hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05700.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) | 5 | UniProt NCBI |
| BCL10 | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2753 | 1.70876175213e-06 | 1.0 | MALT1 BCL10 | FYB-CARMA1-BCL-10-MALT1 complex |
| CORUM:2752 | 1.70876175213e-06 | 1.0 | MALT1 BCL10 | CARMA1-BCL10-MALT1 complex |
| CORUM:2053 | 1.70876175213e-06 | 1.0 | MALT1 BCL10 | BCL10-MALT1 complex |
| CORUM:2054 | 1.02525705128e-05 | 1.0 | MALT1 BCL10 | CASP8-FADD-MALT1-BCL10 complex |
| CORUM:2745 | 1.70876175213e-05 | 1.0 | MALT1 BCL10 | Ubiquitin E3 ligase (TRAF6, TAB2, MALT1, UEV1A, BCL10) |
| CORUM:2055 | 1.70876175213e-05 | 1.0 | MALT1 BCL10 | CASP8-CHUK-IKBKB-MALT1-BCL10 complex |
| HP:0012123 | 2.05051410255e-05 | 1.0 | MALT1 BCL10 | Posterior uveitis |
| KEGG:04662 | 0.00037033376401 | 1.0 | MALT1 BCL10 | B cell receptor signaling pathway |
| HP:0012191 | 0.000410102820511 | 1.0 | MALT1 BCL10 | B-cell lymphoma |
| WP:WP3863 | 0.000500549133471 | 1.0 | MALT1 BCL10 | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| KEGG:04064 | 0.000513720234536 | 1.0 | MALT1 BCL10 | NF-kappa B signaling pathway |
| KEGG:04625 | 0.00058037380927 | 1.0 | MALT1 BCL10 | C-type lectin receptor signaling pathway |
| WP:WP5072 | 0.000586527811159 | 1.0 | MALT1 BCL10 | Modulators of TCR signaling and T cell activation |
| WP:WP69 | 0.000778915743411 | 1.0 | MALT1 BCL10 | T cell receptor signaling pathway |
| KEGG:04660 | 0.000853978605069 | 1.0 | MALT1 BCL10 | T cell receptor signaling pathway |
| HP:0100721 | 0.000943236487175 | 1.0 | MALT1 BCL10 | Mediastinal lymphadenopathy |
| WP:WP5098 | 0.00114964558631 | 1.0 | MALT1 BCL10 | T cell activation SARS CoV 2 |
| WP:WP23 | 0.00121306550203 | 1.0 | MALT1 BCL10 | B cell receptor signaling pathway |
| GO:0032449 | 0.00140460216025 | 1.0 | MALT1 BCL10 | CBM complex |
| KEGG:05152 | 0.001720800216 | 1.0 | MALT1 BCL10 | Tuberculosis |
| HP:0012539 | 0.00191723068589 | 1.0 | MALT1 BCL10 | Non-Hodgkin lymphoma |
| HP:0000554 | 0.00253238491666 | 1.0 | MALT1 BCL10 | Uveitis |
| HP:0045026 | 0.00266566833332 | 1.0 | MALT1 BCL10 | Abnormal mediastinum morphology |
| REAC:R-HSA-1169091 | 0.00355422444443 | 1.0 | MALT1 BCL10 | Activation of NF-kappaB in B cells |
| HP:0045027 | 0.0036943429081 | 1.0 | MALT1 BCL10 | Abnormality of the thoracic cavity |
| HP:0002113 | 0.0038549665128 | 1.0 | MALT1 BCL10 | Pulmonary infiltrates |
| KEGG:05131 | 0.00417007523294 | 1.0 | MALT1 BCL10 | Shigellosis |
| REAC:R-HSA-1168372 | 0.0046153654925 | 1.0 | MALT1 BCL10 | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-2871837 | 0.00474181386216 | 1.0 | MALT1 BCL10 | FCERI mediated NF-kB activation |
| REAC:R-HSA-202424 | 0.00669151102134 | 1.0 | MALT1 BCL10 | Downstream TCR signaling |
| REAC:R-HSA-5607764 | 0.00684359081728 | 1.0 | MALT1 BCL10 | CLEC7A (Dectin-1) signaling |
| HP:0000614 | 0.00688972738458 | 1.0 | MALT1 BCL10 | Abnormal nasolacrimal system morphology |
| REAC:R-HSA-983705 | 0.00779195358971 | 1.0 | MALT1 BCL10 | Signaling by the B Cell Receptor (BCR) |
| REAC:R-HSA-202403 | 0.0095092591506 | 1.0 | MALT1 BCL10 | TCR signaling |
| REAC:R-HSA-2454202 | 0.0104319904967 | 1.0 | MALT1 BCL10 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-5621481 | 0.0122005589102 | 1.0 | MALT1 BCL10 | C-type lectin receptors (CLRs) |
| HP:0002665 | 0.0183042558888 | 1.0 | MALT1 BCL10 | Lymphoma |
| HP:0031983 | 0.0239944325234 | 1.0 | MALT1 BCL10 | Abnormal pulmonary thoracic imaging finding |
| CORUM:2052 | 0.0249718442457 | 0.5 | BCL10 | BCL10 homo-oligomer complex |
| CORUM:2051 | 0.0249718442457 | 0.5 | MALT1 | MALT1 homo-oligomer complex |
| HP:0000975 | 0.0327774679293 | 1.0 | MALT1 BCL10 | Hyperhidrosis |
| HP:0004313 | 0.0440177027348 | 1.0 | MALT1 BCL10 | Decreased circulating antibody level |
| CORUM:2744 | 0.0499419797295 | 0.5 | MALT1 | TRAF2-MALT1 complex |
| CORUM:2743 | 0.0499419797295 | 0.5 | MALT1 | TRAF6-MALT1 complex |
| HP:0045038 | 0.0499436884913 | 0.5 | BCL10 | Gastric lymphoma |
| HP:0410386 | 0.0499436884913 | 0.5 | BCL10 | Decreased proportion of CD4-positive, alpha-beta memory T cells |
| HP:0410388 | 0.0499436884913 | 0.5 | BCL10 | Decreased proportion of central memory CD4-positive, alpha-beta T cells |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BCL10 | MALT1 | 0.998 | 0.226 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes