hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05718.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
COL21A1	Collagen alpha-1(XXI) chain	5	UniProt NCBI
COL5A2	Collagen alpha-2(V) chain	5	UniProt NCBI
PLOD3	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]	5	UniProt NCBI
COL9A2	Collagen alpha-2(IX) chain	5	UniProt NCBI
RITA1	RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein)	5	UniProt NCBI
COL5A1	Collagen alpha-1(V) chain	5	UniProt NCBI
COLGALT1	Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (ColGalT 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1650814	2.03707115154e-12	0.857142857143	PLOD3 COL21A1 COL5A1 COL5A2 COLGALT1 COL9A2	Collagen biosynthesis and modifying enzymes
REAC:R-HSA-1474290	1.56148526259e-11	0.857142857143	PLOD3 COL21A1 COL5A1 COL5A2 COLGALT1 COL9A2	Collagen formation
REAC:R-HSA-1474244	1.80805568166e-08	0.857142857143	PLOD3 COL21A1 COL5A1 COL5A2 COLGALT1 COL9A2	Extracellular matrix organization
REAC:R-HSA-8948216	9.74061410063e-08	0.571428571429	COL5A1 COL9A2 COL21A1 COL5A2	Collagen chain trimerization
KEGG:04974	8.22219086806e-07	0.571428571429	COL5A1 COL9A2 COL21A1 COL5A2	Protein digestion and absorption
HP:0025019	3.18986349491e-06	0.428571428571	COL5A1 COL5A2 PLOD3	Arterial rupture
GO:0030020	2.17835957927e-05	0.571428571429	COL5A1 COL9A2 COL21A1 COL5A2	extracellular matrix structural constituent conferring tensile strength
REAC:R-HSA-419037	3.79530741097e-05	0.428571428571	COL5A1 COL5A2 COL9A2	NCAM1 interactions
CORUM:6997	6.1565588648e-05	0.285714285714	COLGALT1 PLOD3	ADIPOQ-PLOD3-GLT25D1 complex
GO:0030199	6.76004009067e-05	0.571428571429	COL5A1 COL5A2 COLGALT1 PLOD3	collagen fibril organization
REAC:R-HSA-375165	0.00014849904315	0.428571428571	COL5A1 COL5A2 COL9A2	NCAM signaling for neurite out-growth
REAC:R-HSA-2022090	0.000209532838622	0.428571428571	COL5A1 COL5A2 COL9A2	Assembly of collagen fibrils and other multimeric structures
GO:0030198	0.000219456984395	0.714285714286	COL5A1 COL9A2 COL5A2 COLGALT1 PLOD3	extracellular matrix organization
GO:0043062	0.000219456984395	0.714285714286	COL5A1 COL9A2 COL5A2 COLGALT1 PLOD3	extracellular structure organization
REAC:R-HSA-186797	0.000223455724258	0.428571428571	COL5A1 COL5A2 COL9A2	Signaling by PDGF
GO:0045229	0.000232620911116	0.714285714286	COL5A1 COL9A2 COL5A2 COLGALT1 PLOD3	external encapsulating structure organization
REAC:R-HSA-1442490	0.000237979963395	0.428571428571	COL5A1 COL5A2 COL9A2	Collagen degradation
HP:0025323	0.000292522016748	0.571428571429	COL5A1 COL5A2 COLGALT1 PLOD3	Abnormal arterial physiology
REAC:R-HSA-3000178	0.000397824819576	0.428571428571	COL5A1 COL5A2 COL9A2	ECM proteoglycans
HP:0025014	0.000499829101057	0.285714285714	COL5A1 COL5A2	Subcutaneous spheroids
HP:0025509	0.000499829101057	0.285714285714	COL5A1 COL5A2	Piezogenic pedal papules
REAC:R-HSA-216083	0.000511465276813	0.428571428571	COL5A1 COL5A2 COL9A2	Integrin cell surface interactions
HP:0004944	0.000802165341459	0.428571428571	COL5A1 COL5A2 PLOD3	Dilatation of the cerebral artery
HP:0002758	0.000802165341459	0.428571428571	COL5A1 COL5A2 COL9A2	Osteoarthritis
HP:0030009	0.000999430167489	0.285714285714	COL5A1 COL5A2	Cervical insufficiency
HP:0004872	0.000999430167489	0.285714285714	COL5A1 COL5A2	Incisional hernia
HP:0009763	0.00104065814502	0.428571428571	COL5A1 COL5A2 COL9A2	Limb pain
GO:0005788	0.00135274447935	0.714285714286	COL5A1 COL9A2 COL21A1 COLGALT1 COL5A2	endoplasmic reticulum lumen
HP:0003771	0.00166533696614	0.285714285714	COL5A1 COL5A2	Pulp calcification
HP:0000993	0.00166533696614	0.285714285714	COL5A1 COL5A2	Molluscoid pseudotumors
HP:0009811	0.00176796171535	0.571428571429	COL5A1 COL9A2 COL5A2 PLOD3	Abnormality of the elbow
REAC:R-HSA-1474228	0.00239362555724	0.428571428571	COL5A1 COL5A2 COL9A2	Degradation of the extracellular matrix
HP:0006243	0.00249743559672	0.285714285714	COL5A1 COL5A2	Phalangeal dislocation
HP:0010749	0.00249743559672	0.285714285714	COL5A1 COL5A2	Blepharochalasis
HP:0100823	0.00249743559672	0.285714285714	COL5A1 COL5A2	Genital hernia
HP:0000139	0.00249743559672	0.285714285714	COL5A1 COL5A2	Uterine prolapse
WP:WP2911	0.00271530250843	0.285714285714	COL5A1 COL5A2	miRNA targets in ECM and membrane receptors
HP:0009145	0.00307859089363	0.428571428571	COL5A1 COL5A2 PLOD3	Abnormal cerebral artery morphology
HP:0010750	0.00349561220575	0.285714285714	COL5A1 COL5A2	Dermatochalasis
HP:0030163	0.00358121595245	0.571428571429	COL5A1 COL5A2 COLGALT1 PLOD3	Abnormal vascular physiology
HP:0100659	0.00485178840606	0.571428571429	COL5A1 COL5A2 COLGALT1 PLOD3	Abnormal cerebral vascular morphology
GO:0005581	0.00593357407009	0.428571428571	COL5A1 COL5A2 COL9A2	collagen trimer
HP:0004947	0.00598974417902	0.285714285714	COL5A1 COL5A2	Arteriovenous fistula
GO:0005201	0.00603498380297	0.571428571429	COL5A1 COL9A2 COL21A1 COL5A2	extracellular matrix structural constituent
HP:0001073	0.00748547207011	0.285714285714	COL5A1 COL5A2	Cigarette-paper scars
HP:0003045	0.00750148885379	0.428571428571	COL5A1 COL5A2 COL9A2	Abnormal patella morphology
KEGG:00514	0.00793622460548	0.285714285714	COLGALT1 PLOD3	Other types of O-glycan biosynthesis
REAC:R-HSA-3000170	0.0087631788483	0.285714285714	COL5A1 COL5A2	Syndecan interactions
GO:0005588	0.00983221512175	0.285714285714	COL5A1 COL5A2	collagen type V trimer
GO:1903225	0.00983221512175	0.285714285714	COL5A1 COL5A2	negative regulation of endodermal cell differentiation
REAC:R-HSA-8874081	0.0104655132242	0.285714285714	COL5A1 COL5A2	MET activates PTK2 signaling
HP:0012888	0.0109736833289	0.285714285714	COL5A1 COL5A2	Abnormal uterine cervix morphology
HP:0005294	0.0109736833289	0.285714285714	COL5A1 COL5A2	Arterial dissection
HP:0001027	0.0109736833289	0.285714285714	COL5A1 COL5A2	Soft, doughy skin
HP:0001704	0.0129659395038	0.285714285714	COL5A1 COL5A2	Tricuspid valve prolapse
HP:0010754	0.0151234779917	0.285714285714	COL5A1 COL5A2	Abnormality of the temporomandibular joint
KEGG:00310	0.0167496959508	0.285714285714	COLGALT1 PLOD3	Lysine degradation
HP:0003834	0.0174461853129	0.285714285714	COL5A1 COL5A2	Shoulder dislocation
HP:0001788	0.0199339480346	0.285714285714	COL5A1 COL5A2	Premature rupture of membranes
REAC:R-HSA-8875878	0.0212237900738	0.285714285714	COL5A1 COL5A2	MET promotes cell motility
HP:0009810	0.0292411387003	0.571428571429	COL5A1 COL9A2 COL5A2 PLOD3	Abnormality of upper limb joint
HP:0000978	0.0292982733881	0.428571428571	COL5A1 COL5A2 PLOD3	Bruising susceptibility
GO:0050211	0.0294899169624	0.285714285714	COLGALT1 PLOD3	procollagen galactosyltransferase activity
REAC:R-HSA-3000171	0.0425383740248	0.285714285714	COL5A1 COL5A2	Non-integrin membrane-ECM interactions

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PLOD3	COLGALT1	1.0	0.55	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
COL5A1	PLOD3	0.996	0.166	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
COL5A1	COLGALT1	0.992	0.118	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
COL5A2	COL5A1	0.991	0.444	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
COL9A2	PLOD3	0.982		bioplex3_WMM bioplex3_HCT116 WMM_only
PLOD3	RITA1	0.972		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RITA1	COLGALT1	0.963		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
COL21A1	PLOD3	0.957		bioplex3_HEK293 bioplex3_WMM WMM_only
COL5A2	PLOD3	0.956	0.112	hein_WMM bioplex3_WMM gupta_WMM WMM_only
COL5A2	COLGALT1	0.952	0.132	hein_WMM bioplex3_WMM WMM_only
COL21A1	COLGALT1	0.947		bioplex3_HEK293 bioplex3_WMM WMM_only
COL9A2	COLGALT1	0.65		bioplex3_WMM WMM_only
COL5A1	COL21A1	0.113		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
COL21A1	huMAP3_02991.1 huMAP3_03726.1 huMAP3_05718.1 huMAP3_06974.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_13038.1
COL5A2	huMAP3_01608.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05229.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07100.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10095.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_14646.1
PLOD3	huMAP3_02991.1 huMAP3_03159.1 huMAP3_03726.1 huMAP3_05718.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1
COL9A2	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_05924.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1
RITA1	huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1 huMAP3_10984.1
COL5A1	huMAP3_01608.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05229.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07100.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10095.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1
COLGALT1	huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07149.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05718.1