hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05745.1
Complex Portal: CPX-15929
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCBP1 | Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) | 5 | UniProt NCBI |
| PAIP1 | Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1) | 5 | UniProt NCBI |
| MKRN2 | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | 5 | UniProt NCBI |
| PUM2 | Pumilio homolog 2 (Pumilio-2) | 5 | UniProt NCBI |
| PAIP2 | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) | 5 | UniProt NCBI |
| MKRN1 | E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) | 5 | UniProt NCBI |
| PAIP2B | Polyadenylate-binding protein-interacting protein 2B (PABP-interacting protein 2B) (PAIP-2B) (Poly(A)-binding protein-interacting protein 2B) | 4 | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | 5 | UniProt NCBI |
| PABPC1L | Polyadenylate-binding protein 1-like | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03015 | 0.000965229215008 | 0.333333333333 | PABPC1L NCBP1 GSPT2 | mRNA surveillance pathway |
| GO:0006446 | 0.00316270648564 | 0.444444444444 | PAIP2 PAIP2B NCBP1 PAIP1 | regulation of translational initiation |
| GO:0006413 | 0.0154150912184 | 0.444444444444 | PAIP2 PAIP2B NCBP1 PAIP1 | translational initiation |
| HPA:0570802 | 0.0162864298423 | 0.666666666667 | MKRN2 PUM2 PAIP1 PAIP2 NCBP1 GSPT2 | testis; sertoli cells[>=Medium] |
| GO:0045182 | 0.0185915423503 | 0.444444444444 | GSPT2 PAIP2 PAIP1 PAIP2B | translation regulator activity |
| WP:WP107 | 0.0356319901131 | 0.222222222222 | PAIP1 GSPT2 | Translation factors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PAIP1 | PAIP2 | 0.999 | 0.08 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PAIP1 | PAIP2B | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | ||
| NCBP1 | PAIP2B | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| NCBP1 | PAIP1 | 0.995 | 0.114 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| PUM2 | PAIP1 | 0.994 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | ||
| MKRN1 | PAIP2B | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PAIP2B | PAIP2 | 0.992 | youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PAIP1 | MKRN1 | 0.99 | 0.0713333333333 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| MKRN1 | GSPT2 | 0.987 | 0.09 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| NCBP1 | GSPT2 | 0.987 | 0.234 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PUM2 | PAIP2 | 0.986 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| MKRN2 | GSPT2 | 0.983 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PAIP1 | MKRN2 | 0.982 | 0.232 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| PUM2 | GSPT2 | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MKRN2 | PAIP2 | 0.973 | 0.128 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PAIP1 | GSPT2 | 0.961 | 0.246 |
mutually_exclusive (P0CB38)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PUM2 | PAIP2B | 0.96 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| NCBP1 | MKRN1 | 0.951 | 0.13 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MKRN2 | MKRN1 | 0.944 | 0.106 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MKRN2 | PAIP2B | 0.92 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| GSPT2 | PAIP2 | 0.915 | 0.17 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| PUM2 | NCBP1 | 0.879 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | ||
| NCBP1 | MKRN2 | 0.848 | 0.124 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MKRN1 | PAIP2 | 0.831 | 0.128 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCBP1 | PAIP2 | 0.824 | 0.074 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PUM2 | MKRN1 | 0.718 | bioplex3_WMM youn_WMM WMM_only | ||
| PUM2 | MKRN2 | 0.45 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes