hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05683.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRAK1 | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | 5 | UniProt NCBI |
| TRAK2 | Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein) | 5 | UniProt NCBI |
| RHOT1 | Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013425 | 4.66602141148e-09 | 1.0 | RHOT1 TRAK1 TRAK2 | RHOT1 GTPase cycle |
| REAC:R-HSA-9715370 | 2.61297199043e-08 | 1.0 | RHOT1 TRAK1 TRAK2 | Miro GTPase Cycle |
| CORUM:177 | 1.02521027753e-05 | 0.666666666667 | TRAK1 TRAK2 | OGT-TRAK1-TRAK2 complex |
| GO:0034643 | 7.84339535184e-05 | 1.0 | RHOT1 TRAK1 TRAK2 | establishment of mitochondrion localization, microtubule-mediated |
| GO:0047497 | 7.84339535184e-05 | 1.0 | RHOT1 TRAK1 TRAK2 | mitochondrion transport along microtubule |
| GO:0051654 | 0.000127839654632 | 1.0 | RHOT1 TRAK1 TRAK2 | establishment of mitochondrion localization |
| REAC:R-HSA-9013419 | 0.000143154936711 | 0.666666666667 | TRAK1 TRAK2 | RHOT2 GTPase cycle |
| GO:0051646 | 0.000524430944113 | 1.0 | RHOT1 TRAK1 TRAK2 | mitochondrion localization |
| GO:0098957 | 0.00421361424067 | 0.666666666667 | TRAK1 TRAK2 | anterograde axonal transport of mitochondrion |
| GO:0072384 | 0.00549374094772 | 1.0 | RHOT1 TRAK1 TRAK2 | organelle transport along microtubule |
| REAC:R-HSA-9716542 | 0.02067413488 | 1.0 | RHOT1 TRAK1 TRAK2 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0010970 | 0.039413061643 | 1.0 | RHOT1 TRAK1 TRAK2 | transport along microtubule |
| CORUM:5836 | 0.0499402709677 | 0.333333333333 | TRAK1 | MIRO2-Milton complex |
| CORUM:7345 | 0.0499402709677 | 0.333333333333 | TRAK1 | DISC1-TRAK1 complex |
| CORUM:7346 | 0.0499402709677 | 0.333333333333 | RHOT1 | DISC1-RHOT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRAK1 | TRAK2 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RHOT1 | TRAK2 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRAK1 | RHOT1 | 0.967 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes