hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05673.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FARSA | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | 5 | UniProt NCBI |
| PRKDC | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460) | 5 | UniProt NCBI |
| CAND1 | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | 5 | UniProt NCBI |
| NUP188 | Nucleoporin NUP188 (hNup188) | 5 | UniProt NCBI |
| NUP205 | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | 5 | UniProt NCBI |
| NUP93 | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | 5 | UniProt NCBI |
| GCN1 | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | 5 | UniProt NCBI |
| MICOS13 | MICOS complex subunit MIC13 (Protein P117) | 5 | UniProt NCBI |
| TELO2 | Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) | 5 | UniProt NCBI |
| DPM1 | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1) | 5 | UniProt NCBI |
| BSG | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5619102 | 4.02196065274e-05 | 0.363636363636 | NUP188 BSG NUP205 NUP93 | SLC transporter disorders |
| REAC:R-HSA-9615933 | 0.000164893810838 | 0.272727272727 | NUP188 NUP205 NUP93 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-5619107 | 0.000266454974375 | 0.272727272727 | NUP188 NUP205 NUP93 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-170822 | 0.000266454974375 | 0.272727272727 | NUP188 NUP205 NUP93 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168274 | 0.000297077659185 | 0.272727272727 | NUP188 NUP205 NUP93 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 0.000297077659185 | 0.272727272727 | NUP188 NUP205 NUP93 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168333 | 0.000297077659185 | 0.272727272727 | NUP188 NUP205 NUP93 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-159227 | 0.000365152395088 | 0.272727272727 | NUP188 NUP205 NUP93 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180910 | 0.000365152395088 | 0.272727272727 | NUP188 NUP205 NUP93 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-180746 | 0.000365152395088 | 0.272727272727 | NUP188 NUP205 NUP93 | Nuclear import of Rev protein |
| REAC:R-HSA-4085377 | 0.000402761203913 | 0.272727272727 | NUP188 NUP205 NUP93 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-165054 | 0.000402761203913 | 0.272727272727 | NUP188 NUP205 NUP93 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-159230 | 0.000402761203913 | 0.272727272727 | NUP188 NUP205 NUP93 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-3301854 | 0.000442855259632 | 0.272727272727 | NUP188 NUP205 NUP93 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-177243 | 0.000485512613032 | 0.272727272727 | NUP188 NUP205 NUP93 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 0.000485512613032 | 0.272727272727 | NUP188 NUP205 NUP93 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 0.000530811183897 | 0.272727272727 | NUP188 NUP205 NUP93 | SUMOylation of ubiquitinylation proteins |
| HP:0012116 | 0.00053759504131 | 0.363636363636 | MICOS13 NUP93 FARSA NUP205 | Abnormal circulating albumin concentration |
| HP:0003073 | 0.00053759504131 | 0.363636363636 | MICOS13 NUP93 FARSA NUP205 | Hypoalbuminemia |
| REAC:R-HSA-168276 | 0.000629643002906 | 0.272727272727 | NUP188 NUP205 NUP93 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-5619115 | 0.000673408338632 | 0.363636363636 | NUP188 BSG NUP205 NUP93 | Disorders of transmembrane transporters |
| REAC:R-HSA-159231 | 0.000683331436742 | 0.272727272727 | NUP188 NUP205 NUP93 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.000739971459679 | 0.272727272727 | NUP188 NUP205 NUP93 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.000799640338384 | 0.272727272727 | NUP188 NUP205 NUP93 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 0.000928373078657 | 0.272727272727 | NUP188 NUP205 NUP93 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 0.000997590822835 | 0.272727272727 | NUP188 NUP205 NUP93 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 0.00130859353099 | 0.272727272727 | NUP188 NUP205 NUP93 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 0.00167787062795 | 0.272727272727 | NUP188 NUP205 NUP93 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.00167787062795 | 0.272727272727 | NUP188 NUP205 NUP93 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 0.00211028007235 | 0.272727272727 | NUP188 NUP205 NUP93 | tRNA processing in the nucleus |
| KEGG:03013 | 0.00258780243418 | 0.272727272727 | NUP188 NUP205 NUP93 | Nucleocytoplasmic transport |
| WP:WP3998 | 0.00294376640307 | 0.272727272727 | NUP188 NUP205 NUP93 | Prader Willi and Angelman syndrome |
| REAC:R-HSA-3371453 | 0.0034990910184 | 0.272727272727 | NUP188 NUP205 NUP93 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.0034990910184 | 0.272727272727 | NUP188 NUP205 NUP93 | Glycolysis |
| REAC:R-HSA-4551638 | 0.00366420663692 | 0.272727272727 | NUP188 NUP205 NUP93 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-1169408 | 0.00366420663692 | 0.272727272727 | NUP188 NUP205 NUP93 | ISG15 antiviral mechanism |
| REAC:R-HSA-2995410 | 0.00383438848982 | 0.272727272727 | NUP188 NUP205 NUP93 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-159236 | 0.00437606749304 | 0.272727272727 | NUP188 NUP205 NUP93 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 0.00456724968844 | 0.272727272727 | NUP188 NUP205 NUP93 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.00476386518789 | 0.272727272727 | NUP188 NUP205 NUP93 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-70326 | 0.00629842523359 | 0.272727272727 | NUP188 NUP205 NUP93 | Glucose metabolism |
| REAC:R-HSA-72202 | 0.00629842523359 | 0.272727272727 | NUP188 NUP205 NUP93 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-3371556 | 0.00784735633052 | 0.272727272727 | NUP188 NUP205 NUP93 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 0.00962827118562 | 0.272727272727 | NUP188 NUP205 NUP93 | Transcriptional regulation by small RNAs |
| CORUM:1183 | 0.0101629288365 | 0.181818181818 | PRKDC GCN1 | CDC5L complex |
| REAC:R-HSA-72306 | 0.0123901602043 | 0.272727272727 | NUP188 NUP205 NUP93 | tRNA processing |
| REAC:R-HSA-9610379 | 0.0123901602043 | 0.272727272727 | NUP188 NUP205 NUP93 | HCMV Late Events |
| REAC:R-HSA-392499 | 0.0164010508062 | 0.636363636364 | DPM1 NUP188 NUP205 CAND1 FARSA PRKDC NUP93 | Metabolism of proteins |
| REAC:R-HSA-9705671 | 0.0179082192703 | 0.272727272727 | NUP188 NUP205 NUP93 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-211000 | 0.0209204552699 | 0.272727272727 | NUP188 NUP205 NUP93 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.0219936664771 | 0.272727272727 | NUP188 NUP205 NUP93 | HCMV Early Events |
| REAC:R-HSA-68875 | 0.0231023412725 | 0.272727272727 | NUP188 NUP205 NUP93 | Mitotic Prophase |
| GO:0017056 | 0.0242342063386 | 0.272727272727 | NUP188 NUP205 NUP93 | structural constituent of nuclear pore |
| HP:0010876 | 0.0244678808231 | 0.454545454545 | MICOS13 DPM1 NUP93 FARSA NUP205 | Abnormal circulating protein concentration |
| REAC:R-HSA-162909 | 0.0248330185761 | 0.272727272727 | NUP188 NUP205 NUP93 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.027902357559 | 0.272727272727 | NUP188 NUP205 NUP93 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 0.0285445528455 | 0.272727272727 | NUP188 NUP205 NUP93 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-597592 | 0.0292756297165 | 0.545454545455 | DPM1 PRKDC NUP205 CAND1 NUP188 NUP93 | Post-translational protein modification |
| REAC:R-HSA-162587 | 0.0362564488154 | 0.272727272727 | NUP188 NUP205 NUP93 | HIV Life Cycle |
| REAC:R-HSA-9609646 | 0.0362564488154 | 0.272727272727 | NUP188 NUP205 NUP93 | HCMV Infection |
| REAC:R-HSA-168255 | 0.0409833420858 | 0.272727272727 | NUP188 NUP205 NUP93 | Influenza Infection |
| REAC:R-HSA-3108232 | 0.0497239830603 | 0.272727272727 | NUP188 NUP205 NUP93 | SUMO E3 ligases SUMOylate target proteins |
| HP:0012588 | 0.0498048563326 | 0.181818181818 | NUP205 NUP93 | Steroid-resistant nephrotic syndrome |
| CORUM:322 | 0.049976851631 | 0.0909090909091 | PRKDC | DNA-PK-Ku complex |
| CORUM:355 | 0.049976851631 | 0.0909090909091 | PRKDC | DNA-PK-Ku complex |
| CORUM:356 | 0.049976851631 | 0.0909090909091 | PRKDC | DNA-PK-Ku complex |
| CORUM:357 | 0.049976851631 | 0.0909090909091 | PRKDC | DNA-PK-Ku complex |
| CORUM:5182 | 0.049976851631 | 0.0909090909091 | PRKDC | DNA-PK-Ku complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| NUP188 | NUP93 | 0.999 | 0.784 |
| NUP205 | NUP93 | 0.999 | 0.944 |
| TELO2 | BSG | 0.997 | 0.028 |
| NUP188 | NUP205 | 0.995 | 0.914 |
| FARSA | DPM1 | 0.994 | 0.064 |
| CAND1 | BSG | 0.993 | 0.17 |
| NUP205 | BSG | 0.992 | 0.122 |
| CAND1 | GCN1 | 0.992 | 0.568 |
| FARSA | NUP93 | 0.991 | 0.364 |
| FARSA | MICOS13 | 0.99 | 0.052 |
| NUP93 | GCN1 | 0.989 | 0.3 |
| MICOS13 | DPM1 | 0.986 | 0.078 |
| NUP93 | MICOS13 | 0.985 | 0.082 |
| PRKDC | DPM1 | 0.984 | 0.26 |
| FARSA | GCN1 | 0.984 | 0.224 |
| NUP205 | MICOS13 | 0.984 | 0.174 |
| PRKDC | NUP93 | 0.983 | 0.552 |
| PRKDC | TELO2 | 0.982 | 0.11 |
| CAND1 | NUP93 | 0.982 | 0.308 |
| GCN1 | BSG | 0.982 | 0.2 |
| NUP93 | DPM1 | 0.981 | 0.144 |
| PRKDC | GCN1 | 0.979 | 0.476 |
| CAND1 | DPM1 | 0.979 | 0.166 |
| PRKDC | CAND1 | 0.978 | 0.594 |
| NUP205 | GCN1 | 0.978 | 0.358 |
| NUP205 | DPM1 | 0.977 | 0.192352941176 |
| MICOS13 | TELO2 | 0.976 | 0.016 |
| PRKDC | BSG | 0.975 | 0.164 |
| GCN1 | DPM1 | 0.974 | 0.148 |
| GCN1 | MICOS13 | 0.974 | 0.108 |
| NUP205 | TELO2 | 0.973 | 0.154 |
| PRKDC | MICOS13 | 0.972 | 0.078 |
| PRKDC | NUP205 | 0.972 | 0.454 |
| NUP93 | TELO2 | 0.971 | 0.158 |
| FARSA | NUP205 | 0.969 | 0.094 |
| NUP188 | BSG | 0.958 | 0.128 |
| NUP188 | GCN1 | 0.956 | 0.39 |
| FARSA | CAND1 | 0.952 | 0.254 |
| FARSA | TELO2 | 0.944 | 0.106 |
| CAND1 | TELO2 | 0.942 | 0.202 |
| CAND1 | MICOS13 | 0.939 | 0.1 |
| CAND1 | NUP205 | 0.934 | 0.226 |
| NUP188 | MICOS13 | 0.927 | 0.048 |
| GCN1 | TELO2 | 0.92 | 0.136 |
| NUP93 | BSG | 0.91 | 0.126 |
| DPM1 | BSG | 0.907 | 0.054 |
| FARSA | PRKDC | 0.869 | 0.324 |
| TELO2 | DPM1 | 0.817 | 0.07 |
| PRKDC | NUP188 | 0.799 | 0.392 |
| NUP188 | DPM1 | 0.751 | 0.188 |
| FARSA | BSG | 0.683 | 0.058 |
| NUP188 | TELO2 | 0.602 | 0.132 |
| CAND1 | NUP188 | 0.544 | 0.254 |
| FARSA | NUP188 | 0.512 | 0.17 |
| MICOS13 | BSG | 0.253 | 0.044 |
Related Complexes