
| HP:0011111 | 2.26688453372e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormality of immune serum protein physiology |
| HP:0000625 | 2.26688453372e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Eyelid coloboma |
| HP:0034033 | 2.49344480699e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Peripheral cyanosis |
| HP:0002139 | 2.49344480699e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Arrhinencephaly |
| HP:0011226 | 4.17532321542e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Aplasia/Hypoplasia of the eyelid |
| HP:0010994 | 4.51363082059e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal corpus striatum morphology |
| HP:0030880 | 4.86971965604e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Raynaud phenomenon |
| HP:0002371 | 8.41302083589e-05 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Loss of speech |
| HP:0007108 | 0.000106949015958 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Demyelinating peripheral neuropathy |
| HP:0002313 | 0.000113234307236 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Spastic paraparesis |
| HP:0002910 | 0.000126070327541 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Elevated hepatic transaminase |
| HP:0006579 | 0.000133556051791 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Prolonged neonatal jaundice |
| HP:0002828 | 0.000164241035467 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Multiple joint contractures |
| HP:0000965 | 0.000208772859528 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Cutis marmorata |
| HP:0001087 | 0.000228622881885 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Developmental glaucoma |
| HP:0100578 | 0.000228622881885 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Lipoatrophy |
| HP:0009145 | 0.000249691267079 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal cerebral artery morphology |
| HP:0002385 | 0.000295627549748 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Paraparesis |
| HP:0003552 | 0.000295627549748 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Muscle stiffness |
| HP:0002180 | 0.000295627549748 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Neurodegeneration |
| HP:0000444 | 0.000360544079166 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Convex nasal ridge |
| HP:0000961 | 0.000517504387705 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Cyanosis |
| HP:0002415 | 0.000610673070958 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Leukodystrophy |
| HP:0002187 | 0.000650860682772 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Intellectual disability, profound |
| HP:0010622 | 0.000671598193523 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Neoplasm of the skeletal system |
| HP:0001609 | 0.000671598193523 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Hoarse voice |
| HP:0002510 | 0.000878354456144 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Spastic tetraplegia |
| HP:0012379 | 0.000957971691184 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormal circulating enzyme concentration or activity |
| HP:0009125 | 0.00103738630957 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Lipodystrophy |
| HP:0001640 | 0.00115339437847 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Cardiomegaly |
| HP:0002514 | 0.00121450179964 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Cerebral calcification |
| HP:0034221 | 0.00124584699949 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal temporal lobe morphology |
| HP:0034684 | 0.0013442189742 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormal enzyme concentration or activity |
| GO:0006298 | 0.00140301566648 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | mismatch repair |
| HP:0025454 | 0.00174274034998 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal CSF metabolite concentration |
| HP:0001357 | 0.00182297680205 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Plagiocephaly |
| HP:0001433 | 0.00182297680205 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Hepatosplenomegaly |
| HP:0004942 | 0.00199074487028 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Aortic aneurysm |
| HP:0100021 | 0.00230848648861 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Cerebral palsy |
| HP:0025323 | 0.00240508803736 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal arterial physiology |
| HP:0000958 | 0.00250434060906 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Dry skin |
| HP:0001909 | 0.00271094083935 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Leukemia |
| HP:0002134 | 0.00339805584354 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal basal ganglia morphology |
| HP:0410042 | 0.00396695807199 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormal liver morphology |
| HP:0000952 | 0.00405200286793 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Jaundice |
| HP:0001369 | 0.00419209128786 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Arthritis |
| HP:0002063 | 0.00426332656788 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Rigidity |
| HP:0002617 | 0.00455631106303 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Vascular dilatation |
| HP:0010766 | 0.00526378291815 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Ectopic calcification |
| HP:0010551 | 0.00526378291815 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Paraplegia/paraparesis |
| HP:0004374 | 0.0058618765749 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Hemiplegia/hemiparesis |
| HP:0002061 | 0.00613143375936 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Lower limb spasticity |
| HP:0009124 | 0.00719009671515 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal adipose tissue morphology |
| HP:0011119 | 0.00729194720183 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal nasal dorsum morphology |
| HP:0002960 | 0.00803184965878 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Autoimmunity |
| HP:0000054 | 0.00847621018071 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Micropenis |
| HP:0000639 | 0.00869731190808 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Nystagmus |
| HP:0001396 | 0.00905423426659 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Cholestasis |
| HP:0012547 | 0.00924904195908 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormal involuntary eye movements |
| HP:0001392 | 0.00953454865728 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormality of the liver |
| HP:0000737 | 0.0100325283905 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Irritability |
| HP:0001639 | 0.0120511721551 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Hypertrophic cardiomyopathy |
| HP:0002355 | 0.0130788400566 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Difficulty walking |
| HP:0004377 | 0.0135364936749 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Hematological neoplasm |
| HP:0001005 | 0.0138474242728 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Dermatological manifestations of systemic disorders |
| HP:0002071 | 0.0140046510202 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormality of extrapyramidal motor function |
| HP:0030163 | 0.0158129816731 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal vascular physiology |
| HP:0008936 | 0.0168615855136 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Axial hypotonia |
| HP:0002315 | 0.0170407149806 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Headache |
| HP:0007700 | 0.0172211022813 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Ocular anterior segment dysgenesis |
| HP:0100659 | 0.0198810095864 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal cerebral vascular morphology |
| HP:0004328 | 0.0202092954763 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormal anterior eye segment morphology |
| HP:0002012 | 0.0205007275068 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormality of the abdominal organs |
| HP:0000501 | 0.022366775962 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Glaucoma |
| HP:0000821 | 0.0241334081412 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Hypothyroidism |
| HP:0004297 | 0.0255174052948 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormality of the biliary system |
| HP:0011025 | 0.0257797800958 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormal cardiovascular system physiology |
| HP:0004322 | 0.0263940803883 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Short stature |
| HP:0002926 | 0.0274431881859 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormality of thyroid physiology |
| HP:0001679 | 0.0292052421452 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal aortic morphology |
| HP:0001945 | 0.0297221025438 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Fever |
| HP:0034353 | 0.0305087012549 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Appendicular spasticity |
| HP:0008736 | 0.0305087012549 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Hypoplasia of penis |
| HP:0001873 | 0.0318501377451 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Thrombocytopenia |
| HP:0011400 | 0.0352277122971 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal CNS myelination |
| HP:0000002 | 0.0361997133303 | 1.0 | RNASEH2B RNASEH2A RNASEH2C CEP164 | Abnormality of body height |
| HP:0002376 | 0.0367022439828 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Developmental regression |
| HP:0011873 | 0.0397727710244 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal platelet count |
| HP:0011875 | 0.0407260045359 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal platelet morphology |
| HP:0007256 | 0.0416942448541 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormal pyramidal sign |
| HP:0001744 | 0.0423481317849 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Splenomegaly |
| HP:0000819 | 0.0423481317849 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Diabetes mellitus |
| HP:0001608 | 0.0426776059203 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormality of the voice |
| HP:0001952 | 0.0450315574533 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Glucose intolerance |
| HP:0011123 | 0.046066142944 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Inflammatory abnormality of the skin |
| HP:0001872 | 0.0478252050842 | 0.75 | RNASEH2A RNASEH2C RNASEH2B | Abnormality of thrombocytes |
| CORUM:6519 | 0.049938562206 | 0.25 | CEP164 | CCDC92-CEP164 complex |
| CORUM:6518 | 0.049938562206 | 0.25 | CEP164 | CEP164-TTBK2 complex |
| CORUM:6531 | 0.049938562206 | 0.25 | CEP164 | CEP164-DZIP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNASEH2C | RNASEH2A | 0.999 | 0.72 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 fraction |
| RNASEH2C | RNASEH2B | 0.999 | 0.366 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 fraction |
| RNASEH2A | RNASEH2B | 0.996 | 0.652 | hein_WMM bioplex3_WMM hein () fraction |
| RNASEH2A | CEP164 | 0.972 | 0.17 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RNASEH2B | CEP164 | 0.4 | 0.078 | hein_WMM hein () |
| RNASEH2C | CEP164 | 0.063 | 0.124 | hein_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RNASEH2C | huMAP3_00460.1 huMAP3_05575.1 |
| RNASEH2A | huMAP3_00460.1 huMAP3_01583.1 huMAP3_05575.1 huMAP3_09404.1 huMAP3_10079.1 |
| CEP164 | huMAP3_01583.1 huMAP3_05575.1 huMAP3_08758.1 huMAP3_09374.1 huMAP3_09404.1 huMAP3_10079.1 huMAP3_14935.1 |
| RNASEH2B | huMAP3_00460.1 huMAP3_05575.1 |