hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05581.1
Complex Portal: CPX-22633
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRTAP | Cartilage-associated protein | 5 | UniProt NCBI |
| P3H2 | Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4) | 5 | UniProt NCBI |
| P3H1 | Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) | 5 | UniProt NCBI |
| VPS37D | Vacuolar protein sorting-associated protein 37D (ESCRT-I complex subunit VPS37D) (Williams-Beuren syndrome chromosomal region 24 protein) | 5 | UniProt NCBI |
| EDA | Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form] | 5 | UniProt NCBI |
| TOR4A | Torsin-4A (Torsin family 4 member A) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4786 | 1.23443185531e-05 | 0.5 | CRTAP P3H2 P3H1 | Type I collagen synthesis in the context of osteogenesis imperfecta |
| REAC:R-HSA-1650814 | 0.000155019643237 | 0.5 | CRTAP P3H2 P3H1 | Collagen biosynthesis and modifying enzymes |
| HP:3000050 | 0.00036179605176 | 0.666666666667 | CRTAP EDA VPS37D P3H1 | Abnormal odontoid tissue morphology |
| REAC:R-HSA-1474290 | 0.000417052782963 | 0.5 | CRTAP P3H2 P3H1 | Collagen formation |
| HP:0008796 | 0.000648041335154 | 0.333333333333 | CRTAP P3H1 | Femoral retroversion |
| HP:0011061 | 0.00204945939855 | 0.666666666667 | CRTAP EDA VPS37D P3H1 | Abnormality of dental structure |
| HP:0031069 | 0.00302198579101 | 0.333333333333 | CRTAP P3H1 | Abnormal femoral torsion |
| REAC:R-HSA-1474244 | 0.0133066815994 | 0.5 | CRTAP P3H2 P3H1 | Extracellular matrix organization |
| HP:0005474 | 0.0146541203169 | 0.333333333333 | CRTAP P3H1 | Decreased calvarial ossification |
| HP:0005855 | 0.0146541203169 | 0.333333333333 | CRTAP P3H1 | Multiple prenatal fractures |
| HP:0000703 | 0.0164828756284 | 0.333333333333 | CRTAP P3H1 | Dentinogenesis imperfecta |
| HP:0010299 | 0.020461457105 | 0.333333333333 | CRTAP P3H1 | Abnormal dentin morphology |
| GO:0019797 | 0.0210651876021 | 0.333333333333 | P3H1 P3H2 | procollagen-proline 3-dioxygenase activity |
| HP:0000682 | 0.0288997454362 | 0.5 | CRTAP VPS37D EDA | Abnormal dental enamel morphology |
| HP:0002979 | 0.0405591774535 | 0.5 | CRTAP VPS37D P3H1 | Bowing of the legs |
| GO:0031544 | 0.042122686785 | 0.333333333333 | P3H1 P3H2 | peptidyl-proline 3-dioxygenase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CRTAP | P3H1 | 1.0 | 0.94 |
mutually_exclusive (Q8IVL5)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| CRTAP | P3H2 | 0.998 | 0.062 |
mutually_exclusive (Q32P28)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| P3H2 | P3H1 | 0.998 | 0.018 |
mutually_exclusive (O75718)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| EDA | P3H2 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| P3H1 | VPS37D | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EDA | CRTAP | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CRTAP | VPS37D | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EDA | P3H1 | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TOR4A | P3H1 | 0.96 | 0.058 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CRTAP | TOR4A | 0.473 | 0.096 | bioplex3_WMM WMM_only | |
| EDA | TOR4A | 0.016 | bioplex3_WMM WMM_only |
Related Complexes