hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05786.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | 5 | UniProt NCBI |
| WWTR1 | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | 5 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | 5 | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | 5 | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | 5 | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 1.11211677466e-14 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | RUNX3 regulates YAP1-mediated transcription |
| REAC:R-HSA-2032785 | 1.57249195303e-13 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| WP:WP4537 | 9.00597826502e-13 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Hippo YAP signaling |
| KEGG:04392 | 3.6745301761e-12 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Hippo signaling pathway - multiple species |
| GO:0035329 | 1.93984014703e-11 | 1.0 | WWTR1 AMOTL2 TEAD1 TEAD2 TEAD4 YAP1 | hippo signaling |
| WP:WP4534 | 5.090214866e-11 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| WP:WP3967 | 1.02925563038e-09 | 0.666666666667 | TEAD2 TEAD4 YAP1 TEAD1 | miR 509 3p alteration of YAP1 ECM axis |
| WP:WP4540 | 2.10567096515e-09 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Hippo signaling regulation pathways |
| WP:WP4541 | 4.71329858835e-09 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Hippo Merlin signaling dysregulation |
| REAC:R-HSA-8878159 | 7.74449507376e-09 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Transcriptional regulation by RUNX3 |
| WP:WP4542 | 1.34126591933e-08 | 0.666666666667 | TEAD2 TEAD4 YAP1 TEAD1 | Leukocyte intrinsic Hippo pathway functions |
| KEGG:04390 | 2.86185774302e-08 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Hippo signaling pathway |
| REAC:R-HSA-9796292 | 5.93134254527e-07 | 0.5 | TEAD2 TEAD4 YAP1 | Formation of axial mesoderm |
| GO:0140552 | 1.92240082153e-06 | 0.5 | TEAD2 TEAD1 YAP1 | TEAD-YAP complex |
| WP:WP4533 | 2.24542123067e-06 | 0.5 | TEAD2 TEAD4 TEAD1 | Transcription co factors SKI and SKIL protein partners |
| WP:WP5087 | 4.38527334811e-06 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Pleural mesothelioma |
| REAC:R-HSA-2028269 | 6.83169380613e-06 | 0.5 | WWTR1 AMOTL2 YAP1 | Signaling by Hippo |
| REAC:R-HSA-9619665 | 9.37394499108e-06 | 0.5 | WWTR1 TEAD1 YAP1 | EGR2 and SOX10-mediated initiation of Schwann cell myelination |
| CORUM:6651 | 1.70876175213e-05 | 0.333333333333 | WWTR1 YAP1 | WWTR1-YAP1 complex |
| REAC:R-HSA-9758941 | 5.46286536752e-05 | 0.5 | TEAD2 TEAD4 YAP1 | Gastrulation |
| REAC:R-HSA-1266738 | 0.000707119981671 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Developmental Biology |
| WP:WP2857 | 0.000902045467948 | 0.5 | TEAD2 TEAD1 YAP1 | Mesodermal commitment pathway |
| REAC:R-HSA-212436 | 0.00174662531744 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.00300615431734 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | RNA Polymerase II Transcription |
| REAC:R-HSA-8940973 | 0.00488968644054 | 0.333333333333 | WWTR1 YAP1 | RUNX2 regulates osteoblast differentiation |
| REAC:R-HSA-74160 | 0.00558415609329 | 0.833333333333 | YAP1 WWTR1 TEAD4 TEAD1 TEAD2 | Gene expression (Transcription) |
| REAC:R-HSA-8941326 | 0.00771351163082 | 0.333333333333 | WWTR1 YAP1 | RUNX2 regulates bone development |
| CORUM:6652 | 0.0499436884912 | 0.166666666667 | WWTR1 | WWTR1 homodimer |
| CORUM:7062 | 0.0499436884912 | 0.166666666667 | WWTR1 | NFAT5-WWTR1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TEAD2 | TEAD1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WWTR1 | TEAD1 | 1.0 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| WWTR1 | TEAD4 | 0.999 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| WWTR1 | TEAD2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD4 | TEAD1 | 0.999 | 0.38 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TEAD2 | YAP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD2 | TEAD4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AMOTL2 | YAP1 | 0.997 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| YAP1 | TEAD4 | 0.994 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| WWTR1 | AMOTL2 | 0.975 | 0.104 | hein_WMM bioplex3_WMM WMM_only |
| WWTR1 | YAP1 | 0.974 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| AMOTL2 | TEAD1 | 0.956 | 0.126 | hein_WMM bioplex3_WMM WMM_only |
| YAP1 | TEAD1 | 0.923 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| AMOTL2 | TEAD4 | 0.248 | 0.068 | hein_WMM WMM_only |
Related Complexes