hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05634.1
Complex Portal: CPX-19766
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NSUN5 | 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) | 5 | UniProt NCBI |
| PYCR3 | Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein) | 5 | UniProt NCBI |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | 5 | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8964539 | 2.31434954766e-07 | 0.75 | PYCR2 PYCR3 PYCR1 | Glutamate and glutamine metabolism |
| GO:0004735 | 1.53784171933e-06 | 0.75 | PYCR2 PYCR3 PYCR1 | pyrroline-5-carboxylate reductase activity |
| GO:0055129 | 1.53784171933e-06 | 0.75 | PYCR2 PYCR3 PYCR1 | L-proline biosynthetic process |
| GO:0006561 | 3.84440695359e-06 | 0.75 | PYCR2 PYCR3 PYCR1 | proline biosynthetic process |
| KEGG:00330 | 4.22779284136e-06 | 0.75 | PYCR2 PYCR3 PYCR1 | Arginine and proline metabolism |
| KEGG:01230 | 1.63910874597e-05 | 0.75 | PYCR2 PYCR3 PYCR1 | Biosynthesis of amino acids |
| GO:0006560 | 3.22863876272e-05 | 0.75 | PYCR2 PYCR3 PYCR1 | proline metabolic process |
| GO:0016646 | 0.000139871762976 | 0.75 | PYCR2 PYCR3 PYCR1 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| GO:0009084 | 0.000174830724535 | 0.75 | PYCR2 PYCR3 PYCR1 | glutamine family amino acid biosynthetic process |
| GO:0016645 | 0.000372255315939 | 0.75 | PYCR2 PYCR3 PYCR1 | oxidoreductase activity, acting on the CH-NH group of donors |
| WP:WP497 | 0.000535373329556 | 0.5 | PYCR1 PYCR3 | Urea cycle and metabolism of amino groups |
| WP:WP4290 | 0.00188599942343 | 0.5 | PYCR2 PYCR1 | Metabolic reprogramming in colon cancer |
| GO:0170038 | 0.0037914498893 | 0.75 | PYCR2 PYCR3 PYCR1 | proteinogenic amino acid biosynthetic process |
| GO:0170034 | 0.00409056451107 | 0.75 | PYCR2 PYCR3 PYCR1 | L-amino acid biosynthetic process |
| GO:0009064 | 0.00582352741409 | 0.75 | PYCR2 PYCR3 PYCR1 | glutamine family amino acid metabolic process |
| GO:0008652 | 0.00582352741409 | 0.75 | PYCR2 PYCR3 PYCR1 | amino acid biosynthetic process |
| GO:1901607 | 0.00751763182363 | 0.75 | PYCR2 PYCR3 PYCR1 | alpha-amino acid biosynthetic process |
| REAC:R-HSA-71291 | 0.007608748274 | 0.75 | PYCR2 PYCR3 PYCR1 | Metabolism of amino acids and derivatives |
| GO:0170039 | 0.0405772675542 | 0.75 | PYCR2 PYCR3 PYCR1 | proteinogenic amino acid metabolic process |
| GO:0170033 | 0.0496619752722 | 0.75 | PYCR2 PYCR3 PYCR1 | L-amino acid metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PYCR2 | PYCR1 | 1.0 | 0.416 |
mutually_exclusive (Q53H96)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| PYCR2 | PYCR3 | 0.999 | 0.032 |
mutually_exclusive (P32322)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PYCR1 | PYCR3 | 0.992 | 0.094 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
| NSUN5 | PYCR2 | 0.958 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| NSUN5 | PYCR1 | 0.934 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| NSUN5 | PYCR3 | 0.054 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes