hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05612.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PYCR3 | Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein) | 5 | UniProt NCBI |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | 5 | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8964539 | 7.69893532894e-08 | 1.0 | PYCR1 PYCR3 PYCR2 | Glutamate and glutamine metabolism |
| GO:0004735 | 3.84480164306e-07 | 1.0 | PYCR1 PYCR3 PYCR2 | pyrroline-5-carboxylate reductase activity |
| GO:0055129 | 3.84480164306e-07 | 1.0 | PYCR1 PYCR3 PYCR2 | L-proline biosynthetic process |
| KEGG:00330 | 6.44683384198e-07 | 1.0 | PYCR1 PYCR3 PYCR2 | Arginine and proline metabolism |
| GO:0006561 | 9.61200410764e-07 | 1.0 | PYCR1 PYCR3 PYCR2 | proline biosynthetic process |
| KEGG:01230 | 2.50251661292e-06 | 1.0 | PYCR1 PYCR3 PYCR2 | Biosynthesis of amino acids |
| GO:0006560 | 8.07408345042e-06 | 1.0 | PYCR1 PYCR3 PYCR2 | proline metabolic process |
| GO:0016646 | 3.49876949518e-05 | 1.0 | PYCR1 PYCR3 PYCR2 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| GO:0009084 | 4.37346186898e-05 | 1.0 | PYCR1 PYCR3 PYCR2 | glutamine family amino acid biosynthetic process |
| GO:0016645 | 9.31403198031e-05 | 1.0 | PYCR1 PYCR3 PYCR2 | oxidoreductase activity, acting on the CH-NH group of donors |
| WP:WP497 | 0.000237669979309 | 0.666666666667 | PYCR1 PYCR3 | Urea cycle and metabolism of amino groups |
| WP:WP4290 | 0.000837946224705 | 0.666666666667 | PYCR1 PYCR2 | Metabolic reprogramming in colon cancer |
| GO:0170038 | 0.000949666005835 | 1.0 | PYCR1 PYCR3 PYCR2 | proteinogenic amino acid biosynthetic process |
| GO:0170034 | 0.00102463963787 | 1.0 | PYCR1 PYCR3 PYCR2 | L-amino acid biosynthetic process |
| GO:0009064 | 0.00145910222354 | 1.0 | PYCR1 PYCR3 PYCR2 | glutamine family amino acid metabolic process |
| GO:0008652 | 0.00145910222354 | 1.0 | PYCR1 PYCR3 PYCR2 | amino acid biosynthetic process |
| GO:1901607 | 0.0018839528051 | 1.0 | PYCR1 PYCR3 PYCR2 | alpha-amino acid biosynthetic process |
| REAC:R-HSA-71291 | 0.00257220962738 | 1.0 | PYCR1 PYCR3 PYCR2 | Metabolism of amino acids and derivatives |
| GO:0170039 | 0.0101882437539 | 1.0 | PYCR1 PYCR3 PYCR2 | proteinogenic amino acid metabolic process |
| GO:0170033 | 0.0124731132503 | 1.0 | PYCR1 PYCR3 PYCR2 | L-amino acid metabolic process |
| KEGG:01100 | 0.0189521995452 | 1.0 | PYCR1 PYCR3 PYCR2 | Metabolic pathways |
| GO:1901605 | 0.042099520671 | 1.0 | PYCR1 PYCR3 PYCR2 | alpha-amino acid metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PYCR2 | PYCR1 | 1.0 | 0.416 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| PYCR2 | PYCR3 | 0.999 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PYCR1 | PYCR3 | 0.992 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
Related Complexes