hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05779.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C15orf39 | Uncharacterized protein C15orf39 | 3 | UniProt NCBI |
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | 5 | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | 5 | UniProt NCBI |
| MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 3.07520988333e-05 | 0.5 | POLA2 POLA1 | DNA polymerase alpha-primase complex |
| CORUM:1003 | 0.000143457417375 | 0.5 | POLA2 POLA1 | RC complex (Replication competent complex) |
| CORUM:1107 | 0.000184428417548 | 0.5 | POLA2 POLA1 | DNA synthesome core complex |
| CORUM:1098 | 0.000230514481314 | 0.5 | POLA2 POLA1 | DNA synthesome complex (13 subunits) |
| REAC:R-HSA-68952 | 0.000286914834749 | 0.5 | POLA2 POLA1 | DNA replication initiation |
| CORUM:1108 | 0.00039944903428 | 0.5 | POLA2 POLA1 | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 0.000465981333253 | 0.5 | POLA2 POLA1 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 0.000465981333253 | 0.5 | POLA2 POLA1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-174430 | 0.000798898068561 | 0.5 | POLA2 POLA1 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-113501 | 0.000798898068561 | 0.5 | POLA2 POLA1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-69091 | 0.000931962666506 | 0.5 | POLA2 POLA1 | Polymerase switching |
| REAC:R-HSA-69109 | 0.000931962666506 | 0.5 | POLA2 POLA1 | Leading Strand Synthesis |
| REAC:R-HSA-69166 | 0.000931962666506 | 0.5 | POLA2 POLA1 | Removal of the Flap Intermediate |
| REAC:R-HSA-69183 | 0.00107524337392 | 0.5 | POLA2 POLA1 | Processive synthesis on the lagging strand |
| KEGG:03030 | 0.00157527945983 | 0.5 | POLA2 POLA1 | DNA replication |
| REAC:R-HSA-69186 | 0.00194479046925 | 0.5 | POLA2 POLA1 | Lagging Strand Synthesis |
| WP:WP466 | 0.002190823719 | 0.5 | POLA2 POLA1 | DNA replication |
| REAC:R-HSA-113510 | 0.00236402400204 | 0.5 | POLA2 POLA1 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-174411 | 0.00332479301982 | 0.5 | POLA2 POLA1 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69190 | 0.00507136546841 | 0.5 | POLA2 POLA1 | DNA strand elongation |
| REAC:R-HSA-68962 | 0.00539805716719 | 0.5 | POLA2 POLA1 | Activation of the pre-replicative complex |
| REAC:R-HSA-174417 | 0.00573491177379 | 0.5 | POLA2 POLA1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 0.0130136556072 | 0.5 | POLA2 POLA1 | Extension of Telomeres |
| REAC:R-HSA-9710421 | 0.0186613511621 | 0.5 | POLA2 POLA1 | Defective pyroptosis |
| GO:0006269 | 0.0280843539964 | 0.5 | POLA2 POLA1 | DNA replication, synthesis of RNA primer |
| GO:0005658 | 0.0280843539964 | 0.5 | POLA2 POLA1 | alpha DNA polymerase:primase complex |
| REAC:R-HSA-69278 | 0.0329329593357 | 0.75 | POLA2 POLA1 MAD2L1 | Cell Cycle, Mitotic |
| REAC:R-HSA-9645723 | 0.041644107744 | 0.5 | POLA2 POLA1 | Diseases of programmed cell death |
| CORUM:2718 | 0.049938562206 | 0.25 | MAD2L1 | MAD2-CDC20 complex |
| CORUM:1814 | 0.049938562206 | 0.25 | MAD2L1 | MAD1L1-MAD2L1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAD2L1 | POLA1 | 0.999 | 0.186 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| MAD2L1 | C15orf39 | 0.996 | 0.084 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| MAD2L1 | POLA2 | 0.994 | 0.458 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
| POLA1 | POLA2 | 0.979 | 0.84 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| C15orf39 | POLA2 | 0.971 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| POLA1 | C15orf39 | 0.928 | 0.09 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes