hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05805.1

Complex Portal: CPX-25276

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
ATP6V1F	V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F)	5	UniProt NCBI
ATP6V1B2	V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)	5	UniProt NCBI
GPRC5A	Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)	5	UniProt NCBI
CYBRD1	Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3)	5	UniProt NCBI
ATP6V1G1	V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16)	5	UniProt NCBI
TCIRG1	V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3)	5	UniProt NCBI
ATP6AP2	Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]	5	UniProt NCBI
ATP6V1D	V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)	5	UniProt NCBI
ATP6V1B1	V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1)	5	UniProt NCBI
TMEM199	Transmembrane protein 199	5	UniProt NCBI
ATP6V0A1	V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)	5	UniProt NCBI
ATP6V1E1	V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)	5	UniProt NCBI
ATP6V1C1	V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)	5	UniProt NCBI
VMA21	Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)	5	UniProt NCBI
CCDC115	Coiled-coil domain-containing protein 115	5	UniProt NCBI
ATP6V0D1	V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1)	5	UniProt NCBI
ATP6V1G2	V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2)	5	UniProt NCBI
ATP6V0D2	V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2)	5	UniProt NCBI
ATP6V1A	V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)	5	UniProt NCBI
ATP6V0C	V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)	5	UniProt NCBI
ATP6V0A2	V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016471	8.501617518e-45	0.85	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V1G2	vacuolar proton-transporting V-type ATPase complex
GO:0033176	3.25832064655e-44	0.85	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V1G2	proton-transporting V-type ATPase complex
GO:0016469	2.20635965855e-37	0.85	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V1G2	proton-transporting two-sector ATPase complex
KEGG:04966	8.17373225645e-36	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Collecting duct acid secretion
REAC:R-HSA-77387	2.0770574661e-33	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Insulin receptor recycling
REAC:R-HSA-917977	2.0770574661e-33	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Transferrin endocytosis and recycling
REAC:R-HSA-1222556	1.37141542204e-32	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	ROS and RNS production in phagocytes
REAC:R-HSA-917937	9.47267145015e-32	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 ATP6V1G2 TCIRG1 ATP6V1E1 ATP6V0D1	Iron uptake and transport
KEGG:05110	1.65504363254e-30	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Vibrio cholerae infection
KEGG:04721	1.7104861961e-28	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Synaptic vesicle cycle
KEGG:05120	3.68252074527e-28	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Epithelial cell signaling in Helicobacter pylori infection
GO:0007035	6.50215101176e-28	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	vacuolar acidification
GO:1904949	8.63884703349e-28	0.85	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V1G2	ATPase complex
KEGG:05323	1.21148312815e-27	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Rheumatoid arthritis
REAC:R-HSA-74752	1.48603292767e-27	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Signaling by Insulin receptor
GO:0051452	3.04219407193e-25	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	intracellular pH reduction
KEGG:00190	8.233343148e-24	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Oxidative phosphorylation
KEGG:04145	2.62621685853e-23	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Phagosome
GO:0005774	4.39184551963e-23	0.9	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 ATP6V1G2 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V0D1	vacuolar membrane
REAC:R-HSA-9639288	5.17922663405e-23	0.6	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V1F ATP6V1G2 TCIRG1 ATP6V0D2	Amino acids regulate mTORC1
REAC:R-HSA-983712	5.42761402501e-23	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Ion channel transport
GO:0051453	8.84552762267e-23	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	regulation of intracellular pH
GO:0030641	1.4210850834e-22	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	regulation of cellular pH
GO:0006885	2.80497208146e-22	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	regulation of pH
GO:0005773	8.66862396556e-21	0.95	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 VMA21 ATP6V0A1 ATP6V1G2 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V0D1	vacuole
GO:1902600	1.36990054405e-20	0.6	ATP6V1D ATP6V1A ATP6V0D1 ATP6V0C ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2	proton transmembrane transport
KEGG:05165	2.71932865274e-18	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Human papillomavirus infection
GO:0007042	9.21388222432e-18	0.45	ATP6V1D ATP6V0C ATP6V1A TMEM199 ATP6V1F CCDC115 ATP6V0A1 TCIRG1 ATP6AP2	lysosomal lumen acidification
GO:0000221	2.0124792221e-17	0.4	ATP6V1D ATP6V1G1 ATP6V1B2 ATP6V1F ATP6V1E1 ATP6V1C1 ATP6V1A ATP6V1G2	vacuolar proton-transporting V-type ATPase, V1 domain
GO:0033180	2.0124792221e-17	0.4	ATP6V1D ATP6V1G1 ATP6V1B2 ATP6V1F ATP6V1E1 ATP6V1C1 ATP6V1A ATP6V1G2	proton-transporting V-type ATPase, V1 domain
GO:0030003	3.78970223398e-17	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2 ATP6V0D1	intracellular monoatomic cation homeostasis
REAC:R-HSA-9711097	4.07152634056e-17	0.6	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V1F ATP6V1G2 TCIRG1 ATP6V0D2	Cellular response to starvation
GO:0006873	4.39122073026e-17	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2 ATP6V0D1	intracellular monoatomic ion homeostasis
GO:0098852	8.57064426761e-17	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	lytic vacuole membrane
GO:0005765	8.57064426761e-17	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	lysosomal membrane
GO:0035751	1.29970208895e-16	0.45	ATP6V1D ATP6V0C ATP6V1A TMEM199 ATP6V1F CCDC115 ATP6V0A1 TCIRG1 ATP6AP2	regulation of lysosomal lumen pH
GO:0055080	1.69929172454e-16	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2 ATP6V0D1	monoatomic cation homeostasis
GO:0050801	2.21523235063e-16	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2 ATP6V0D1	monoatomic ion homeostasis
REAC:R-HSA-382551	9.01255176297e-16	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 ATP6V1G2 TCIRG1 ATP6V1E1 ATP6V0D1	Transport of small molecules
GO:0016241	1.26377517045e-15	0.6	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V0A2 ATP6V1G2 ATP6V0A1 ATP6V0D2	regulation of macroautophagy
GO:0055082	1.77312231209e-15	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2 ATP6V0D1	intracellular chemical homeostasis
GO:0033178	2.95208141512e-15	0.4	ATP6V1D ATP6V1G1 ATP6V1B2 ATP6V1F ATP6V1E1 ATP6V1C1 ATP6V1A ATP6V1G2	proton-transporting two-sector ATPase complex, catalytic domain
REAC:R-HSA-9006934	3.23451178648e-15	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Signaling by Receptor Tyrosine Kinases
GO:0005764	5.32376817601e-15	0.8	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 VMA21 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	lysosome
GO:0000323	5.32376817601e-15	0.8	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 VMA21 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	lytic vacuole
WP:WP4917	1.8152829924e-14	0.4	ATP6V1D ATP6V1G1 ATP6V0D2 ATP6V1F ATP6V1C1 ATP6V1E1 ATP6V0C ATP6V1A	Proximal tubule transport
GO:0019725	2.5636784712e-14	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2 ATP6V0D1	cellular homeostasis
GO:0016236	8.74437235638e-14	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1E1 ATP6V1B2 ATP6V0A2 TCIRG1 ATP6V0A1 ATP6V1G2	macroautophagy
GO:0042625	1.0836278518e-13	0.35	ATP6V0C ATP6V1B2 ATP6V1F ATP6V1C1 ATP6V1E1 ATP6V1A TCIRG1	ATPase-coupled ion transmembrane transporter activity
GO:0098796	1.67379525028e-13	0.85	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V1G2	membrane protein complex
GO:0048878	3.67135609659e-13	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2 ATP6V0D1	chemical homeostasis
REAC:R-HSA-168249	1.83256322767e-12	0.75	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V1G2	Innate Immune System
GO:0098588	5.86563195998e-12	0.9	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 ATP6V1G2 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V0D1	bounding membrane of organelle
GO:0010506	1.83922009813e-11	0.6	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V0A2 ATP6V1G2 ATP6V0A1 ATP6V0D2	regulation of autophagy
GO:0007040	2.80043385984e-11	0.45	ATP6V1D ATP6V0C ATP6V1A TMEM199 ATP6V1F CCDC115 ATP6V0A1 TCIRG1 ATP6AP2	lysosome organization
GO:0080171	2.80043385984e-11	0.45	ATP6V1D ATP6V0C ATP6V1A TMEM199 ATP6V1F CCDC115 ATP6V0A1 TCIRG1 ATP6AP2	lytic vacuole organization
GO:0048388	3.00006608103e-11	0.3	ATP6V1D ATP6V0C ATP6V1F ATP6V1A ATP6V0A1 ATP6AP2	endosomal lumen acidification
GO:0061795	3.00006608103e-11	0.3	ATP6V1D ATP6V0C ATP6V1F ATP6V0A2 ATP6V1A ATP6AP2	Golgi lumen acidification
GO:0061919	5.50497474033e-11	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1E1 ATP6V1B2 ATP6V0A2 TCIRG1 ATP6V0A1 ATP6V1G2	process utilizing autophagic mechanism
GO:0006914	5.50497474033e-11	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1E1 ATP6V1B2 ATP6V0A2 TCIRG1 ATP6V0A1 ATP6V1G2	autophagy
GO:0046961	6.59472301589e-11	0.3	ATP6V0C ATP6V1C1 ATP6V1B2 ATP6V1A TCIRG1 ATP6V1E1	proton-transporting ATPase activity, rotational mechanism
GO:0036295	6.59472301589e-11	0.3	ATP6V0D1 ATP6V1G1 TMEM199 CCDC115 ATP6V0A2 ATP6V1A	cellular response to increased oxygen levels
GO:0044769	6.59472301589e-11	0.3	ATP6V0C ATP6V1C1 ATP6V1B2 ATP6V1A TCIRG1 ATP6V1E1	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
GO:0036296	1.31786097533e-10	0.3	ATP6V0D1 ATP6V1G1 TMEM199 CCDC115 ATP6V0A2 ATP6V1A	response to increased oxygen levels
GO:0006812	5.76727954243e-10	0.65	CYBRD1 ATP6V1A ATP6V1D ATP6V0C ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	monoatomic cation transport
KEGG:04150	6.22185236575e-10	0.4	ATP6V1D ATP6V1G1 ATP6V1B2 ATP6V1F ATP6V1E1 ATP6V1C1 ATP6V1A ATP6V1G2	mTOR signaling pathway
GO:0042592	7.52770730706e-10	0.75	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2 ATP6V0D1	homeostatic process
GO:1902494	8.23473279992e-10	0.85	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V1G2	catalytic complex
GO:0098662	9.83023812741e-10	0.6	ATP6V1D ATP6V1A ATP6V0D1 ATP6V0C ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2	inorganic cation transmembrane transport
GO:0098655	1.10459589959e-09	0.6	ATP6V1D ATP6V1A ATP6V0D1 ATP6V0C ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2	monoatomic cation transmembrane transport
GO:0031090	1.77591263781e-09	0.95	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 VMA21 ATP6V0A1 ATP6V1G2 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V0D1	organelle membrane
KEGG:01100	2.44900428963e-09	0.7	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Metabolic pathways
GO:0098660	2.62575342472e-09	0.6	ATP6V1D ATP6V1A ATP6V0D1 ATP6V0C ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2	inorganic ion transmembrane transport
GO:0006811	3.83503225645e-09	0.65	CYBRD1 ATP6V1A ATP6V1D ATP6V0C ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	monoatomic ion transport
REAC:R-HSA-2262752	5.33272012943e-09	0.6	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V1F ATP6V1G2 TCIRG1 ATP6V0D2	Cellular responses to stress
GO:0034220	5.87563019621e-09	0.6	ATP6V1D ATP6V1A ATP6V0D1 ATP6V0C ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2	monoatomic ion transmembrane transport
REAC:R-HSA-8953897	5.96953804965e-09	0.6	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V1F ATP6V1G2 TCIRG1 ATP6V0D2	Cellular responses to stimuli
GO:0006879	1.536599579e-08	0.35	CYBRD1 ATP6V1G1 ATP6V0D1 TMEM199 CCDC115 ATP6V0A2 ATP6V1A	intracellular iron ion homeostasis
REAC:R-HSA-168256	2.22297696846e-08	0.75	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V1G2	Immune System
GO:0031329	2.70063715419e-08	0.6	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V0A2 ATP6V1G2 ATP6V0A1 ATP6V0D2	regulation of cellular catabolic process
HP:0012345	4.04562646177e-08	0.3	TMEM199 CCDC115 ATP6V1E1 ATP6V0A2 ATP6V1A ATP6AP2	Abnormal glycosylation
GO:0007033	4.19286242308e-08	0.45	ATP6V1D ATP6V0C ATP6V1A TMEM199 ATP6V1F CCDC115 ATP6V0A1 TCIRG1 ATP6AP2	vacuole organization
CORUM:6888	9.23346914599e-08	0.2	ATP6V0D1 ATP6V0C ATP6V1B2 ATP6V1A	v-ATPase-Ragulator-AXIN/LKB1-AMPK complex
GO:0033179	1.27484697239e-07	0.2	ATP6V0A1 ATP6V0C ATP6AP2 ATP6V0D1	proton-transporting V-type ATPase, V0 domain
GO:0000220	1.27484697239e-07	0.2	ATP6V0A1 ATP6V0C ATP6AP2 ATP6V0D1	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0042626	1.56761245204e-07	0.35	ATP6V0C ATP6V1B2 ATP6V1F ATP6V1C1 ATP6V1E1 ATP6V1A TCIRG1	ATPase-coupled transmembrane transporter activity
GO:0015399	1.60049743807e-07	0.4	CYBRD1 ATP6V0C ATP6V1B2 ATP6V1F ATP6V1E1 ATP6V1C1 ATP6V1A TCIRG1	primary active transmembrane transporter activity
REAC:R-HSA-162582	3.05297358575e-07	0.75	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V1G2	Signal Transduction
GO:0010008	3.24232565839e-07	0.5	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 ATP6V0D2 ATP6V1F ATP6V0A2 TCIRG1 ATP6V0A1 ATP6AP2	endosome membrane
GO:0019829	3.24826414943e-07	0.3	ATP6V0C ATP6V1C1 ATP6V1B2 ATP6V1A TCIRG1 ATP6V1E1	ATPase-coupled monoatomic cation transmembrane transporter activity
KEGG:04142	6.62402687575e-07	0.3	ATP6V0A1 ATP6V0D1 ATP6V0C ATP6V0A2 ATP6V0D2 TCIRG1	Lysosome
GO:0030670	7.29948763009e-07	0.3	ATP6V0A1 ATP6V0D1 ATP6V0C ATP6V0A2 ATP6V0D2 TCIRG1	phagocytic vesicle membrane
GO:0015078	1.12606466791e-06	0.35	ATP6V0C ATP6V1B2 ATP6V1F ATP6V1C1 ATP6V1E1 ATP6V1A TCIRG1	proton transmembrane transporter activity
GO:0055085	1.79326775559e-06	0.6	ATP6V1D ATP6V1A ATP6V0D1 ATP6V0C ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2	transmembrane transport
KEGG:05152	1.8541089494e-06	0.3	ATP6V0A1 ATP6V0D1 ATP6V0C ATP6V0A2 ATP6V0D2 TCIRG1	Tuberculosis
GO:0031982	2.18247167983e-06	0.9	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 GPRC5A ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V0D1	vesicle
GO:0009894	2.21307551988e-06	0.6	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V1B2 ATP6V1C1 ATP6V1E1 ATP6V0A2 ATP6V1G2 ATP6V0A1 ATP6V0D2	regulation of catabolic process
HP:0025244	2.6089725435e-06	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Subretinal pigment epithelium hemorrhage
HP:0012347	2.73934268006e-06	0.25	TMEM199 ATP6V0A2 ATP6V1A ATP6AP2 ATP6V1E1	Abnormal protein N-linked glycosylation
HP:0012346	3.09712705231e-06	0.25	TMEM199 ATP6V0A2 ATP6V1A ATP6AP2 ATP6V1E1	Abnormal protein glycosylation
HP:0007457	1.04267841242e-05	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Prominent veins on trunk
GO:0044248	1.34588359119e-05	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 ATP6V0D2 ATP6V1C1 ATP6V1E1 ATP6V1B2 ATP6V0A2 TCIRG1 ATP6V0A1 ATP6V1G2	cellular catabolic process
GO:0009056	1.61663939598e-05	0.75	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 TMEM199 ATP6V1C1 ATP6V1B2 ATP6V1E1 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6V1G2	catabolic process
GO:0005768	1.82537157352e-05	0.55	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 ATP6V0D2 ATP6V1E1 ATP6V1F ATP6V0A2 TCIRG1 ATP6V0A1 ATP6AP2	endosome
HP:0032245	1.92405547369e-05	0.3	TMEM199 CCDC115 ATP6V1E1 ATP6V0A2 ATP6V1A ATP6AP2	Abnormal metabolism
GO:0030659	3.36837841853e-05	0.55	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 TMEM199 ATP6V1F ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	cytoplasmic vesicle membrane
GO:0012506	3.98635516622e-05	0.55	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 TMEM199 ATP6V1F ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	vesicle membrane
GO:0007032	4.37319895275e-05	0.3	ATP6V1D ATP6V0C ATP6V1F ATP6V1A ATP6V0A1 ATP6AP2	endosome organization
HP:0025082	5.20429797495e-05	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Abnormal cutaneous elastic fiber morphology
HP:0025167	5.20429797495e-05	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Fragmented elastic fibers in the dermis
GO:0045335	5.87396274679e-05	0.3	ATP6V0A1 ATP6V0D1 ATP6V0C ATP6V0A2 ATP6V0D2 TCIRG1	phagocytic vesicle
GO:0033177	6.26639816222e-05	0.2	ATP6V0A1 ATP6V0C ATP6AP2 ATP6V0D1	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0022804	7.14350822267e-05	0.4	CYBRD1 ATP6V0C ATP6V1B2 ATP6V1F ATP6V1E1 ATP6V1C1 ATP6V1A TCIRG1	active transmembrane transporter activity
GO:0071453	7.26053128429e-05	0.3	ATP6V0D1 ATP6V1G1 TMEM199 CCDC115 ATP6V0A2 ATP6V1A	cellular response to oxygen levels
HP:0007552	9.09957458529e-05	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Abnormal subcutaneous fat tissue distribution
HP:0025201	0.000145466154827	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Abnormal circulating apolipoprotein concentration
GO:0070062	0.000207783725287	0.7	CYBRD1 ATP6V0C ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 GPRC5A ATP6V1A ATP6V0A1 ATP6V1E1 ATP6AP2 ATP6V0D1	extracellular exosome
HP:0006891	0.000218008841388	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Thick cerebral cortex
GO:1903561	0.000234858617	0.7	CYBRD1 ATP6V0C ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 GPRC5A ATP6V1A ATP6V0A1 ATP6V1E1 ATP6AP2 ATP6V0D1	extracellular vesicle
GO:0043230	0.000236547992009	0.7	CYBRD1 ATP6V0C ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 GPRC5A ATP6V1A ATP6V0A1 ATP6V1E1 ATP6AP2 ATP6V0D1	extracellular organelle
GO:0065010	0.000236547992009	0.7	CYBRD1 ATP6V0C ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 GPRC5A ATP6V1A ATP6V0A1 ATP6V1E1 ATP6AP2 ATP6V0D1	extracellular membrane-bounded organelle
HP:0003160	0.000268781780298	0.2	ATP6V1A ATP6V0A2 ATP6AP2 ATP6V1E1	Abnormal isoelectric focusing of serum transferrin
HPA:0271153	0.000292007913136	0.2	ATP6V0A1 ATP6V1D ATP6V1F ATP6V1B2	kidney; proximal tubules (microvilli)[High]
GO:0016020	0.000343584922633	1.0	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 VMA21 GPRC5A ATP6V0A1 ATP6V1G2 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V0D1	membrane
GO:0065008	0.000804078909316	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 CCDC115 TMEM199 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	regulation of biological quality
GO:0031410	0.000885336832759	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 CCDC115 TMEM199 ATP6V1F ATP6V1E1 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	cytoplasmic vesicle
GO:0097708	0.000905121247538	0.65	ATP6V1D ATP6V0C ATP6V1A ATP6V0D1 CCDC115 TMEM199 ATP6V1F ATP6V1E1 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V0D2 ATP6AP2	intracellular vesicle
GO:0051117	0.00101194348974	0.25	TCIRG1 ATP6V0A2 ATP6V1E1 ATP6V1G1 ATP6V0A1	ATPase binding
HP:0005272	0.00117471246897	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Prominent nasolabial fold
GO:0070482	0.00131093372743	0.3	ATP6V0D1 ATP6V1G1 TMEM199 CCDC115 ATP6V0A2 ATP6V1A	response to oxygen levels
GO:0030666	0.00154818097275	0.3	ATP6V0A1 ATP6V0D1 ATP6V0C ATP6V0A2 ATP6V0D2 TCIRG1	endocytic vesicle membrane
HP:0005289	0.00175255191966	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Abnormality of the nasolabial region
HP:0100874	0.00175255191966	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Thick hair
GO:0022853	0.00189359035303	0.3	ATP6V0C ATP6V1C1 ATP6V1B2 ATP6V1A TCIRG1 ATP6V1E1	active monoatomic ion transmembrane transporter activity
HP:0002361	0.00210122732653	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Psychomotor deterioration
HPA:0271152	0.00217051269867	0.2	ATP6V0A1 ATP6V1D ATP6V1F ATP6V1B2	kidney; proximal tubules (microvilli)[>=Medium]
HPA:0090992	0.00259202698815	0.2	ATP6V1G2 ATP6V0A1 ATP6V1F ATP6V1B2	cerebellum; molecular layer - neuropil[>=Medium]
HPA:0271151	0.00268307563993	0.2	ATP6V0A1 ATP6V1D ATP6V1F ATP6V1B2	kidney; proximal tubules (microvilli)[>=Low]
GO:0005886	0.00305779651042	0.8	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 GPRC5A ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	plasma membrane
GO:0098771	0.00366896777418	0.35	CYBRD1 ATP6V1G1 ATP6V0D1 TMEM199 CCDC115 ATP6V0A2 ATP6V1A	inorganic ion homeostasis
HP:0200141	0.00634893468462	0.1	ATP6V0A2 ATP6V1B2	Small, conical teeth
HP:0000573	0.00747303349126	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Retinal hemorrhage
HP:0031803	0.00747303349126	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Fundus hemorrhage
HP:0005989	0.00747303349126	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Redundant neck skin
HPA:0090942	0.00884687671664	0.25	ATP6V1G2 ATP6V0A1 ATP6V1G1 ATP6V1F ATP6V1B2	cerebellum; Purkinje cells - cytoplasm/membrane[>=Medium]
HP:0010647	0.00904202378942	0.25	ATP6V1A ATP6V0A2 ATP6V1E1 ATP6V1B2 ATP6AP2	Abnormal elasticity of skin
HP:0001015	0.00931926013385	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Prominent superficial veins
GO:0022890	0.010356296776	0.35	ATP6V0C ATP6V1B2 ATP6V1F ATP6V1C1 ATP6V1E1 ATP6V1A TCIRG1	inorganic cation transmembrane transporter activity
GO:0032991	0.0104451723881	0.9	ATP6V1D ATP6V0C ATP6V1A ATP6V1G1 ATP6V0D1 CCDC115 TMEM199 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 GPRC5A ATP6V0A1 TCIRG1 ATP6V1E1 ATP6V0D2 ATP6AP2 ATP6V1G2	protein-containing complex
HP:0001476	0.0114441733377	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Delayed closure of the anterior fontanelle
HP:0010989	0.0114441733377	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Abnormality of the intrinsic pathway
HP:0007394	0.0126170356344	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Prominent superficial blood vessels
GO:0071944	0.0130369889193	0.8	CYBRD1 ATP6V0C ATP6V1A ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 GPRC5A ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	cell periphery
HP:0007392	0.013866630347	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Excessive wrinkled skin
GO:0005615	0.0154989706482	0.7	CYBRD1 ATP6V0C ATP6V1G1 ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 GPRC5A ATP6V1A ATP6V0A1 ATP6V1E1 ATP6AP2 ATP6V0D1	extracellular space
GO:0008324	0.0183715036395	0.35	ATP6V0C ATP6V1B2 ATP6V1F ATP6V1C1 ATP6V1E1 ATP6V1A TCIRG1	monoatomic cation transmembrane transporter activity
HP:0002761	0.0196789220555	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Generalized joint hypermobility
HP:0000973	0.0196996443101	0.2	ATP6V1A ATP6V0A2 ATP6AP2 ATP6V1E1	Cutis laxa
HPA:0090941	0.0218106982112	0.25	ATP6V1G2 ATP6V0A1 ATP6V1G1 ATP6V1F ATP6V1B2	cerebellum; Purkinje cells - cytoplasm/membrane[>=Low]
GO:0101003	0.0218974502789	0.2	TCIRG1 ATP6V0C ATP6AP2 ATP6V0A1	ficolin-1-rich granule membrane
HP:0001305	0.0264534503687	0.2	ATP6V1A ATP6V0A2 ATP6V1B2 ATP6V1E1	Dandy-Walker malformation
HPA:0090991	0.0281100167496	0.2	ATP6V1G2 ATP6V0A1 ATP6V1F ATP6V1B2	cerebellum; molecular layer - neuropil[>=Low]
GO:0140657	0.0332494629823	0.35	ATP6V0C ATP6V1B2 ATP6V1F ATP6V1C1 ATP6V1E1 ATP6V1A TCIRG1	ATP-dependent activity
HP:0011885	0.0356886548304	0.15	ATP6V1A ATP6V1E1 ATP6V0A2	Hemorrhage of the eye
GO:0015318	0.0367169462804	0.35	ATP6V0C ATP6V1B2 ATP6V1F ATP6V1C1 ATP6V1E1 ATP6V1A TCIRG1	inorganic molecular entity transmembrane transporter activity
HP:0000455	0.0390298935277	0.2	ATP6V1A ATP6V0A2 ATP6V1B2 ATP6V1E1	Broad nasal tip
GO:0030139	0.0429655799366	0.3	ATP6V0A1 ATP6V0D1 ATP6V0C ATP6V0A2 ATP6V0D2 TCIRG1	endocytic vesicle
GO:0006810	0.0454578857843	0.7	CYBRD1 ATP6V0C ATP6V1A ATP6V1D ATP6V0D2 ATP6V1C1 ATP6V1F ATP6V1B2 ATP6V0A2 ATP6V0A1 TCIRG1 ATP6V1E1 ATP6AP2 ATP6V0D1	transport
HP:0010950	0.046114879642	0.2	ATP6V1A ATP6V0A2 ATP6V1B2 ATP6V1E1	Abnormal fourth ventricle morphology
HP:0002198	0.046114879642	0.2	ATP6V1A ATP6V0A2 ATP6V1B2 ATP6V1E1	Dilated fourth ventricle

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ATP6V1F	ATP6V1B2	1.0	0.462
TMEM199	ATP6V0D1	1.0	0.122
ATP6V1B2	ATP6V1A	1.0	0.832	mutually_exclusive (P15313) structurally_consistent (dimer)
ATP6V1B2	ATP6V1D	1.0	0.65	structurally_consistent (dimer)
ATP6V1D	ATP6V1E1	1.0	0.792	structurally_consistent (P21281)
CCDC115	ATP6V0A1	1.0	0.12
VMA21	ATP6V0D2	1.0
CCDC115	ATP6V0D1	1.0	0.096	structurally_consistent (dimer)
ATP6V1B2	ATP6V1E1	1.0	0.93	structurally_consistent (P15313) structurally_consistent (dimer)
CCDC115	ATP6V0D2	1.0		structurally_consistent (dimer)
ATP6V0A1	ATP6V0D1	1.0	0.412	structurally_consistent (P27449)
TMEM199	ATP6V0C	1.0	0.09	structurally_consistent (dimer)
ATP6V0D2	ATP6V0A1	1.0
VMA21	ATP6AP2	1.0	0.078	structurally_consistent (P27449)
ATP6V1D	ATP6V1A	1.0	0.548	structurally_consistent (dimer)
ATP6V1B1	ATP6V1D	1.0
TMEM199	ATP6V0A1	1.0	0.062	mutually_exclusive (P27449)
ATP6V1B2	ATP6V0D1	1.0	0.274
CCDC115	ATP6V0A2	1.0	0.066
ATP6V1F	ATP6V1B1	1.0
VMA21	ATP6V0A2	1.0	0.008	mutually_exclusive (P27449)
ATP6V1F	ATP6V0A1	1.0	0.104
CCDC115	ATP6AP2	1.0	0.138
ATP6V1B1	ATP6V1G1	1.0
VMA21	ATP6V0D1	1.0	0.05	structurally_consistent (P27449)
TCIRG1	ATP6V0D2	1.0
VMA21	TMEM199	1.0	0.04
ATP6V0D2	TMEM199	1.0		structurally_consistent (P27449)
TMEM199	ATP6V0A2	1.0	0.102	mutually_exclusive (P27449)
ATP6V1E1	ATP6V1A	0.999	0.816
ATP6V0D2	ATP6V0D1	0.999
CCDC115	TMEM199	0.999	0.458	structurally_consistent (dimer)
ATP6V1B1	ATP6V1E1	0.999		structurally_consistent (dimer)
ATP6V1C1	ATP6V1B1	0.999		structurally_consistent (dimer)
ATP6V1B2	ATP6V1B1	0.999		structurally_consistent (dimer)
TCIRG1	TMEM199	0.999	0.062	mutually_exclusive (P27449)
ATP6V1F	TMEM199	0.999	0.164	mutually_exclusive (Q96NT0)
ATP6V0D1	ATP6V1A	0.999	0.376	structurally_consistent (Q9Y5K8)
ATP6V0A2	ATP6V0D1	0.999	0.138
ATP6V1C1	ATP6V1B2	0.999	0.304	structurally_consistent (dimer)
ATP6V1B1	ATP6V1A	0.999		structurally_consistent (dimer)
ATP6V1F	ATP6V0D1	0.999	0.272
ATP6V1E1	ATP6V1G1	0.999	0.92	mutually_exclusive (Q96LB4) structurally_consistent (dimer)
ATP6V0D2	ATP6V0A2	0.999
VMA21	ATP6V0C	0.999	0.052	structurally_consistent (dimer)
ATP6V1C1	ATP6V1D	0.999	0.188	structurally_consistent (dimer)
TCIRG1	VMA21	0.999	0.028	mutually_exclusive (P27449)
ATP6V1F	CCDC115	0.999	0.188	structurally_consistent (dimer)
TCIRG1	ATP6V0D1	0.999	0.254	structurally_consistent (P27449)
ATP6V1D	ATP6V1G1	0.999	0.7
ATP6V1F	ATP6V1G2	0.999	0.062
VMA21	ATP6V0A1	0.999	0.014	mutually_exclusive (P27449)
ATP6V0A2	ATP6V0A1	0.999	0.094	mutually_exclusive (P27449)
ATP6V1F	ATP6V1D	0.999	0.924	structurally_consistent (dimer)
ATP6V0D2	ATP6V0C	0.999		structurally_consistent (dimer)
CCDC115	ATP6V0C	0.999	0.044
ATP6V1F	ATP6V1G1	0.999	0.746
TCIRG1	ATP6V0C	0.999	0.054	structurally_consistent (dimer)
ATP6V0A2	ATP6AP2	0.999	0.06	structurally_consistent (P27449) structurally_consistent (dimer)
ATP6V1D	ATP6V0D1	0.999	0.28	structurally_consistent (dimer)
ATP6V1G2	ATP6V1D	0.999	0.136	structurally_consistent (P21283)
ATP6V1F	ATP6V0A2	0.999	0.074
ATP6V1F	ATP6V0D2	0.999
ATP6V1F	ATP6AP2	0.998	0.054
ATP6V0A1	ATP6AP2	0.998	0.078	structurally_consistent (P27449)
ATP6V0C	ATP6AP2	0.998	0.14	structurally_consistent (Q8N8Y2) structurally_consistent (dimer)
ATP6V1C1	ATP6V1G1	0.998	0.344
ATP6V1C1	ATP6V1G2	0.998	0.058	structurally_consistent (dimer)
ATP6V1F	ATP6V1E1	0.998	0.618
TCIRG1	CCDC115	0.998	0.052
ATP6V1B2	ATP6V1G1	0.998	0.79	mutually_exclusive (Q96A05)
ATP6V0D1	ATP6V0C	0.998	0.216	structurally_consistent (O75787) structurally_consistent (dimer)
TMEM199	ATP6AP2	0.998	0.24	structurally_consistent (P27449)
ATP6V1G1	ATP6V1A	0.998	0.844
ATP6V0A2	ATP6V0C	0.998	0.066	structurally_consistent (O75787) structurally_consistent (dimer)
ATP6V1F	ATP6V1A	0.998	0.606	structurally_consistent (Q9Y5K8)
ATP6V0A1	ATP6V1A	0.998	0.29
ATP6V1E1	ATP6V0A1	0.997	0.13
ATP6V1E1	ATP6V0D1	0.997	0.224
ATP6V1B2	ATP6V0A1	0.997	0.142
ATP6V1G2	ATP6V1A	0.997	0.206
ATP6V1G2	ATP6V1E1	0.997	0.118666666667	structurally_consistent (dimer)
ATP6V1B2	ATP6V0D2	0.997		structurally_consistent (dimer)
ATP6V1G2	ATP6V1B2	0.997	0.156
ATP6V0A1	ATP6V0C	0.997	0.202	structurally_consistent (dimer)
TCIRG1	ATP6AP2	0.997	0.048	structurally_consistent (P27449)
ATP6V1F	ATP6V0C	0.996	0.116
ATP6V1G1	ATP6AP2	0.996	0.1
ATP6V1B2	ATP6V0A2	0.995	0.048
ATP6V1F	TCIRG1	0.995	0.06
ATP6V1G1	ATP6V0A1	0.995	0.132
ATP6V1B2	ATP6AP2	0.995	0.09
ATP6V1G1	ATP6V0D1	0.994	0.14
TCIRG1	ATP6V0A1	0.994	0.106
VMA21	CCDC115	0.994	0.092
ATP6V1G2	ATP6V1G1	0.994	0.06
ATP6V0D2	ATP6AP2	0.994		structurally_consistent (dimer)
ATP6V1D	ATP6V0A1	0.993	0.092
ATP6V1F	ATP6V1C1	0.993	0.196	structurally_consistent (Q9Y5K8)
CCDC115	ATP6V1B2	0.993	0.092	structurally_consistent (Q8N8Y2)
CCDC115	ATP6V1G1	0.993	0.174
ATP6V1G1	ATP6V0A2	0.992	0.102
TCIRG1	ATP6V0A2	0.992	0.062	mutually_exclusive (P27449)
ATP6V1E1	ATP6V0A2	0.992	0.066	structurally_consistent (O75787)
ATP6V0A2	ATP6V1A	0.992	0.1
ATP6V1B2	TMEM199	0.991	0.046
ATP6V1C1	ATP6V1A	0.991	0.29
ATP6V0D1	ATP6AP2	0.991	0.194	structurally_consistent (dimer)
ATP6V1G2	ATP6V1B1	0.99
ATP6V1B1	ATP6V0D1	0.99		structurally_consistent (P21283)
ATP6V1F	VMA21	0.989	0.07
ATP6AP2	ATP6V1A	0.988	0.08	structurally_consistent (Q8N8Y2)
ATP6V1G2	ATP6V0D2	0.987		structurally_consistent (P21283)
ATP6V1C1	ATP6V1E1	0.987	0.23
TCIRG1	ATP6V1B2	0.986	0.126	structurally_consistent (dimer)
ATP6V0D2	ATP6V1A	0.986		structurally_consistent (dimer)
ATP6V1C1	ATP6V0A2	0.986	0.066
ATP6V1G2	ATP6V0A2	0.986	0.126
CYBRD1	GPRC5A	0.986	0.108
ATP6V1G2	ATP6V0A1	0.985	0.164
CYBRD1	ATP6V0D1	0.982	0.1
CCDC115	ATP6V1D	0.982	0.046
TCIRG1	ATP6V1E1	0.981	0.102	structurally_consistent (P21281)
CYBRD1	CCDC115	0.981	0.102
ATP6V0C	ATP6V1A	0.98	0.096	structurally_consistent (Q9Y2Q5)
CYBRD1	TMEM199	0.978	0.098
CCDC115	ATP6V1A	0.977	0.096	structurally_consistent (Q8N8Y2)
ATP6V1G2	ATP6V0D1	0.977	0.206666666667
ATP6V1B1	ATP6V0A1	0.975
TCIRG1	ATP6V1G2	0.975	0.072
ATP6V1D	ATP6V0A2	0.975	0.038
ATP6V1B1	ATP6V0D2	0.973		structurally_consistent (dimer)
TMEM199	ATP6V1A	0.972	0.11
TMEM199	GPRC5A	0.972	0.096
GPRC5A	ATP6V0A1	0.972	0.056
ATP6V1C1	ATP6V0A1	0.971	0.094
CCDC115	GPRC5A	0.971	0.07
TCIRG1	ATP6V1G1	0.97	0.134
ATP6V1C1	ATP6AP2	0.967	0.128
ATP6V1F	GPRC5A	0.967	0.034
ATP6V1G2	ATP6V0C	0.964	0.062
ATP6V1C1	ATP6V0D1	0.963	0.21	structurally_consistent (Q9Y5K8) structurally_consistent (dimer)
ATP6V1E1	ATP6V0D2	0.96
CYBRD1	ATP6V0A1	0.957	0.132
ATP6V1D	ATP6V0D2	0.957
ATP6V1C1	ATP6V0D2	0.955		structurally_consistent (dimer)
TCIRG1	ATP6V1A	0.953	0.146
ATP6V1E1	ATP6AP2	0.951	0.074	structurally_consistent (dimer)
ATP6V0D2	ATP6V1G1	0.95
TCIRG1	ATP6V1C1	0.947	0.156
CCDC115	ATP6V1E1	0.945	0.114
ATP6V1D	TMEM199	0.943	0.106
ATP6V1E1	GPRC5A	0.941	0.032
ATP6V1D	ATP6V0C	0.94	0.048
ATP6V1B2	ATP6V0C	0.939	0.078
GPRC5A	ATP6V0D1	0.935	0.114
ATP6V1B2	GPRC5A	0.935	0.042
ATP6V1C1	ATP6V0C	0.93	0.062
TCIRG1	ATP6V1D	0.927	0.072
ATP6V1B1	ATP6V0A2	0.923
ATP6V1E1	ATP6V0C	0.911	0.042
ATP6V1B1	ATP6V0C	0.907
ATP6V1D	ATP6AP2	0.896	0.018
ATP6V1G1	GPRC5A	0.889	0.074
ATP6V1G1	TMEM199	0.846	0.222
ATP6V1E1	TMEM199	0.825	0.164
CYBRD1	ATP6V1E1	0.796	0.1
GPRC5A	ATP6V1A	0.791	0.076
ATP6V1F	CYBRD1	0.777	0.126
CYBRD1	ATP6V1B2	0.751	0.107333333333
ATP6V1G1	ATP6V0C	0.712	0.08
ATP6V0A2	GPRC5A	0.636	0.06
VMA21	ATP6V1G1	0.621	0.038
VMA21	ATP6V1D	0.597	0.058
TCIRG1	GPRC5A	0.593	0.024
CCDC115	ATP6V1C1	0.54	0.144
ATP6V1C1	TMEM199	0.514	0.216
CYBRD1	ATP6V1A	0.511	0.228
VMA21	ATP6V1C1	0.457	0.042
GPRC5A	ATP6AP2	0.423	0.044
CYBRD1	ATP6AP2	0.288	0.06
CYBRD1	ATP6V0D2	0.279
CYBRD1	ATP6V0A2	0.274	0.104
CYBRD1	ATP6V0C	0.274	0.118
VMA21	ATP6V1B2	0.271	0.032
VMA21	GPRC5A	0.204	0.034
CYBRD1	VMA21	0.133	0.046
ATP6V0D2	GPRC5A	0.133
VMA21	ATP6V1E1	0.127	0.048
GPRC5A	ATP6V0C	0.113	0.066
CYBRD1	ATP6V1G1	0.082	0.1
CYBRD1	TCIRG1	0.08	0.1522
TCIRG1	ATP6V1B1	0.057
VMA21	ATP6V1A	0.051	0.044
ATP6V1D	GPRC5A	0.047	0.022
ATP6V1C1	GPRC5A	0.031	0.032
CYBRD1	ATP6V1D	0.021	0.036
ATP6V1B1	TMEM199	0.014
CCDC115	ATP6V1B1	0.014		structurally_consistent (Q8N8Y2)
VMA21	ATP6V1G2	0.012	0.102

Related Complexes

Genename	Complexes
ATP6V1F	huMAP3_00308.1 huMAP3_01501.1 huMAP3_05444.1 huMAP3_05805.1 huMAP3_07099.1 huMAP3_07329.1 huMAP3_08381.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V1B2	huMAP3_01413.1 huMAP3_01501.1 huMAP3_01899.1 huMAP3_05805.1 huMAP3_07099.1 huMAP3_07329.1 huMAP3_08381.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
GPRC5A	huMAP3_01609.1 huMAP3_04056.1 huMAP3_04452.1 huMAP3_05687.1 huMAP3_05805.1 huMAP3_08151.1 huMAP3_08166.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09440.1 huMAP3_09562.1 huMAP3_10725.1 huMAP3_12042.1
CYBRD1	huMAP3_00361.1 huMAP3_01609.1 huMAP3_05805.1 huMAP3_06790.1 huMAP3_08151.1 huMAP3_08166.1 huMAP3_09440.1 huMAP3_09562.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V1G1	huMAP3_01501.1 huMAP3_05805.1 huMAP3_07099.1 huMAP3_07329.1 huMAP3_08381.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
TCIRG1	huMAP3_01038.1 huMAP3_01501.1 huMAP3_02239.1 huMAP3_05374.1 huMAP3_05805.1 huMAP3_07329.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_08678.1 huMAP3_09324.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13060.1 huMAP3_13872.1
ATP6AP2	huMAP3_04131.1 huMAP3_05374.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08182.1 huMAP3_09477.1 huMAP3_09505.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V1D	huMAP3_01413.1 huMAP3_05805.1 huMAP3_07099.1 huMAP3_07329.1 huMAP3_08381.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V1B1	huMAP3_01413.1 huMAP3_01501.1 huMAP3_01899.1 huMAP3_05805.1 huMAP3_07099.1 huMAP3_07329.1 huMAP3_08381.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
TMEM199	huMAP3_01538.1 huMAP3_04056.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V0A1	huMAP3_01609.1 huMAP3_04131.1 huMAP3_05444.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08381.1 huMAP3_08751.1 huMAP3_09440.1 huMAP3_09477.1 huMAP3_09505.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V1E1	huMAP3_01413.1 huMAP3_01501.1 huMAP3_01899.1 huMAP3_05805.1 huMAP3_07099.1 huMAP3_07329.1 huMAP3_08381.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V1C1	huMAP3_01413.1 huMAP3_05070.1 huMAP3_05805.1 huMAP3_07099.1 huMAP3_07329.1 huMAP3_08381.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
VMA21	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
CCDC115	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V0D1	huMAP3_02239.1 huMAP3_05444.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08381.1 huMAP3_08621.1 huMAP3_09477.1 huMAP3_09505.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V1G2	huMAP3_01413.1 huMAP3_04524.1 huMAP3_05805.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0D2	huMAP3_01501.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07329.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08678.1 huMAP3_09477.1 huMAP3_09562.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V1A	huMAP3_05070.1 huMAP3_05805.1 huMAP3_07099.1 huMAP3_07329.1 huMAP3_08381.1 huMAP3_08678.1 huMAP3_09242.1 huMAP3_09477.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0C	huMAP3_03313.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08494.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0A2	huMAP3_01575.1 huMAP3_02239.1 huMAP3_03999.1 huMAP3_05374.1 huMAP3_05805.1 huMAP3_07558.1 huMAP3_08032.1 huMAP3_08182.1 huMAP3_09324.1 huMAP3_09565.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13872.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05805.1

Complex Portal: CPX-25276