hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05760.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CHSY1 | Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) | 5 | UniProt NCBI |
| DCN | Decorin (Bone proteoglycan II) (PG-S2) (PG40) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3595177 | 2.56314262819e-05 | 1.0 | CHSY1 DCN | Defective CHSY1 causes TPBS |
| REAC:R-HSA-2022870 | 0.00023239159829 | 1.0 | CHSY1 DCN | Chondroitin sulfate biosynthesis |
| REAC:R-HSA-3560782 | 0.00120125951175 | 1.0 | CHSY1 DCN | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-1793185 | 0.00176856841345 | 1.0 | CHSY1 DCN | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1630316 | 0.010244026704 | 1.0 | CHSY1 DCN | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 0.0106216630512 | 1.0 | CHSY1 DCN | Diseases of glycosylation |
| REAC:R-HSA-5668914 | 0.0297170756313 | 1.0 | CHSY1 DCN | Diseases of metabolism |
| KEGG:00532 | 0.0474849820587 | 0.5 | CHSY1 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
| HP:0010006 | 0.0499436884913 | 0.5 | CHSY1 | Duplication of the proximal phalanx of hand |
| HP:0010003 | 0.0499436884913 | 0.5 | CHSY1 | Partial duplication of the proximal phalanges of the hand |
| HP:0009970 | 0.0499436884913 | 0.5 | CHSY1 | Partial duplication of the proximal phalanx of the 3rd finger |
| HP:0009966 | 0.0499436884913 | 0.5 | CHSY1 | Complete duplication of the middle phalanx of the 3rd finger |
| HP:0007709 | 0.0499436884913 | 0.5 | DCN | Band-shaped corneal dystrophy |
| HP:0009963 | 0.0499436884913 | 0.5 | CHSY1 | Duplication of the middle phalanx of the 3rd finger |
| HP:0009960 | 0.0499436884913 | 0.5 | CHSY1 | Complete duplication of the phalanges of the 3rd finger |
| HP:0100345 | 0.0499436884913 | 0.5 | CHSY1 | Tibial deviation of the 2nd toe |
| HP:0009964 | 0.0499436884913 | 0.5 | CHSY1 | Duplication of the proximal phalanx of the 3rd finger |
| HP:0100347 | 0.0499436884913 | 0.5 | CHSY1 | Tibial deviation of the 5th toe |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DCN | CHSY1 | 0.98 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| CHSY1 | huMAP3_03662.1 huMAP3_05760.1 huMAP3_08868.1 huMAP3_09359.1 huMAP3_09688.1 |
| DCN | huMAP3_03039.1 huMAP3_05760.1 huMAP3_11818.1 |