hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05674.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
ANXA2	Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)	5	UniProt NCBI
FLNB	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	5	UniProt NCBI
GNAS	Protein ALEX (Alternative gene product encoded by XL-exon)	5	UniProt NCBI
PALM	Paralemmin-1 (Paralemmin)	5	UniProt NCBI
GNAI1	Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)	5	UniProt NCBI
CCNY	Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X)	5	UniProt NCBI
AHNAK	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	5	UniProt NCBI
GNA11	Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)	5	UniProt NCBI
GNG12	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	5	UniProt NCBI
RAP1B	Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)	5	UniProt NCBI
CD59	CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)	5	UniProt NCBI
FLOT1	Flotillin-1	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7088	2.73623797451e-05	0.222222222222	GNAI1 GNG12	GNAI1-GNB3-GNG12 complex
CORUM:7090	8.20609246787e-05	0.222222222222	GNAI1 GNG12	GNAI1-GNB5-GNG12 complex
CORUM:7089	8.20609246787e-05	0.222222222222	GNAI1 GNG12	GNAI1-GNB4-GNG12 complex
CORUM:7087	8.20609246787e-05	0.222222222222	GNAI1 GNG12	GNAI1-GNB2-GNG12 complex
HPA:0291163	0.00235556877982	0.444444444444	CCNY FLOT1 ANXA2 FLNB	liver; cholangiocytes[High]
KEGG:04062	0.00342866970736	0.333333333333	GNAI1 RAP1B GNG12	Chemokine signaling pathway
WP:WP3929	0.00409127570846	0.333333333333	GNAI1 RAP1B GNG12	Chemokine signaling pathway
KEGG:05132	0.0140921621497	0.333333333333	AHNAK ANXA2 FLNB	Salmonella infection
REAC:R-HSA-392170	0.0150906736209	0.222222222222	GNAI1 GNG12	ADP signalling through P2Y purinoceptor 12
WP:WP2636	0.0151103173393	0.222222222222	GNAI1 RAP1B	Common pathways underlying drug addiction
KEGG:04010	0.0179039523177	0.333333333333	GNG12 FLNB RAP1B	MAPK signaling pathway
REAC:R-HSA-400042	0.0183353632609	0.222222222222	GNAI1 GNG12	Adrenaline,noradrenaline inhibits insulin secretion
WP:WP382	0.0184784380745	0.333333333333	GNG12 FLNB RAP1B	MAPK signaling pathway
GO:0005765	0.0313523212218	0.555555555556	FLOT1 GNAI1 RAP1B ANXA2 AHNAK	lysosomal membrane
GO:0098852	0.0313523212218	0.555555555556	FLOT1 GNAI1 RAP1B ANXA2 AHNAK	lytic vacuole membrane
REAC:R-HSA-392518	0.0344394959621	0.222222222222	GNAI1 GNG12	Signal amplification
KEGG:04727	0.0369068821541	0.222222222222	GNAI1 GNG12	GABAergic synapse
KEGG:05032	0.0380131203218	0.222222222222	GNAI1 GNG12	Morphine addiction
REAC:R-HSA-991365	0.0417623735111	0.222222222222	GNAI1 GNG12	Activation of GABAB receptors
REAC:R-HSA-977444	0.0417623735111	0.222222222222	GNAI1 GNG12	GABA B receptor activation
REAC:R-HSA-109582	0.0425606863338	0.444444444444	GNAI1 RAP1B ANXA2 GNG12	Hemostasis
KEGG:04713	0.0437835593024	0.222222222222	GNAI1 GNG12	Circadian entrainment
WP:WP2032	0.0449082842831	0.222222222222	GNAI1 RAP1B	Thyroid stimulating hormone TSH signaling pathway
GO:0005774	0.0458422366288	0.555555555556	FLOT1 GNAI1 RAP1B ANXA2 AHNAK	vacuolar membrane
REAC:R-HSA-9660821	0.0470317013402	0.222222222222	GNAI1 GNG12	ADORA2B mediated anti-inflammatory cytokines production
REAC:R-HSA-418597	0.0470317013402	0.222222222222	GNAI1 GNG12	G alpha (z) signalling events
REAC:R-HSA-9634597	0.0497823629923	0.222222222222	GNAI1 GNG12	GPER1 signaling
CORUM:7094	0.0499842271994	0.111111111111	GNAI1	GNAI1-GNB3-GNG13 complex
CORUM:7206	0.0499842271994	0.111111111111	GNG12	GNAS-L-GNB3-GNG12 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD
GNAS	GNG12	0.998
FLOT1	PALM	0.997	0.094
FLOT1	GNG12	0.997	0.074
CCNY	GNA11	0.997	0.272
GNAI1	GNG12	0.997	0.084
FLOT1	GNA11	0.995	0.08
GNAI1	PALM	0.993	0.17
GNAS	GNAI1	0.993
GNAI1	AHNAK	0.993	0.052
CCNY	PALM	0.992	0.052
GNG12	PALM	0.992	0.07
FLOT1	FLNB	0.992	0.246
PALM	RAP1B	0.991	0.066
GNAS	CCNY	0.991
GNG12	CD59	0.99	0.324
GNAI1	GNA11	0.99	0.206
FLOT1	GNAI1	0.99	0.22
GNAS	PALM	0.989
FLOT1	AHNAK	0.989	0.284
FLNB	AHNAK	0.987	0.666
FLOT1	CD59	0.987	0.084
FLOT1	RAP1B	0.984	0.118
RAP1B	CD59	0.981	0.172
GNAI1	CD59	0.98	0.21
PALM	AHNAK	0.979	0.18680952381
GNAS	FLOT1	0.979
GNAS	GNA11	0.976
CCNY	AHNAK	0.975	0.068
GNA11	CD59	0.974	0.138
FLNB	PALM	0.973	0.158
FLOT1	ANXA2	0.973	0.19
FLOT1	CCNY	0.967	0.148
GNA11	AHNAK	0.966	0.066
AHNAK	CD59	0.965	0.19
FLNB	CD59	0.964	0.074
PALM	CD59	0.96	0.06
GNAS	RAP1B	0.957
GNAS	ANXA2	0.953
GNA11	PALM	0.951	0.046
GNG12	AHNAK	0.95	0.288
ANXA2	AHNAK	0.944	0.572
FLNB	RAP1B	0.941	0.15
GNAI1	FLNB	0.933	0.118
GNA11	GNG12	0.922	0.144
PALM	ANXA2	0.892	0.288
FLNB	GNA11	0.891	0.08
GNAI1	ANXA2	0.877	0.192
AHNAK	RAP1B	0.857	0.16
ANXA2	CD59	0.839	0.134
GNAS	CD59	0.835
GNA11	RAP1B	0.831	0.058
CCNY	CD59	0.809	0.096
CCNY	RAP1B	0.795	0.118
GNAS	AHNAK	0.791
GNAS	FLNB	0.775
ANXA2	RAP1B	0.703	0.104
FLNB	CCNY	0.681	0.09
FLNB	ANXA2	0.625	0.588
GNG12	ANXA2	0.565	0.216
FLNB	GNG12	0.454	0.392
CCNY	GNG12	0.405	0.04
GNAI1	CCNY	0.213	0.282
GNAI1	RAP1B	0.141	0.226
GNG12	RAP1B	0.042	0.126
GNA11	ANXA2	0.035	0.068
CCNY	ANXA2	0.027	0.072

Related Complexes

Genename	Complexes
ANXA2	huMAP3_05674.1 huMAP3_07836.1 huMAP3_09165.1 huMAP3_13705.1 huMAP3_15218.1
FLNB	huMAP3_00941.1 huMAP3_05674.1 huMAP3_08043.1 huMAP3_09631.1
GNAS	huMAP3_00249.1 huMAP3_05674.1 huMAP3_07836.1 huMAP3_09165.1 huMAP3_11173.1 huMAP3_12729.1
PALM	huMAP3_04672.1 huMAP3_05674.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_14897.1
GNAI1	huMAP3_00466.1 huMAP3_05502.1 huMAP3_05674.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1
CCNY	huMAP3_01080.1 huMAP3_04672.1 huMAP3_05546.1 huMAP3_05674.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09940.1 huMAP3_12303.1 huMAP3_12658.1
AHNAK	huMAP3_05674.1 huMAP3_08718.1 huMAP3_09165.1
GNA11	huMAP3_02332.1 huMAP3_05674.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_10795.1 huMAP3_11173.1 huMAP3_13105.1
GNG12	huMAP3_03550.1 huMAP3_05674.1 huMAP3_07033.1 huMAP3_08591.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1
RAP1B	huMAP3_05674.1 huMAP3_06217.1 huMAP3_07836.1 huMAP3_08271.1 huMAP3_09165.1 huMAP3_11118.1
CD59	huMAP3_05674.1 huMAP3_09165.1 huMAP3_13532.1
FLOT1	huMAP3_00249.1 huMAP3_05674.1 huMAP3_08718.1 huMAP3_09165.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05674.1