hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05615.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASP7 | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | 5 | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111459 | 1.70876175213e-05 | 1.0 | CASP7 XIAP | Activation of caspases through apoptosome-mediated cleavage |
| REAC:R-HSA-111469 | 2.56314262819e-05 | 1.0 | CASP7 XIAP | SMAC, XIAP-regulated apoptotic response |
| REAC:R-HSA-111463 | 2.56314262819e-05 | 1.0 | CASP7 XIAP | SMAC (DIABLO) binds to IAPs |
| REAC:R-HSA-111464 | 2.56314262819e-05 | 1.0 | CASP7 XIAP | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |
| KEGG:04215 | 6.60032959562e-05 | 1.0 | CASP7 XIAP | Apoptosis - multiple species |
| REAC:R-HSA-111461 | 0.000112778275641 | 1.0 | CASP7 XIAP | Cytochrome c-mediated apoptotic response |
| WP:WP1433 | 0.000138332030934 | 1.0 | CASP7 XIAP | Nucleotide binding oligomerization domain NOD pathway |
| REAC:R-HSA-111471 | 0.00023239159829 | 1.0 | CASP7 XIAP | Apoptotic factor-mediated response |
| KEGG:04668 | 0.000725873685824 | 1.0 | CASP7 XIAP | TNF signaling pathway |
| WP:WP254 | 0.00111857408398 | 1.0 | CASP7 XIAP | Apoptosis |
| KEGG:04210 | 0.00116074761854 | 1.0 | CASP7 XIAP | Apoptosis |
| WP:WP1772 | 0.00127818796583 | 1.0 | CASP7 XIAP | Apoptosis modulation and signaling |
| WP:WP5090 | 0.0016667945635 | 1.0 | CASP7 XIAP | Complement system in neuronal development and plasticity |
| REAC:R-HSA-109606 | 0.00226581808332 | 1.0 | CASP7 XIAP | Intrinsic Pathway for Apoptosis |
| KEGG:05200 | 0.0161326036311 | 1.0 | CASP7 XIAP | Pathways in cancer |
| REAC:R-HSA-109581 | 0.0234014921954 | 1.0 | CASP7 XIAP | Apoptosis |
| REAC:R-HSA-5357801 | 0.0319897287616 | 1.0 | CASP7 XIAP | Programmed Cell Death |
| CORUM:6292 | 0.0499419797295 | 0.5 | XIAP | HAX-1-XIAP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CASP7 | XIAP | 0.987 | 0.21 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
Related Complexes