hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05719.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACTN2 | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | 5 | UniProt NCBI |
| ACTN4 | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | 5 | UniProt NCBI |
| ACTN1 | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | 5 | UniProt NCBI |
| PDLIM1 | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | 5 | UniProt NCBI |
| HORMAD2 | HORMA domain-containing protein 2 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP383 | 0.00151495259867 | 0.5 | ACTN4 ACTN2 | Striated muscle contraction pathway |
| REAC:R-HSA-373753 | 0.00214930898727 | 0.5 | ACTN4 ACTN2 | Nephrin family interactions |
| WP:WP2118 | 0.00434689671613 | 0.5 | ACTN4 ACTN2 | Arrhythmogenic right ventricular cardiomyopathy |
| HPA:0570762 | 0.0115490191121 | 1.0 | ACTN4 HORMAD2 ACTN2 PDLIM1 | testis; pachytene spermatocytes[>=Medium] |
| GO:0030018 | 0.0192043220783 | 0.75 | ACTN4 ACTN2 PDLIM1 | Z disc |
| GO:0031674 | 0.0258660780327 | 0.75 | ACTN4 ACTN2 PDLIM1 | I band |
| HPA:0570761 | 0.0273327385677 | 1.0 | ACTN4 HORMAD2 ACTN2 PDLIM1 | testis; pachytene spermatocytes[>=Low] |
| CORUM:5655 | 0.049938562206 | 0.25 | ACTN4 | Ternary complex (LRRC7, CAMK2a, ACTN4) |
| CORUM:6362 | 0.049938562206 | 0.25 | PDLIM1 | PDLIM1-E-cadherin-beta-catenin complex |
| CORUM:6787 | 0.049938562206 | 0.25 | ACTN4 | NHE3-NHERF2-ACTN4, Ca(2+) induced |
| CORUM:6788 | 0.049938562206 | 0.25 | ACTN4 | SLC9A3R1-ACTN4 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDLIM1 | ACTN4 | 0.993 | 0.352 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| PDLIM1 | ACTN1 | 0.993 | 0.272 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ACTN1 | ACTN4 | 0.986 | 0.714 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| ACTN2 | PDLIM1 | 0.986 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PDLIM1 | HORMAD2 | 0.967 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACTN2 | ACTN1 | 0.589 | 0.25 | bioplex_WMM bioplex3_WMM WMM_only |
| ACTN2 | ACTN4 | 0.54 | 0.328325 | bioplex_WMM bioplex3_WMM WMM_only |
| HORMAD2 | ACTN4 | 0.109 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACTN2 | HORMAD2 | 0.027 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HORMAD2 | ACTN1 | 0.013 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes