hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05775.1

Complex Portal: CPX-16816

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
CRIPTO	Protein Cripto (Cripto, EGF-CFC family member) (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) (Teratocarcinoma-derived growth factor 1)	5	UniProt NCBI
SKI	Ski oncogene (Proto-oncogene c-Ski)	5	UniProt NCBI
WDR26	WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)	5	UniProt NCBI
HTRA2	Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)	5	UniProt NCBI
SPON1	Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor)	5	UniProt NCBI
GID8	Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)	5	UniProt NCBI
HBP1	HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1)	5	UniProt NCBI
RANBP9	Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7)	5	UniProt NCBI
YPEL5	Protein yippee-like 5	5	UniProt NCBI
ARMC8	Armadillo repeat-containing protein 8	5	UniProt NCBI
RANBP10	Ran-binding protein 10 (RanBP10)	5	UniProt NCBI
GDF15	Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)	5	UniProt NCBI
PRG3	Proteoglycan 3 (Eosinophil major basic protein homolog) (Prepro-major basic protein homolog) (Prepro-MBPH)	5	UniProt NCBI
MAEA	E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)	5	UniProt NCBI
RMND5A	E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A)	5	UniProt NCBI
MKLN1	Muskelin	5	UniProt NCBI
INSL6	Insulin-like peptide INSL6 (Insulin-like peptide 6) (Relaxin/insulin-like factor 1) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain]	3	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:3071	2.62526075648e-14	0.333333333333	RANBP9 RMND5A ARMC8 MKLN1 MAEA	CTLH complex
WP:WP4352	9.03864926349e-14	0.666666666667	RANBP10 WDR26 HTRA2 YPEL5 RANBP9 ARMC8 RMND5A GID8 MKLN1 MAEA	Ciliary landscape
WP:WP5381	4.26850269337e-09	0.466666666667	MAEA WDR26 RMND5A RANBP9 HBP1 ARMC8 MKLN1	Smith Magenis and Potocki Lupski syndrome copy number variation
GO:0000151	6.49074565647e-08	0.6	RANBP10 WDR26 RMND5A YPEL5 RANBP9 ARMC8 GID8 MKLN1 MAEA	ubiquitin ligase complex
CORUM:639	1.6973856751e-07	0.2	GID8 MKLN1 RANBP9	RANBPM-Muskelin-TWA1-HSMpp8 complex
GO:0034657	1.79475545894e-07	0.266666666667	WDR26 RMND5A ARMC8 MAEA	GID complex
GO:1990234	0.000607667975081	0.6	RANBP10 WDR26 RMND5A YPEL5 RANBP9 ARMC8 GID8 MKLN1 MAEA	transferase complex
GO:0140535	0.00100430178281	0.6	RANBP10 WDR26 RMND5A YPEL5 RANBP9 ARMC8 GID8 MKLN1 MAEA	intracellular protein-containing complex
REAC:R-HSA-8851805	0.00821328967792	0.133333333333	RANBP9 RANBP10	MET activates RAS signaling
GO:1902494	0.0139038086596	0.666666666667	RANBP10 WDR26 HTRA2 YPEL5 RANBP9 ARMC8 RMND5A GID8 MKLN1 MAEA	catalytic complex
CORUM:641	0.0498224659463	0.0666666666667	RANBP9	RANBPM-SMP1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
GID8	RANBP10	1.0	0.126	structurally_consistent (P62699)
RMND5A	MAEA	1.0	0.478	structurally_consistent (dimer)
YPEL5	ARMC8	1.0	0.048
RANBP10	ARMC8	1.0	0.152
GID8	MKLN1	1.0	0.064	mutually_exclusive (Q9H871)
RMND5A	RANBP10	1.0	0.196	structurally_consistent (dimer)
RANBP9	RMND5A	1.0	0.272
GID8	RANBP9	1.0	0.264	mutually_exclusive (Q7L5Y9)
MKLN1	ARMC8	1.0	0.024
RMND5A	WDR26	1.0	0.288	structurally_consistent (dimer)
GID8	ARMC8	1.0	0.13
MAEA	ARMC8	1.0	0.072	structurally_consistent (Q9H7D7)
GID8	YPEL5	1.0	0.076	structurally_consistent (dimer)
RMND5A	ARMC8	1.0	0.14
RANBP9	ARMC8	1.0	0.1	structurally_consistent (dimer)
GID8	WDR26	1.0	0.18
RMND5A	MKLN1	1.0	0.096	structurally_consistent (dimer)
GID8	MAEA	1.0	0.144	structurally_consistent (Q9H871) structurally_consistent (dimer)
HTRA2	ARMC8	0.999	0.04	structurally_consistent (dimer)
HTRA2	RMND5A	0.999	0.034	structurally_consistent (dimer)
RMND5A	YPEL5	0.999	0.068	structurally_consistent (dimer)
RANBP9	MAEA	0.999	0.152	mutually_exclusive (Q9H7D7) structurally_consistent (dimer)
GID8	RMND5A	0.999	0.482	structurally_consistent (dimer)
YPEL5	RANBP10	0.999	0.06	structurally_consistent (dimer)
YPEL5	MAEA	0.999	0.066
WDR26	ARMC8	0.999	0.112	structurally_consistent (dimer)
RANBP9	YPEL5	0.999	0.044
RANBP10	MKLN1	0.999	0.1312	mutually_exclusive (Q9H871)
RANBP9	MKLN1	0.998	0.036
MAEA	RANBP10	0.998	0.154	structurally_consistent (Q9H871)
YPEL5	MKLN1	0.998	0.026
RANBP9	RANBP10	0.998	0.048
MAEA	MKLN1	0.998	0.06	structurally_consistent (Q9H871)
RANBP10	WDR26	0.997	0.114
RMND5A	INSL6	0.996
INSL6	WDR26	0.996
PRG3	RANBP10	0.996
SKI	RMND5A	0.996	0.078	structurally_consistent (dimer)
PRG3	WDR26	0.996
PRG3	RMND5A	0.996		structurally_consistent (dimer)
PRG3	ARMC8	0.995	0.168	structurally_consistent (dimer)
INSL6	RANBP10	0.995
PRG3	MAEA	0.995
GID8	HBP1	0.995
INSL6	MAEA	0.995
INSL6	MKLN1	0.994
INSL6	ARMC8	0.994
RANBP9	PRG3	0.993
HTRA2	GID8	0.993	0.066
GID8	PRG3	0.993		structurally_consistent (Q9H871)
PRG3	MKLN1	0.993
HBP1	RMND5A	0.993
CRIPTO	WDR26	0.993
HBP1	ARMC8	0.992
CRIPTO	RMND5A	0.99
INSL6	YPEL5	0.989
CRIPTO	ARMC8	0.989		mutually_exclusive (Q8IVV7) structurally_consistent (dimer)
RANBP9	INSL6	0.989
YPEL5	WDR26	0.989	0.192	structurally_consistent (dimer)
CRIPTO	RANBP10	0.989
SKI	ARMC8	0.988	0.102	structurally_consistent (dimer)
SKI	GID8	0.988	0.106
SPON1	YPEL5	0.988	0.022
CRIPTO	MKLN1	0.987
CRIPTO	GID8	0.986
HTRA2	RANBP10	0.985	0.05
CRIPTO	RANBP9	0.985		mutually_exclusive (Q8IUR7)
CRIPTO	MAEA	0.985
CRIPTO	YPEL5	0.984
GDF15	MAEA	0.984	0.01
MAEA	WDR26	0.983	0.31	structurally_consistent (dimer)
GDF15	MKLN1	0.982	0.026
RANBP9	GDF15	0.979	0.044
RANBP9	WDR26	0.979	0.264	structurally_consistent (dimer)
SPON1	RANBP9	0.979	0.054
HTRA2	MAEA	0.979	0.024	mutually_exclusive (Q9H871)
HTRA2	YPEL5	0.978	0.046
SPON1	MKLN1	0.977	0.082
MKLN1	WDR26	0.977	0.024	mutually_exclusive (Q9H871)
HTRA2	SKI	0.976	0.116
GID8	INSL6	0.975
GDF15	WDR26	0.975	0.02	structurally_consistent (P62699)
GDF15	ARMC8	0.972	0.092
SPON1	GID8	0.972	0.05
GDF15	YPEL5	0.969	0.062	structurally_consistent (dimer)
GID8	GDF15	0.969	0.036
HTRA2	MKLN1	0.967	0.028
HTRA2	RANBP9	0.967	0.05
GDF15	RMND5A	0.967	0.052
SPON1	RMND5A	0.964	0.064
GDF15	RANBP10	0.96	0.016
SPON1	WDR26	0.952	0.052
PRG3	YPEL5	0.949
HTRA2	HBP1	0.948
HTRA2	GDF15	0.947	0.056
SKI	YPEL5	0.945	0.104
HTRA2	WDR26	0.939	0.06
SPON1	MAEA	0.934	0.044
HBP1	WDR26	0.911
HBP1	MAEA	0.905
SKI	MKLN1	0.905	0.052
SPON1	ARMC8	0.904	0.06	structurally_consistent (dimer)
HBP1	RANBP10	0.902
HBP1	MKLN1	0.887
SKI	WDR26	0.885	0.132
SKI	MAEA	0.882	0.108	mutually_exclusive (Q9H871)
RANBP9	HBP1	0.87
HTRA2	INSL6	0.863
HBP1	YPEL5	0.859
GDF15	PRG3	0.856
SKI	RANBP10	0.849	0.18
SKI	RANBP9	0.832	0.096	mutually_exclusive (Q8IUR7)
SKI	HBP1	0.777
SPON1	RANBP10	0.758	0.054
HBP1	GDF15	0.663
CRIPTO	HTRA2	0.354
SKI	GDF15	0.305	0.086
HTRA2	PRG3	0.294	0.052	mutually_exclusive (Q8IUR7)
SPON1	GDF15	0.038	0.056
CRIPTO	GDF15	0.027

Related Complexes

Genename	Complexes
CRIPTO	huMAP3_02074.1 huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_13363.1
SKI	huMAP3_03100.1 huMAP3_05458.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12636.1 huMAP3_12700.1 huMAP3_13984.1
WDR26	huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1
HTRA2	huMAP3_02517.1 huMAP3_03100.1 huMAP3_03925.1 huMAP3_05775.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_08787.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09818.1 huMAP3_09978.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1
SPON1	huMAP3_00307.1 huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_14022.1 huMAP3_15190.1
GID8	huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_11676.1 huMAP3_12700.1
HBP1	huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1
RANBP9	huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1
YPEL5	huMAP3_04239.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_14022.1
ARMC8	huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1
RANBP10	huMAP3_04239.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1
GDF15	huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1
PRG3	huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1
MAEA	huMAP3_04239.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1
RMND5A	huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_15190.1
MKLN1	huMAP3_04239.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1
INSL6	huMAP3_03100.1 huMAP3_05775.1 huMAP3_08787.1 huMAP3_09818.1 huMAP3_10711.1 huMAP3_12700.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05775.1

Complex Portal: CPX-16816