hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05806.1

Complex Portal: CPX-18654

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PRKCZ	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)	5	UniProt NCBI
PARD6G	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)	5	UniProt NCBI
LLGL1	Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)	5	UniProt NCBI
PARD3	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	5	UniProt NCBI
ZNF3	Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25)	5	UniProt NCBI
PRKCI	Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)	5	UniProt NCBI
PARD6B	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)	5	UniProt NCBI
PARD6A	Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0120157	2.58853125713e-17	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	PAR polarity complex
GO:0045197	2.23615080628e-14	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	establishment or maintenance of epithelial cell apical/basal polarity
GO:0061245	3.983517312e-14	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	establishment or maintenance of bipolar cell polarity
GO:0035088	3.983517312e-14	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	establishment or maintenance of apical/basal cell polarity
KEGG:04530	3.15558911241e-13	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	Tight junction
KEGG:04390	4.48427005645e-13	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	Hippo signaling pathway
REAC:R-HSA-420029	2.19843524306e-12	0.714285714286	PARD6A PARD6G PARD6B PARD3 PRKCI	Tight junction interactions
WP:WP5090	2.71175432615e-11	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	Complement system in neuronal development and plasticity
KEGG:05165	6.48359679001e-11	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	Human papillomavirus infection
GO:0007163	6.8957678217e-10	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	establishment or maintenance of cell polarity
KEGG:04015	7.09943130145e-10	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	Rap1 signaling pathway
REAC:R-HSA-421270	8.91364830799e-10	0.714285714286	PARD6A PARD6G PARD6B PARD3 PRKCI	Cell-cell junction organization
GO:0070160	3.38123378566e-09	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	tight junction
KEGG:04144	5.27021627566e-09	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	Endocytosis
CORUM:956	7.02338504734e-09	0.428571428571	PARD6B PARD3 PRKCI	PAR-3-PAR-6B-PRKCI complex
CORUM:959	7.02338504734e-09	0.428571428571	LLGL1 PRKCI PARD6B	LLGL1-PAR-6B-PRKCI complex
REAC:R-HSA-446728	1.01763939558e-08	0.714285714286	PARD6A PARD6G PARD6B PARD3 PRKCI	Cell junction organization
CORUM:7444	2.80877722849e-08	0.428571428571	PARD6A PARD3 PRKCI	HOOK2-PAR3-Par6alpha-PKCiota complex
REAC:R-HSA-1500931	6.34450954374e-08	0.714285714286	PARD6A PARD6G PARD6B PARD3 PRKCI	Cell-Cell communication
CORUM:905	7.02050133195e-08	0.428571428571	PARD6A PARD3 PRKCI	KIF3A/B-PAR-3-aPKC-PAR-6 complex
GO:0005911	7.86865937855e-08	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	cell-cell junction
GO:1902554	1.26591613084e-07	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	serine/threonine protein kinase complex
KEGG:04360	1.31171068017e-07	0.714285714286	PARD6A PRKCZ PARD6B PARD3 PARD6G	Axon guidance
GO:1902911	2.74208761158e-07	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	protein kinase complex
REAC:R-HSA-2173791	5.91838682973e-06	0.428571428571	PRKCZ PARD3 PARD6A	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
GO:0070161	1.11756958291e-05	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	anchoring junction
GO:0061695	1.48074113953e-05	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	transferase complex, transferring phosphorus-containing groups
WP:WP5381	2.500856884e-05	0.571428571429	LLGL1 PARD6B PARD3 PRKCI	Smith Magenis and Potocki Lupski syndrome copy number variation
CORUM:7300	6.1565588648e-05	0.285714285714	PARD6A PRKCI	PARD3B-PARD6A-PRKCI complex
CORUM:5535	6.1565588648e-05	0.285714285714	PARD6A PARD3	PLCB3-PARD3-PARD6A complex
CORUM:5534	6.1565588648e-05	0.285714285714	PARD6A PARD3	PLCB1-PARD3-PARD6A complex
CORUM:955	6.1565588648e-05	0.285714285714	PRKCI PARD6B	LLGL2-PAR-6B-PRKCI complex
CORUM:918	6.1565588648e-05	0.285714285714	PARD6A PARD3	PAR3-PAR6-PALS1 complex
CORUM:847	6.1565588648e-05	0.285714285714	PARD3 PRKCI	RICH1-PAR3-aPKC polarity complex
CORUM:831	6.1565588648e-05	0.285714285714	PARD6A PARD3	PAR-6-PAR-3-VE-cadherin complex, endothelial
GO:0005938	0.000232620911116	0.714285714286	PARD6A PARD6G PARD6B PARD3 LLGL1	cell cortex
GO:0030054	0.000952363989281	1.0	LLGL1 PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	cell junction
REAC:R-HSA-170834	0.00135845178782	0.428571428571	PRKCZ PARD3 PARD6A	Signaling by TGF-beta Receptor Complex
REAC:R-HSA-9006936	0.0026052001297	0.428571428571	PRKCZ PARD3 PARD6A	Signaling by TGFB family members
GO:1990234	0.0074086488747	0.857142857143	PRKCZ PRKCI PARD6B PARD6G PARD6A PARD3	transferase complex
WP:WP5283	0.00933842806825	0.285714285714	PRKCZ PRKCI	Chronic hyperglycemia impairment of neuron function
GO:0045216	0.011574920454	0.571428571429	PARD6A PARD6B PARD3 PRKCI	cell-cell junction organization
REAC:R-HSA-9013424	0.0225049419259	0.285714285714	PARD6A PARD6B	RHOV GTPase cycle
WP:WP5345	0.039968890476	0.285714285714	PRKCZ PARD6B	1p36 copy number variation syndrome
GO:0016324	0.041318088432	0.571428571429	PARD6A PARD6G PARD3 PARD6B	apical plasma membrane
GO:0000226	0.0424991667123	0.714285714286	PARD6A PARD6G PARD6B PARD3 LLGL1	microtubule cytoskeleton organization
KEGG:04611	0.047723469919	0.285714285714	PRKCZ PRKCI	Platelet activation

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
PRKCI	PARD6B	1.0	0.106	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
LLGL1	PARD6B	1.0	0.12		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
PRKCZ	PARD6B	1.0	0.168	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
PRKCI	LLGL1	0.999	0.108		hein_WMM bioplex_WMM bioplex3_WMM hein () Malo gupta_WMM fraction treiber_WMM
PRKCI	PRKCZ	0.999	0.336	mutually_exclusive (Q9BYG5)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PARD6A	PRKCZ	0.999		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PARD6G	PRKCZ	0.999		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PARD3	PARD6B	0.998	0.116		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
PARD6G	PARD6B	0.998			bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
PRKCZ	LLGL1	0.997	0.094	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKCI	PARD6G	0.995			bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
PARD3	PRKCI	0.983	0.068		hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM
ZNF3	LLGL1	0.978	0.082		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
ZNF3	PARD6B	0.962	0.096		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PRKCI	PARD6A	0.959			hein_WMM bioplex_WMM bioplex3_WMM hein ()
PARD6A	PARD6B	0.957		structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
ZNF3	PRKCI	0.952	0.098		hein_WMM bioplex_WMM bioplex3_WMM hein ()
PARD3	PRKCZ	0.893	0.14		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PARD6G	PARD6A	0.887		mutually_exclusive (Q05513)	bioplex_WMM bioplex3_WMM WMM_only
PARD3	LLGL1	0.864	0.034		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
PARD6A	LLGL1	0.862		mutually_exclusive (Q05513)	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PARD6G	LLGL1	0.815			bioplex_WMM bioplex3_WMM WMM_only
ZNF3	PARD6A	0.192			hein_WMM WMM_only
PARD3	PARD6G	0.07			bioplex3_WMM WMM_only boldt_WMM
PARD3	PARD6A	0.063			hein_WMM WMM_only
ZNF3	PARD6G	0.055			bioplex3_WMM WMM_only
PARD3	ZNF3	0.049	0.064		hein_WMM WMM_only
ZNF3	PRKCZ	0.013	0.158		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PRKCZ	huMAP3_02982.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08694.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD6G	huMAP3_01634.1 huMAP3_01836.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1 huMAP3_14802.1
LLGL1	huMAP3_03400.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD3	huMAP3_00531.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_06269.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09726.1 huMAP3_09810.1 huMAP3_10212.1 huMAP3_10898.1 huMAP3_12987.1 huMAP3_14118.1
ZNF3	huMAP3_01206.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PRKCI	huMAP3_01206.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD6B	huMAP3_03400.1 huMAP3_05806.1 huMAP3_05836.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD6A	huMAP3_02982.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05806.1

Complex Portal: CPX-18654