hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05716.1
Complex Portal: CPX-11978
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRRCC1 | Leucine-rich repeat and coiled-coil domain-containing protein 1 (Centrosomal leucine-rich repeat and coiled-coil domain-containing protein) | 4 | UniProt NCBI |
| CEP68 | Centrosomal protein of 68 kDa (Cep68) | 5 | UniProt NCBI |
| PCM1 | Pericentriolar material 1 protein (PCM-1) (hPCM-1) | 5 | UniProt NCBI |
| PCNT | Pericentrin (Kendrin) (Pericentrin-B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4656 | 0.0063063631888 | 0.5 | PCNT PCM1 | Joubert syndrome |
| REAC:R-HSA-380259 | 0.0218635493976 | 0.5 | PCNT PCM1 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.0218635493976 | 0.5 | PCNT PCM1 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.0239057396727 | 0.5 | PCNT PCM1 | AURKA Activation by TPX2 |
| REAC:R-HSA-380287 | 0.0305753786405 | 0.5 | PCNT PCM1 | Centrosome maturation |
| REAC:R-HSA-380270 | 0.0305753786405 | 0.5 | PCNT PCM1 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-2565942 | 0.0346321697685 | 0.5 | PCNT PCM1 | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-380320 | 0.0407325822829 | 0.5 | PCNT PCM1 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-5620912 | 0.0434971593242 | 0.5 | PCNT PCM1 | Anchoring of the basal body to the plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PCM1 | PCNT | 0.995 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | ||
| PCM1 | CEP68 | 0.991 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| CEP68 | PCNT | 0.981 | 0.132 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| LRRCC1 | PCM1 | 0.98 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | ||
| LRRCC1 | PCNT | 0.008 | gupta_WMM WMM_only |
Related Complexes