hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05672.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRP1B | Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) | 5 | UniProt NCBI |
| VLDLR | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | 5 | UniProt NCBI |
| LRPAP1 | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | 5 | UniProt NCBI |
| LRP2 | Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) | 5 | UniProt NCBI |
| LRP8 | Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) | 5 | UniProt NCBI |
| LRP1 | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005041 | 1.08105219171e-10 | 0.833333333333 | LRP2 LRP1 LRP1B LRP8 VLDLR | low-density lipoprotein particle receptor activity |
| GO:0030228 | 2.35839012012e-10 | 0.833333333333 | LRP2 LRP1 LRP1B LRP8 VLDLR | lipoprotein particle receptor activity |
| GO:0038024 | 5.85425247341e-08 | 0.833333333333 | LRP2 LRP1 LRP1B LRP8 VLDLR | cargo receptor activity |
| KEGG:04979 | 2.10901914164e-05 | 0.5 | LRP2 LRPAP1 LRP1 | Cholesterol metabolism |
| GO:0006897 | 4.46753689701e-05 | 1.0 | LRPAP1 LRP2 VLDLR LRP8 LRP1 LRP1B | endocytosis |
| REAC:R-HSA-975634 | 6.94313281717e-05 | 0.5 | LRP2 LRP1 LRP8 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 8.6685788479e-05 | 0.5 | LRP2 LRP1 LRP8 | Metabolism of fat-soluble vitamins |
| GO:0006898 | 0.00010460322276 | 0.833333333333 | LRP2 LRPAP1 LRP1 LRP1B VLDLR | receptor-mediated endocytosis |
| GO:0098657 | 0.000226737460828 | 1.0 | LRPAP1 LRP2 VLDLR LRP8 LRP1 LRP1B | import into cell |
| GO:0034185 | 0.00042234232358 | 0.5 | LRP8 VLDLR LRP1 | apolipoprotein binding |
| REAC:R-HSA-2187338 | 0.000531494169007 | 0.5 | LRP2 LRP1 LRP8 | Visual phototransduction |
| WP:WP5110 | 0.00055327344683 | 0.333333333333 | VLDLR LRP1 | Familial hyperlipidemia type 3 |
| GO:0043235 | 0.000749076431754 | 0.833333333333 | LRP2 LRP1 LRP1B LRP8 VLDLR | receptor complex |
| GO:0045056 | 0.000873077093697 | 0.5 | LRP2 LRPAP1 LRP1 | transcytosis |
| REAC:R-HSA-196854 | 0.00436661776769 | 0.5 | LRP2 LRP1 LRP8 | Metabolism of vitamins and cofactors |
| GO:0038025 | 0.00702301080125 | 0.333333333333 | LRP8 VLDLR | reelin receptor activity |
| GO:0016192 | 0.00887756788753 | 1.0 | LRPAP1 LRP2 VLDLR LRP8 LRP1 LRP1B | vesicle-mediated transport |
| GO:0097242 | 0.00949259421943 | 0.5 | LRP2 LRPAP1 LRP1 | amyloid-beta clearance |
| REAC:R-HSA-9709957 | 0.0101216651073 | 0.5 | LRP2 LRP1 LRP8 | Sensory Perception |
| WP:WP5304 | 0.0182415379951 | 0.333333333333 | LRPAP1 LRP1 | Cholesterol metabolism |
| GO:1905167 | 0.0210651876021 | 0.333333333333 | LRP2 LRP1 | positive regulation of lysosomal protein catabolic process |
| GO:0030229 | 0.0210651876021 | 0.333333333333 | LRP8 VLDLR | very-low-density lipoprotein particle receptor activity |
| GO:0038026 | 0.042122686785 | 0.333333333333 | LRP8 VLDLR | reelin-mediated signaling pathway |
| CORUM:7535 | 0.0499436884912 | 0.166666666667 | LRP1 | CD44-LRP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LRP1B | LRPAP1 | 0.995 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRP2 | LRPAP1 | 0.99 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRP8 | LRPAP1 | 0.979 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VLDLR | LRPAP1 | 0.966 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRPAP1 | LRP1 | 0.96 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRP1B | LRP1 | 0.778 | 0.082 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| LRP1B | LRP2 | 0.673 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP2 | LRP1 | 0.575 | 0.254 | bioplex_WMM bioplex3_WMM WMM_only |
| VLDLR | LRP2 | 0.497 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only |
| VLDLR | LRP1B | 0.194 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | LRP1B | 0.19 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | VLDLR | 0.172 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
| VLDLR | LRP1 | 0.117 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | LRP1 | 0.111 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | LRP2 | 0.066 | 0.086 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes