hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05712.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RGPD5 | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | 4 | UniProt NCBI |
| NUP62 | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | 5 | UniProt NCBI |
| SUMO1 | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | 5 | UniProt NCBI |
| RANBP2 | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | 5 | UniProt NCBI |
| NXF1 | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 9.59218740742e-08 | 1.0 | RANBP2 NXF1 NUP62 SUMO1 | Nucleocytoplasmic transport |
| REAC:R-HSA-159227 | 6.29837429836e-06 | 0.75 | RANBP2 NUP62 NXF1 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-159230 | 6.94957302308e-06 | 0.75 | RANBP2 NUP62 NXF1 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-4085377 | 6.94957302308e-06 | 0.75 | RANBP2 NUP62 SUMO1 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-3232142 | 9.16893973468e-06 | 0.75 | RANBP2 NUP62 SUMO1 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-159231 | 1.18162330858e-05 | 0.75 | RANBP2 NUP62 NXF1 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 1.28002609524e-05 | 0.75 | RANBP2 NUP62 NXF1 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-4615885 | 1.60766305396e-05 | 0.75 | RANBP2 NUP62 SUMO1 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 1.72814889866e-05 | 0.75 | RANBP2 NUP62 SUMO1 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4551638 | 6.40033583955e-05 | 0.75 | RANBP2 NUP62 SUMO1 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-159236 | 7.65476877178e-05 | 0.75 | RANBP2 NUP62 NXF1 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 7.99206750774e-05 | 0.75 | RANBP2 NUP62 SUMO1 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-72202 | 0.000110531761496 | 0.75 | RANBP2 NUP62 NXF1 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-3108232 | 0.000897810107574 | 0.75 | RANBP2 NUP62 SUMO1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.000986096194174 | 0.75 | RANBP2 NUP62 SUMO1 | SUMOylation |
| REAC:R-HSA-913531 | 0.00122110889015 | 0.75 | RANBP2 NUP62 SUMO1 | Interferon Signaling |
| KEGG:05014 | 0.00189623846113 | 0.75 | RANBP2 NUP62 NXF1 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-68882 | 0.00252982363853 | 0.75 | RANBP2 NUP62 SUMO1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00256403202009 | 0.75 | RANBP2 NUP62 SUMO1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-9615933 | 0.00282403231951 | 0.5 | NUP62 SUMO1 | Postmitotic nuclear pore complex (NPC) reformation |
| GO:0006913 | 0.00366770658506 | 1.0 | RANBP2 NXF1 NUP62 SUMO1 | nucleocytoplasmic transport |
| GO:0051169 | 0.00366770658506 | 1.0 | RANBP2 NXF1 NUP62 SUMO1 | nuclear transport |
| REAC:R-HSA-170822 | 0.00386628370571 | 0.5 | RANBP2 NUP62 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 0.00386628370571 | 0.5 | RANBP2 NUP62 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168271 | 0.00415229579539 | 0.5 | RANBP2 NUP62 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168333 | 0.00415229579539 | 0.5 | RANBP2 NUP62 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 0.00415229579539 | 0.5 | RANBP2 NUP62 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-9694516 | 0.00464100691605 | 0.75 | RANBP2 NUP62 SUMO1 | SARS-CoV-2 Infection |
| REAC:R-HSA-72203 | 0.00469213914253 | 0.75 | RANBP2 NUP62 NXF1 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-180910 | 0.00475483947495 | 0.5 | RANBP2 NUP62 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-180746 | 0.00475483947495 | 0.5 | RANBP2 NUP62 | Nuclear import of Rev protein |
| REAC:R-HSA-165054 | 0.00507136546841 | 0.5 | RANBP2 NUP62 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 0.00539805716719 | 0.5 | RANBP2 NUP62 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 0.00573491177379 | 0.5 | RANBP2 NUP62 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 0.00573491177379 | 0.5 | RANBP2 NUP62 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-168276 | 0.0068064250699 | 0.5 | RANBP2 NUP62 | NS1 Mediated Effects on Host Pathways |
| HPA:0301371 | 0.00711777470095 | 1.0 | RANBP2 NXF1 NUP62 SUMO1 | lung; alveolar cells type II[>=Low] |
| REAC:R-HSA-168325 | 0.0079693038543 | 0.5 | RANBP2 NUP62 | Viral Messenger RNA Synthesis |
| WP:WP3998 | 0.00862655865142 | 0.5 | RANBP2 NUP62 | Prader Willi and Angelman syndrome |
| REAC:R-HSA-2980766 | 0.0110375739361 | 0.5 | RANBP2 NUP62 | Nuclear Envelope Breakdown |
| REAC:R-HSA-9679506 | 0.0120967178818 | 0.75 | RANBP2 NUP62 SUMO1 | SARS-CoV Infections |
| REAC:R-HSA-194441 | 0.0130136556072 | 0.5 | RANBP2 NUP62 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 0.0130136556072 | 0.5 | RANBP2 NUP62 | snRNP Assembly |
| REAC:R-HSA-68886 | 0.0131851712206 | 0.75 | RANBP2 NUP62 SUMO1 | M Phase |
| REAC:R-HSA-6784531 | 0.0151515389193 | 0.5 | RANBP2 NUP62 | tRNA processing in the nucleus |
| REAC:R-HSA-3371453 | 0.0212029570934 | 0.5 | RANBP2 NUP62 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.0212029570934 | 0.5 | RANBP2 NUP62 | Glycolysis |
| REAC:R-HSA-1169408 | 0.0218635493976 | 0.5 | RANBP2 NUP62 | ISG15 antiviral mechanism |
| REAC:R-HSA-2995410 | 0.022534212454 | 0.5 | NUP62 SUMO1 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-5619102 | 0.0246065982605 | 0.5 | RANBP2 NUP62 | SLC transporter disorders |
| CORUM:7567 | 0.0249718442456 | 0.25 | SUMO1 | SUMO1-SYT7 complex |
| HP:0010994 | 0.0259951101914 | 0.5 | RANBP2 NUP62 | Abnormal corpus striatum morphology |
| REAC:R-HSA-1169410 | 0.0260384914588 | 0.5 | RANBP2 NUP62 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-70326 | 0.0313666733646 | 0.5 | RANBP2 NUP62 | Glucose metabolism |
| REAC:R-HSA-69278 | 0.0329329593357 | 0.75 | RANBP2 NUP62 SUMO1 | Cell Cycle, Mitotic |
| GO:0005643 | 0.0351813641256 | 0.75 | RANBP2 NUP62 SUMO1 | nuclear pore |
| REAC:R-HSA-3371556 | 0.0363250695065 | 0.5 | RANBP2 NUP62 | Cellular response to heat stress |
| HPA:0300201 | 0.0401447172992 | 0.75 | RANBP2 SUMO1 NXF1 | lung; endothelial cells[>=Low] |
| REAC:R-HSA-5578749 | 0.041644107744 | 0.5 | RANBP2 NUP62 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-9610379 | 0.0492961191682 | 0.5 | RANBP2 NUP62 | HCMV Late Events |
| REAC:R-HSA-72306 | 0.0492961191682 | 0.5 | RANBP2 NUP62 | tRNA processing |
| CORUM:1056 | 0.049938562206 | 0.25 | SUMO1 | ZNF198-SUMO1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RANBP2 | SUMO1 | 0.999 | 0.44 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| RGPD5 | SUMO1 | 0.997 | 0.104 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NUP62 | SUMO1 | 0.993 | 0.62 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| NXF1 | RANBP2 | 0.992 | 0.606 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| NXF1 | NUP62 | 0.992 | 0.558 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NUP62 | RANBP2 | 0.992 | 0.692 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| RANBP2 | RGPD5 | 0.991 | 0.224 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| NUP62 | RGPD5 | 0.99 | 0.172 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| NXF1 | RGPD5 | 0.961 | 0.248 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| NXF1 | SUMO1 | 0.946 | 0.144 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
Related Complexes