hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05713.1
Complex Portal: CPX-11143
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WDR87 | WD repeat-containing protein 87 (Testis development protein NYD-SP11) | 3 | UniProt NCBI |
| HDAC3 | Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45) | 5 | UniProt NCBI |
| SETD5 | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | 5 | UniProt NCBI |
| NCOR1 | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | 5 | UniProt NCBI |
| TBL1Y | F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked) | 5 | UniProt NCBI |
| TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) | 5 | UniProt NCBI |
| NCOR2 | Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) | 5 | UniProt NCBI |
| ANKRD11 | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | 5 | UniProt NCBI |
| GPS2 | G protein pathway suppressor 2 (GPS-2) | 5 | UniProt NCBI |
| TBL1X | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9022537 | 3.75149457555e-18 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Loss of MECP2 binding ability to the NCoR/SMRT complex |
| REAC:R-HSA-9675151 | 7.87074495244e-16 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Disorders of Developmental Biology |
| REAC:R-HSA-9697154 | 7.87074495244e-16 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Disorders of Nervous System Development |
| REAC:R-HSA-9005895 | 7.87074495244e-16 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Pervasive developmental disorders |
| REAC:R-HSA-9005891 | 7.87074495244e-16 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Loss of function of MECP2 in Rett syndrome |
| CORUM:58 | 3.31256423358e-15 | 0.5 | TBL1X GPS2 HDAC3 NCOR2 TBL1XR1 | SMRT complex |
| CORUM:741 | 3.31256423358e-15 | 0.5 | TBL1X NCOR1 HDAC3 GPS2 TBL1XR1 | NCOR-HDAC3 complex |
| CORUM:15 | 1.98697170849e-14 | 0.5 | TBL1X NCOR1 HDAC3 GPS2 TBL1XR1 | NCOR complex |
| CORUM:2183 | 8.33576398994e-13 | 0.5 | TBL1X NCOR1 HDAC3 GPS2 TBL1XR1 | Kaiso-NCOR complex |
| REAC:R-HSA-9022692 | 1.7724347993e-12 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 2.745982912e-12 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-9024446 | 1.21451913384e-11 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-8986944 | 8.51787906811e-11 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-350054 | 2.87272883513e-10 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Notch-HLH transcription pathway |
| REAC:R-HSA-3214815 | 1.10787467312e-09 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | HDACs deacetylate histones |
| WP:WP4312 | 3.75979100467e-09 | 0.5 | TBL1X NCOR1 TBL1XR1 GPS2 NCOR2 | Rett syndrome causing genes |
| REAC:R-HSA-1989781 | 4.11266564213e-09 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | PPARA activates gene expression |
| REAC:R-HSA-400206 | 4.37414413237e-09 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Regulation of lipid metabolism by PPARalpha |
| REAC:R-HSA-2122947 | 7.14128465607e-09 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9609690 | 1.33403358267e-08 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | HCMV Early Events |
| REAC:R-HSA-2644602 | 1.66143924879e-08 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2894858 | 1.66143924879e-08 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 1.66143924879e-08 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2644606 | 1.66143924879e-08 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 1.66143924879e-08 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| CORUM:752 | 1.68385473419e-08 | 0.3 | TBL1X HDAC3 NCOR2 | SMRT core complex |
| CORUM:7480 | 1.68385473419e-08 | 0.3 | NCOR1 HDAC3 NCOR2 | HDAC3-H1.3-SMRT-N-Cor complex |
| CORUM:1188 | 1.68385473419e-08 | 0.3 | TBL1X HDAC3 NCOR2 | SMRT core complex |
| GO:0017053 | 3.10496880868e-08 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | transcription repressor complex |
| REAC:R-HSA-9609646 | 3.7171214705e-08 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | HCMV Infection |
| REAC:R-HSA-9707564 | 5.40394138347e-08 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Cytoprotection by HMOX1 |
| REAC:R-HSA-1980143 | 5.40394138347e-08 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Signaling by NOTCH1 |
| GO:0000118 | 5.74335817737e-08 | 0.6 | TBL1Y SETD5 TBL1XR1 HDAC3 NCOR1 TBL1X | histone deacetylase complex |
| GO:0003714 | 9.22338637712e-08 | 0.7 | TBL1Y NCOR1 TBL1XR1 NCOR2 HDAC3 GPS2 TBL1X | transcription corepressor activity |
| REAC:R-HSA-381340 | 1.85448601131e-07 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Transcriptional regulation of white adipocyte differentiation |
| CORUM:1505 | 5.88502576438e-07 | 0.3 | NCOR1 HDAC3 NCOR2 | NCOR2 complex |
| REAC:R-HSA-9006931 | 1.05135977554e-06 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Signaling by Nuclear Receptors |
| REAC:R-HSA-3247509 | 1.13037097807e-06 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 1.13037097807e-06 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Chromatin organization |
| REAC:R-HSA-9707616 | 2.95075305606e-06 | 0.4 | TBL1X NCOR1 HDAC3 TBL1XR1 | Heme signaling |
| REAC:R-HSA-2151201 | 5.11949202063e-06 | 0.4 | TBL1X NCOR1 HDAC3 TBL1XR1 | Transcriptional activation of mitochondrial biogenesis |
| REAC:R-HSA-400253 | 1.36716025886e-05 | 0.4 | TBL1X NCOR1 HDAC3 TBL1XR1 | Circadian Clock |
| CORUM:5614 | 1.62229842182e-05 | 0.3 | TBL1XR1 HDAC3 TBL1Y | Emerin complex 32 |
| REAC:R-HSA-9711123 | 1.68609099646e-05 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Cellular response to chemical stress |
| REAC:R-HSA-157118 | 2.90156143749e-05 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Signaling by NOTCH |
| CORUM:5426 | 3.07577115383e-05 | 0.2 | ANKRD11 HDAC3 | ANCO1-HDAC3 complex |
| REAC:R-HSA-1592230 | 5.5176603535e-05 | 0.4 | TBL1X NCOR1 HDAC3 TBL1XR1 | Mitochondrial biogenesis |
| GO:0003712 | 8.16141430501e-05 | 0.7 | TBL1Y NCOR1 TBL1XR1 NCOR2 HDAC3 GPS2 TBL1X | transcription coregulator activity |
| REAC:R-HSA-556833 | 0.000231143371219 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Metabolism of lipids |
| REAC:R-HSA-1368071 | 0.000305236852181 | 0.2 | NCOR1 HDAC3 | NR1D1 (REV-ERBA) represses gene expression |
| REAC:R-HSA-9824446 | 0.000521039877845 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Viral Infection Pathways |
| REAC:R-HSA-5663202 | 0.000562417280387 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Diseases of signal transduction by growth factor receptors and second messengers |
| CORUM:1413 | 0.00138006084651 | 0.2 | NCOR1 HDAC3 | NCOR1 complex |
| REAC:R-HSA-5663205 | 0.00173306517432 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Infectious disease |
| GO:0005667 | 0.00203626128474 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | transcription regulator complex |
| REAC:R-HSA-9623433 | 0.0036548283771 | 0.2 | NCOR1 NCOR2 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
| REAC:R-HSA-212436 | 0.00465548020126 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Generic Transcription Pathway |
| GO:0030674 | 0.00523305555838 | 0.7 | TBL1Y NCOR1 TBL1XR1 NCOR2 HDAC3 GPS2 TBL1X | protein-macromolecule adaptor activity |
| REAC:R-HSA-1852241 | 0.00569008336058 | 0.4 | TBL1X NCOR1 HDAC3 TBL1XR1 | Organelle biogenesis and maintenance |
| KEGG:04310 | 0.00607352270743 | 0.3 | TBL1X TBL1Y TBL1XR1 | Wnt signaling pathway |
| HPA:0490692 | 0.00658528587788 | 0.8 | SETD5 TBL1XR1 NCOR2 HDAC3 GPS2 NCOR1 ANKRD11 TBL1X | smooth muscle; smooth muscle cells[>=Medium] |
| REAC:R-HSA-73857 | 0.0087488365386 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | RNA Polymerase II Transcription |
| REAC:R-HSA-1368082 | 0.0121516690115 | 0.2 | TBL1XR1 TBL1X | RORA activates gene expression |
| REAC:R-HSA-2262752 | 0.0144474363473 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0151311453833 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Cellular responses to stimuli |
| GO:0060090 | 0.0153657945934 | 0.7 | TBL1Y NCOR1 TBL1XR1 NCOR2 HDAC3 GPS2 TBL1X | molecular adaptor activity |
| REAC:R-HSA-74160 | 0.0179061878456 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Gene expression (Transcription) |
| HPA:0170251 | 0.01801812664 | 0.8 | SETD5 TBL1XR1 NCOR2 HDAC3 GPS2 NCOR1 ANKRD11 TBL1X | endometrium 2; cells in endometrial stroma[>=Low] |
| REAC:R-HSA-1368108 | 0.0255543807721 | 0.2 | TBL1XR1 TBL1X | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| HPA:0630222 | 0.0275567288858 | 0.8 | SETD5 TBL1XR1 NCOR2 HDAC3 GPS2 NCOR1 ANKRD11 TBL1X | cervix; squamous epithelial cells[>=Medium] |
| REAC:R-HSA-1266738 | 0.032020162516 | 0.5 | TBL1X NCOR1 HDAC3 NCOR2 TBL1XR1 | Developmental Biology |
| HPA:0170252 | 0.0342710299931 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 ANKRD11 TBL1X | endometrium 2; cells in endometrial stroma[>=Medium] |
| REAC:R-HSA-1643685 | 0.0385148593027 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | Disease |
| WP:WP61 | 0.0386378382776 | 0.2 | NCOR1 NCOR2 | Notch signaling pathway |
| REAC:R-HSA-2173795 | 0.0409184848695 | 0.2 | NCOR1 NCOR2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| GO:0000122 | 0.0497136062027 | 0.6 | NCOR1 NCOR2 TBL1XR1 HDAC3 GPS2 TBL1X | negative regulation of transcription by RNA polymerase II |
| REAC:R-HSA-383280 | 0.0499343626014 | 0.2 | NCOR1 NCOR2 | Nuclear Receptor transcription pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NCOR1 | GPS2 | 1.0 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| NCOR2 | GPS2 | 1.0 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| TBL1XR1 | GPS2 | 1.0 | 0.166 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GPS2 | HDAC3 | 1.0 | 0.2296 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| GPS2 | TBL1X | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NCOR2 | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ANKRD11 | GPS2 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| GPS2 | TBL1Y | 0.999 |
mutually_exclusive (Q9BZK7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBL1X | TBL1Y | 0.999 |
mutually_exclusive (Q9BZK7)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NCOR1 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| HDAC3 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TBL1XR1 | TBL1Y | 0.998 |
mutually_exclusive (O60907)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR87 | GPS2 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SETD5 | GPS2 | 0.986 | 0.132 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| NCOR1 | TBL1XR1 | 0.969 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SETD5 | TBL1XR1 | 0.967 | 0.112 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_WMM youn_WMM hein () |
| NCOR1 | HDAC3 | 0.959 | 0.28 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| NCOR2 | TBL1X | 0.955 | 0.216 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ANKRD11 | TBL1X | 0.954 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ANKRD11 | HDAC3 | 0.952 | 0.366 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCOR1 | TBL1X | 0.95 | 0.154 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TBL1XR1 | HDAC3 | 0.948 | 0.304 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| NCOR2 | ANKRD11 | 0.92 | 0.288 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCOR2 | HDAC3 | 0.919 | 0.4 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TBL1XR1 | ANKRD11 | 0.913 | 0.134 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TBL1XR1 | TBL1X | 0.91 | 0.954 |
mutually_exclusive (Q9BQ87)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| WDR87 | ANKRD11 | 0.908 | bioplex3_WMM WMM_only | ||
| TBL1X | HDAC3 | 0.892 | 0.4 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TBL1XR1 | NCOR2 | 0.89 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| WDR87 | NCOR2 | 0.89 | bioplex3_WMM WMM_only | ||
| SETD5 | NCOR2 | 0.89 | 0.296333333333 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| SETD5 | ANKRD11 | 0.885 | 0.16 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| NCOR1 | ANKRD11 | 0.885 | 0.242 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SETD5 | NCOR1 | 0.862 | 0.209 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| SETD5 | WDR87 | 0.768 | bioplex3_WMM WMM_only | ||
| WDR87 | TBL1X | 0.715 | bioplex3_WMM WMM_only | ||
| NCOR1 | NCOR2 | 0.676 | 0.19 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| WDR87 | NCOR1 | 0.675 | bioplex3_WMM WMM_only | ||
| WDR87 | TBL1XR1 | 0.654 | bioplex3_WMM WMM_only | ||
| WDR87 | HDAC3 | 0.312 | bioplex3_WMM WMM_only | ||
| SETD5 | TBL1X | 0.258 | 0.046 | bioplex3_WMM youn_WMM WMM_only | |
| SETD5 | HDAC3 | 0.097 | 0.198 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes