hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05691.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRY2 | Cryptochrome-2 | 5 | UniProt NCBI |
| CRY1 | Cryptochrome-1 | 5 | UniProt NCBI |
| FBXL3 | F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A) | 5 | UniProt NCBI |
| PER3 | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04710 | 6.43837190005e-10 | 1.0 | CRY1 PER3 CRY2 FBXL3 | Circadian rhythm |
| GO:0043153 | 1.92476895832e-07 | 1.0 | CRY1 PER3 CRY2 FBXL3 | entrainment of circadian clock by photoperiod |
| GO:0009648 | 2.32998347586e-07 | 1.0 | CRY1 PER3 CRY2 FBXL3 | photoperiodism |
| GO:0009649 | 3.32854782266e-07 | 1.0 | CRY1 PER3 CRY2 FBXL3 | entrainment of circadian clock |
| WP:WP3594 | 6.13251770449e-07 | 1.0 | CRY1 PER3 CRY2 FBXL3 | Circadian rhythm genes |
| WP:WP3298 | 1.02110829143e-06 | 0.75 | CRY1 CRY2 PER3 | Melatonin metabolism and effects |
| CORUM:2773 | 3.07520988333e-05 | 0.5 | FBXL3 CRY2 | Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3) |
| CORUM:2772 | 3.07520988333e-05 | 0.5 | CRY1 FBXL3 | Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3) |
| GO:0042752 | 4.60223703929e-05 | 1.0 | CRY1 PER3 CRY2 FBXL3 | regulation of circadian rhythm |
| REAC:R-HSA-400253 | 5.03512663474e-05 | 0.75 | CRY1 CRY2 FBXL3 | Circadian Clock |
| GO:0007623 | 0.000317929863268 | 1.0 | CRY1 PER3 CRY2 FBXL3 | circadian rhythm |
| GO:0048511 | 0.000533101140219 | 1.0 | CRY1 PER3 CRY2 FBXL3 | rhythmic process |
| GO:0009416 | 0.00124298263937 | 1.0 | CRY1 PER3 CRY2 FBXL3 | response to light stimulus |
| WP:WP410 | 0.0020866894725 | 0.5 | CRY1 CRY2 | Exercise induced circadian regulation |
| GO:0009882 | 0.0028092043205 | 0.5 | CRY1 CRY2 | blue light photoreceptor activity |
| GO:0071483 | 0.0028092043205 | 0.5 | CRY1 CRY2 | cellular response to blue light |
| GO:0009785 | 0.0028092043205 | 0.5 | CRY1 CRY2 | blue light signaling pathway |
| GO:0009314 | 0.00467196972148 | 1.0 | CRY1 PER3 CRY2 FBXL3 | response to radiation |
| GO:0032922 | 0.0124631389739 | 0.75 | CRY1 CRY2 PER3 | circadian regulation of gene expression |
| GO:0009637 | 0.0168521501606 | 0.5 | CRY1 CRY2 | response to blue light |
| HP:0006979 | 0.0198386649826 | 0.5 | FBXL3 PER3 | Sleep-wake cycle disturbance |
| WP:WP5381 | 0.0245369062383 | 0.5 | CRY1 CRY2 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| HPA:0090183 | 0.0296286402726 | 0.75 | CRY1 CRY2 PER3 | cerebellum; cells in granular layer[High] |
| GO:2000323 | 0.042122686785 | 0.5 | CRY1 CRY2 | negative regulation of glucocorticoid receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CRY2 | CRY1 | 1.0 | 0.048 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FBXL3 | CRY2 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBXL3 | CRY1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CRY2 | PER3 | 0.984 | hein_WMM bioplex3_WMM hein () | |
| PER3 | CRY1 | 0.49 | bioplex3_WMM WMM_only |
Related Complexes