hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05687.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| YES1 | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | 5 | UniProt NCBI |
| LYN | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | 5 | UniProt NCBI |
| FYN | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | 5 | UniProt NCBI |
| DSG2 | Desmoglein-2 (Cadherin family member 5) (HDGC) | 5 | UniProt NCBI |
| GPRC5A | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) | 5 | UniProt NCBI |
| S100A10 | Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) | 5 | UniProt NCBI |
| CSNK1G3 | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2564 | 7.02338504734e-09 | 0.428571428571 | YES1 FYN LYN | p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated |
| REAC:R-HSA-210990 | 1.09397266507e-06 | 0.428571428571 | YES1 FYN LYN | PECAM1 interactions |
| REAC:R-HSA-2029481 | 1.09397266507e-06 | 0.428571428571 | YES1 FYN LYN | FCGR activation |
| REAC:R-HSA-1433559 | 3.72165755864e-06 | 0.428571428571 | YES1 FYN LYN | Regulation of KIT signaling |
| REAC:R-HSA-9669938 | 8.84142817265e-06 | 0.428571428571 | YES1 FYN LYN | Signaling by KIT in disease |
| REAC:R-HSA-9670439 | 8.84142817265e-06 | 0.428571428571 | YES1 FYN LYN | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
| REAC:R-HSA-389513 | 1.06075342669e-05 | 0.428571428571 | YES1 FYN LYN | CTLA4 inhibitory signaling |
| REAC:R-HSA-912631 | 1.25938591632e-05 | 0.428571428571 | YES1 FYN LYN | Regulation of signaling by CBL |
| REAC:R-HSA-3928663 | 3.374300022e-05 | 0.428571428571 | YES1 FYN LYN | EPHA-mediated growth cone collapse |
| WP:WP2203 | 3.62383476827e-05 | 0.428571428571 | YES1 FYN LYN | Thymic stromal lymphopoietin TSLP signaling pathway |
| REAC:R-HSA-9680350 | 4.24987071653e-05 | 0.428571428571 | YES1 FYN LYN | Signaling by CSF1 (M-CSF) in myeloid cells |
| REAC:R-HSA-389356 | 4.73926619295e-05 | 0.428571428571 | YES1 FYN LYN | CD28 co-stimulation |
| REAC:R-HSA-9664323 | 5.26476903505e-05 | 0.428571428571 | YES1 FYN LYN | FCGR3A-mediated IL10 synthesis |
| CORUM:2565 | 6.1565588648e-05 | 0.285714285714 | LYN FYN | CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line) |
| CORUM:2563 | 6.1565588648e-05 | 0.285714285714 | LYN FYN | FGFR2-c-Cbl-Lyn-Fyn complex |
| REAC:R-HSA-1433557 | 9.24731829377e-05 | 0.428571428571 | YES1 FYN LYN | Signaling by SCF-KIT |
| REAC:R-HSA-3928662 | 0.000109213310364 | 0.428571428571 | YES1 FYN LYN | EPHB-mediated forward signaling |
| REAC:R-HSA-512988 | 0.000118290093408 | 0.428571428571 | YES1 FYN LYN | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| REAC:R-HSA-3928665 | 0.000171246735353 | 0.428571428571 | YES1 FYN LYN | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-9664417 | 0.00030234111687 | 0.428571428571 | YES1 FYN LYN | Leishmania phagocytosis |
| REAC:R-HSA-9664422 | 0.00030234111687 | 0.428571428571 | YES1 FYN LYN | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664407 | 0.00030234111687 | 0.428571428571 | YES1 FYN LYN | Parasite infection |
| REAC:R-HSA-388841 | 0.000377325314633 | 0.428571428571 | YES1 FYN LYN | Costimulation by the CD28 family |
| REAC:R-HSA-9664433 | 0.000487210059522 | 0.428571428571 | YES1 FYN LYN | Leishmania parasite growth and survival |
| REAC:R-HSA-9662851 | 0.000487210059522 | 0.428571428571 | YES1 FYN LYN | Anti-inflammatory response favouring Leishmania parasite infection |
| REAC:R-HSA-2029480 | 0.000976813602208 | 0.428571428571 | YES1 FYN LYN | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-2682334 | 0.00113617130448 | 0.428571428571 | YES1 FYN LYN | EPH-Ephrin signaling |
| REAC:R-HSA-2730905 | 0.00171179400053 | 0.285714285714 | LYN FYN | Role of LAT2/NTAL/LAB on calcium mobilization |
| REAC:R-HSA-75892 | 0.00171179400053 | 0.285714285714 | LYN FYN | Platelet Adhesion to exposed collagen |
| GO:0002862 | 0.00187892941497 | 0.428571428571 | YES1 FYN LYN | negative regulation of inflammatory response to antigenic stimulus |
| REAC:R-HSA-202733 | 0.00219374690011 | 0.428571428571 | YES1 FYN LYN | Cell surface interactions at the vascular wall |
| GO:0038096 | 0.00382182132582 | 0.428571428571 | YES1 FYN LYN | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0002433 | 0.00382182132582 | 0.428571428571 | YES1 FYN LYN | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| WP:WP4357 | 0.00409583359214 | 0.285714285714 | YES1 FYN | NRF2 ARE regulation |
| REAC:R-HSA-5621480 | 0.00455853850403 | 0.285714285714 | LYN FYN | Dectin-2 family |
| GO:0002861 | 0.00516068999797 | 0.428571428571 | YES1 FYN LYN | regulation of inflammatory response to antigenic stimulus |
| REAC:R-HSA-9658195 | 0.00520230847661 | 0.428571428571 | YES1 FYN LYN | Leishmania infection |
| REAC:R-HSA-9824443 | 0.00520230847661 | 0.428571428571 | YES1 FYN LYN | Parasitic Infection Pathways |
| GO:0038094 | 0.00677983410628 | 0.428571428571 | YES1 FYN LYN | Fc-gamma receptor signaling pathway |
| REAC:R-HSA-5621575 | 0.00721110026367 | 0.285714285714 | LYN FYN | CD209 (DC-SIGN) signaling |
| GO:0002431 | 0.00870569405676 | 0.428571428571 | YES1 FYN LYN | Fc receptor mediated stimulatory signaling pathway |
| GO:0031295 | 0.00870569405676 | 0.428571428571 | YES1 FYN LYN | T cell costimulation |
| REAC:R-HSA-983695 | 0.0087631788483 | 0.285714285714 | LYN FYN | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| GO:0031294 | 0.00979189312029 | 0.428571428571 | YES1 FYN LYN | lymphocyte costimulation |
| REAC:R-HSA-109582 | 0.0102424024409 | 0.571428571429 | YES1 FYN S100A10 LYN | Hemostasis |
| WP:WP2332 | 0.0124193659106 | 0.285714285714 | YES1 FYN | Interleukin 11 signaling pathway |
| REAC:R-HSA-114604 | 0.0133002920771 | 0.285714285714 | LYN FYN | GPVI-mediated activation cascade |
| KEGG:04664 | 0.0139791020136 | 0.285714285714 | LYN FYN | Fc epsilon RI signaling pathway |
| GO:0004715 | 0.0150353457168 | 0.428571428571 | YES1 FYN LYN | non-membrane spanning protein tyrosine kinase activity |
| WP:WP286 | 0.0151967459334 | 0.285714285714 | LYN FYN | IL 3 signaling pathway |
| WP:WP304 | 0.0224576883083 | 0.285714285714 | LYN FYN | Kit receptor signaling pathway |
| GO:0002437 | 0.0305188440994 | 0.428571428571 | YES1 FYN LYN | inflammatory response to antigenic stimulus |
| GO:0048013 | 0.0305188440994 | 0.428571428571 | YES1 FYN LYN | ephrin receptor signaling pathway |
| GO:0038093 | 0.0329865610647 | 0.428571428571 | YES1 FYN LYN | Fc receptor signaling pathway |
| REAC:R-HSA-1227986 | 0.0340922297215 | 0.285714285714 | YES1 FYN | Signaling by ERBB2 |
| KEGG:04520 | 0.0367995848147 | 0.285714285714 | YES1 FYN | Adherens junction |
| KEGG:04611 | 0.047723469919 | 0.285714285714 | LYN FYN | Platelet activation |
| WP:WP23 | 0.0499136541057 | 0.285714285714 | LYN FYN | B cell receptor signaling pathway |
| CORUM:2910 | 0.0499958217778 | 0.142857142857 | LYN | PLC-gamma-2-Lyn-FcR-gamma complex |
| CORUM:2321 | 0.0499958217778 | 0.142857142857 | FYN | ITGA6-ITGB4-FYN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| YES1 | FYN | 0.998 | 0.114 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LYN | YES1 | 0.997 | 0.07 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| YES1 | CSNK1G3 | 0.997 | 0.126 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LYN | DSG2 | 0.997 | 0.26 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| FYN | DSG2 | 0.995 | 0.106 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| YES1 | DSG2 | 0.993 | 0.09 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| LYN | CSNK1G3 | 0.99 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GPRC5A | YES1 | 0.986 | 0.066 | hein_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| YES1 | S100A10 | 0.985 | 0.07 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LYN | FYN | 0.983 | 0.162 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GPRC5A | CSNK1G3 | 0.98 | 0.054 | hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LYN | S100A10 | 0.975 | 0.134615384615 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| DSG2 | S100A10 | 0.957 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| GPRC5A | LYN | 0.95 | 0.072 | hein_WMM bioplex3_WMM gupta_WMM WMM_only |
| GPRC5A | DSG2 | 0.939 | 0.178 | hein_WMM bioplex3_WMM gupta_WMM WMM_only |
| DSG2 | CSNK1G3 | 0.917 | 0.21 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| S100A10 | CSNK1G3 | 0.624 | 0.058 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FYN | S100A10 | 0.597 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FYN | CSNK1G3 | 0.38 | 0.136 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GPRC5A | S100A10 | 0.043 | 0.056 | hein_WMM bioplex3_WMM WMM_only |
| GPRC5A | FYN | 0.035 | 0.056 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes