hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05774.1
Complex Portal: CPX-20291
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAN2B1 | Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] | 5 | UniProt NCBI |
| PPT2 | Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04142 | 0.00121976041763 | 1.0 | MAN2B1 PPT2 | Lysosome |
| KEGG:00511 | 0.0403663802771 | 0.5 | MAN2B1 | Other glycan degradation |
| HP:0007232 | 0.0499436884913 | 0.5 | MAN2B1 | Spinocerebellar tract disease in lower limbs |
| HP:0034712 | 0.0499436884913 | 0.5 | MAN2B1 | Decreased circulating alpha-mannosidase activity |
| HP:4000190 | 0.0499436884913 | 0.5 | MAN2B1 | Reduced leukocyte alpha-mannosidase activity |
| HP:4000201 | 0.0499436884913 | 0.5 | MAN2B1 | Abnormal circulating alpha mannosidase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAN2B1 | PPT2 | 0.96 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| MAN2B1 | huMAP3_03828.1 huMAP3_05774.1 huMAP3_14233.1 |
| PPT2 | huMAP3_05774.1 huMAP3_06418.1 huMAP3_07947.1 huMAP3_09215.1 huMAP3_09297.1 huMAP3_11275.1 huMAP3_13392.1 huMAP3_14233.1 |