hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05765.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BIRC2 | Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) | 5 | UniProt NCBI |
| DIABLO | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] | 5 | UniProt NCBI |
| LRRN2 | Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) | 4 | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04215 | 1.25269255935e-06 | 0.75 | XIAP BIRC2 DIABLO | Apoptosis - multiple species |
| WP:WP254 | 2.16610999348e-05 | 0.75 | XIAP BIRC2 DIABLO | Apoptosis |
| WP:WP1772 | 2.64882854506e-05 | 0.75 | XIAP BIRC2 DIABLO | Apoptosis modulation and signaling |
| KEGG:04210 | 9.58294361569e-05 | 0.75 | XIAP BIRC2 DIABLO | Apoptosis |
| REAC:R-HSA-111464 | 0.000153732433522 | 0.5 | XIAP DIABLO | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |
| REAC:R-HSA-111469 | 0.000153732433522 | 0.5 | XIAP DIABLO | SMAC, XIAP-regulated apoptotic response |
| REAC:R-HSA-111463 | 0.000153732433522 | 0.5 | XIAP DIABLO | SMAC (DIABLO) binds to IAPs |
| REAC:R-HSA-111458 | 0.000461028962628 | 0.5 | XIAP DIABLO | Formation of apoptosome |
| REAC:R-HSA-9627069 | 0.000461028962628 | 0.5 | XIAP DIABLO | Regulation of the apoptosome activity |
| REAC:R-HSA-111461 | 0.000676052383047 | 0.5 | XIAP DIABLO | Cytochrome c-mediated apoptotic response |
| REAC:R-HSA-109581 | 0.00104173974765 | 0.75 | XIAP BIRC2 DIABLO | Apoptosis |
| REAC:R-HSA-111471 | 0.0013924419067 | 0.5 | XIAP DIABLO | Apoptotic factor-mediated response |
| REAC:R-HSA-5357801 | 0.00166476808943 | 0.75 | XIAP BIRC2 DIABLO | Programmed Cell Death |
| REAC:R-HSA-5357786 | 0.00282403231951 | 0.5 | XIAP BIRC2 | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-5675482 | 0.00444848198459 | 0.5 | XIAP BIRC2 | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.00444848198459 | 0.5 | XIAP BIRC2 | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5357956 | 0.00507136546841 | 0.5 | XIAP BIRC2 | TNFR1-induced NF-kappa-B signaling pathway |
| KEGG:01524 | 0.00601982850302 | 0.5 | XIAP BIRC2 | Platinum drug resistance |
| KEGG:04064 | 0.00786967207033 | 0.5 | XIAP BIRC2 | NF-kappa B signaling pathway |
| WP:WP231 | 0.00883615359641 | 0.5 | BIRC2 DIABLO | TNF alpha signaling pathway |
| KEGG:05222 | 0.00909742323246 | 0.5 | XIAP BIRC2 | Small cell lung cancer |
| REAC:R-HSA-5357905 | 0.00966180252737 | 0.5 | XIAP BIRC2 | Regulation of TNFR1 signaling |
| WP:WP5090 | 0.00992155513194 | 0.5 | XIAP DIABLO | Complement system in neuronal development and plasticity |
| KEGG:05145 | 0.0101879335017 | 0.5 | XIAP BIRC2 | Toxoplasmosis |
| KEGG:04668 | 0.011104386562 | 0.5 | XIAP BIRC2 | TNF signaling pathway |
| REAC:R-HSA-109606 | 0.0135329645116 | 0.5 | XIAP DIABLO | Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-5218859 | 0.0140623832262 | 0.5 | XIAP BIRC2 | Regulated Necrosis |
| REAC:R-HSA-75893 | 0.0140623832262 | 0.5 | XIAP BIRC2 | TNF signaling |
| KEGG:04120 | 0.0224124539322 | 0.5 | XIAP BIRC2 | Ubiquitin mediated proteolysis |
| KEGG:04217 | 0.0230797254414 | 0.5 | XIAP BIRC2 | Necroptosis |
| KEGG:04621 | 0.02620193588 | 0.5 | XIAP BIRC2 | NOD-like receptor signaling pathway |
| KEGG:04510 | 0.03673756538 | 0.5 | XIAP BIRC2 | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | XIAP BIRC2 | Focal adhesion |
| CORUM:5529 | 0.049938562206 | 0.25 | BIRC2 | TRAF2-cIAP1/BIRC2 complex |
| CORUM:6292 | 0.049938562206 | 0.25 | XIAP | HAX-1-XIAP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| XIAP | DIABLO | 1.0 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| BIRC2 | DIABLO | 1.0 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BIRC2 | XIAP | 0.995 | 0.14841025641 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LRRN2 | BIRC2 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRN2 | XIAP | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes