hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05596.1
Complex Portal: CPX-17175
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBR5 | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | 5 | UniProt NCBI |
| HUWE1 | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | 5 | UniProt NCBI |
| TANGO6 | Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04120 | 0.00686279305854 | 0.666666666667 | HUWE1 UBR5 | Ubiquitin mediated proteolysis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TANGO6 | UBR5 | 0.954 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBR5 | HUWE1 | 0.951 | bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM | ||
| TANGO6 | HUWE1 | 0.403 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| UBR5 | huMAP3_03911.1 huMAP3_05596.1 huMAP3_10577.1 |
| HUWE1 | huMAP3_03911.1 huMAP3_05596.1 huMAP3_10577.1 huMAP3_13407.1 |
| TANGO6 | huMAP3_01311.1 huMAP3_01335.1 huMAP3_05029.1 huMAP3_05596.1 huMAP3_05710.1 huMAP3_10363.1 huMAP3_10441.1 |