hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05708.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAD2L1BP | MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet)) | 5 | UniProt NCBI |
| EPM2AIP1 | EPM2A-interacting protein 1 (Laforin-interacting protein) | 5 | UniProt NCBI |
| MAD1L1 | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | 5 | UniProt NCBI |
| PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-) | 5 | UniProt NCBI |
| PYM1 | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | 5 | UniProt NCBI |
| TPR | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0090233 | 0.0140440992017 | 0.4 | MAD2L1BP MAD1L1 | negative regulation of spindle checkpoint |
| GO:0140499 | 0.0140440992017 | 0.4 | MAD2L1BP MAD1L1 | negative regulation of mitotic spindle assembly checkpoint signaling |
| GO:1902426 | 0.0140440992017 | 0.4 | MAD2L1BP MAD1L1 | deactivation of mitotic spindle assembly checkpoint |
| CORUM:1813 | 0.0498708842806 | 0.2 | MAD1L1 | MAD1L1 homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAD1L1 | MAD2L1BP | 1.0 | 0.372 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 |
| MAD2L1BP | PYROXD1 | 0.997 | 0.146 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| PYM1 | MAD2L1BP | 0.986 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAD2L1BP | EPM2AIP1 | 0.985 | 0.024 | hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TPR | MAD2L1BP | 0.956 | 0.202 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| EPM2AIP1 | PYROXD1 | 0.902 | 0.03 | bioplex3_WMM WMM_only |
| MAD1L1 | TPR | 0.901 | 0.398 | hein_WMM bioplex_WMM Guru bioplex3_WMM fraction |
| MAD1L1 | PYROXD1 | 0.892 | 0.126 | bioplex3_WMM WMM_only |
| MAD1L1 | EPM2AIP1 | 0.889 | 0.03 | hein_WMM bioplex3_WMM WMM_only |
| TPR | EPM2AIP1 | 0.862 | 0.064 | hein_WMM bioplex3_WMM WMM_only |
| TPR | PYROXD1 | 0.293 | 0.15 | bioplex3_WMM WMM_only |
| PYM1 | PYROXD1 | 0.123 | 0.092 | bioplex3_WMM WMM_only |
| MAD1L1 | PYM1 | 0.111 | 0.072 | bioplex3_WMM WMM_only |
| PYM1 | EPM2AIP1 | 0.058 | 0.036 | bioplex3_WMM WMM_only |
| PYM1 | TPR | 0.052 | 0.134 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes