hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05636.1
Complex Portal: CPX-21633
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PATL1 | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | 5 | UniProt NCBI |
| LSM7 | U6 snRNA-associated Sm-like protein LSm7 | 5 | UniProt NCBI |
| LSM1 | U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm) | 5 | UniProt NCBI |
| TMCO6 | Transmembrane and coiled-coil domain-containing protein 6 | 3 | UniProt NCBI |
| LSM6 | U6 snRNA-associated Sm-like protein LSm6 | 5 | UniProt NCBI |
| LSM5 | U6 snRNA-associated Sm-like protein LSm5 | 5 | UniProt NCBI |
| ZNF511 | Zinc finger protein 511 | 5 | UniProt NCBI |
| LSM4 | U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-430039 | 2.20287996704e-15 | 0.75 | LSM6 PATL1 LSM5 LSM7 LSM1 LSM4 | mRNA decay by 5' to 3' exoribonuclease |
| CORUM:561 | 1.93166787145e-14 | 0.625 | LSM7 LSM5 LSM4 LSM1 LSM6 | LSm1-7 complex |
| REAC:R-HSA-429914 | 1.26995447193e-11 | 0.75 | LSM6 PATL1 LSM5 LSM7 LSM1 LSM4 | Deadenylation-dependent mRNA decay |
| KEGG:03018 | 1.731442743e-11 | 0.75 | LSM6 PATL1 LSM5 LSM7 LSM1 LSM4 | RNA degradation |
| CORUM:562 | 1.17561307601e-10 | 0.5 | LSM7 LSM4 LSM6 LSM5 | LSm2-8 complex |
| GO:0120115 | 6.44235965654e-08 | 0.5 | LSM7 LSM4 LSM6 LSM5 | Lsm2-8 complex |
| GO:0005688 | 1.28818969855e-07 | 0.5 | LSM7 LSM4 LSM6 LSM5 | U6 snRNP |
| GO:0120114 | 1.63146572742e-05 | 0.625 | LSM7 LSM5 LSM4 LSM1 LSM6 | Sm-like protein family complex |
| KEGG:03040 | 1.72100778664e-05 | 0.5 | LSM7 LSM4 LSM6 LSM5 | Spliceosome |
| GO:1990726 | 5.37995977657e-05 | 0.375 | LSM7 LSM1 LSM5 | Lsm1-7-Pat1 complex |
| REAC:R-HSA-8953854 | 5.65270307937e-05 | 0.75 | LSM6 PATL1 LSM5 LSM7 LSM1 LSM4 | Metabolism of RNA |
| GO:0097526 | 8.48593735273e-05 | 0.5 | LSM7 LSM4 LSM6 LSM5 | spliceosomal tri-snRNP complex |
| GO:0046540 | 8.48593735273e-05 | 0.5 | LSM7 LSM4 LSM6 LSM5 | U4/U6 x U5 tri-snRNP complex |
| GO:0071005 | 0.000419928845551 | 0.5 | LSM7 LSM4 LSM6 LSM5 | U2-type precatalytic spliceosome |
| GO:0071011 | 0.000493423074079 | 0.5 | LSM7 LSM4 LSM6 LSM5 | precatalytic spliceosome |
| REAC:R-HSA-72163 | 0.000495335177477 | 0.5 | LSM7 LSM4 LSM6 LSM5 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.000567724058779 | 0.5 | LSM7 LSM4 LSM6 LSM5 | mRNA Splicing |
| GO:0097525 | 0.00115498793492 | 0.5 | LSM7 LSM4 LSM6 LSM5 | spliceosomal snRNP complex |
| REAC:R-HSA-72203 | 0.00169661698674 | 0.5 | LSM7 LSM4 LSM6 LSM5 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0030532 | 0.00197464201845 | 0.5 | LSM7 LSM4 LSM6 LSM5 | small nuclear ribonucleoprotein complex |
| GO:0000932 | 0.00220411413747 | 0.5 | PATL1 LSM4 LSM1 LSM6 | P-body |
| GO:0016071 | 0.00379022160939 | 0.75 | LSM6 PATL1 LSM5 LSM7 LSM1 LSM4 | mRNA metabolic process |
| CORUM:351 | 0.00397822087206 | 0.375 | LSM7 LSM6 LSM4 | Spliceosome |
| GO:0005684 | 0.00441407178313 | 0.5 | LSM7 LSM4 LSM6 LSM5 | U2-type spliceosomal complex |
| GO:0000375 | 0.00554969026619 | 0.625 | LSM7 LSM5 LSM4 LSM1 LSM6 | RNA splicing, via transesterification reactions |
| GO:0006397 | 0.0162523964013 | 0.625 | LSM7 LSM5 LSM4 LSM1 LSM6 | mRNA processing |
| GO:0008380 | 0.0252266107187 | 0.625 | LSM7 LSM5 LSM4 LSM1 LSM6 | RNA splicing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LSM1 | LSM6 | 1.0 | 0.334 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| LSM6 | LSM4 | 1.0 | 0.988 | youn () bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM | |
| LSM7 | LSM6 | 1.0 | 0.95 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction boldt_WMM | |
| LSM5 | LSM4 | 1.0 | 0.922 |
mutually_exclusive (O15116)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| LSM6 | LSM5 | 1.0 | 0.868 |
mutually_exclusive (O15116)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| LSM1 | LSM5 | 1.0 | 0.462 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| LSM7 | LSM5 | 1.0 | 0.896 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | |
| PATL1 | LSM1 | 1.0 | 0.172 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| LSM7 | LSM4 | 1.0 | 0.968 |
structurally_consistent (P83876)
|
youn () bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| LSM7 | LSM1 | 1.0 | 0.486 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| LSM1 | LSM4 | 0.999 | 0.254 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| PATL1 | LSM6 | 0.999 | 0.108 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| TMCO6 | ZNF511 | 0.999 | 0.208 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PATL1 | LSM4 | 0.999 | 0.098 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| LSM6 | ZNF511 | 0.999 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PATL1 | LSM7 | 0.999 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PATL1 | LSM5 | 0.998 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| LSM5 | ZNF511 | 0.998 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LSM7 | ZNF511 | 0.997 | 0.168 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMCO6 | LSM5 | 0.996 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LSM7 | TMCO6 | 0.995 | 0.138 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZNF511 | LSM4 | 0.989 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TMCO6 | LSM4 | 0.982 | 0.092 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| TMCO6 | LSM6 | 0.975 | 0.072 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PATL1 | TMCO6 | 0.898 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| PATL1 | ZNF511 | 0.871 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only | |
| LSM1 | ZNF511 | 0.861 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| LSM1 | TMCO6 | 0.831 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes