hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05816.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COPS7B | COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b) | 5 | UniProt NCBI |
| COPS8 | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) | 5 | UniProt NCBI |
| KLHDC3 | Kelch domain-containing protein 3 (Testis intracellular mediator protein) | 5 | UniProt NCBI |
| COPS2 | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | 5 | UniProt NCBI |
| COPS7A | COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) | 5 | UniProt NCBI |
| NEDD8 | NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8) | 5 | UniProt NCBI |
| COPS3 | COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) | 5 | UniProt NCBI |
| COPS6 | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045116 | 1.25727408474e-14 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | protein neddylation |
| GO:0000338 | 2.17334574806e-14 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | protein deneddylation |
| CORUM:2174 | 5.15023279265e-14 | 0.625 | COPS7A COPS8 COPS6 COPS3 COPS2 | COP9 signalosome complex |
| CORUM:2179 | 1.1586040571e-13 | 0.625 | COPS7A COPS8 COPS6 COPS3 COPS2 | CNS-P53 complex |
| REAC:R-HSA-8856825 | 6.14201137074e-13 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | Cargo recognition for clathrin-mediated endocytosis |
| CORUM:728 | 7.27891517895e-13 | 0.625 | COPS7A COPS8 COPS6 COPS3 COPS2 | CSA-POLIIa complex |
| CORUM:727 | 7.27891517895e-13 | 0.625 | COPS7A COPS8 COPS6 COPS3 COPS2 | CSA complex |
| CORUM:726 | 7.27891517895e-13 | 0.625 | COPS7A COPS8 COPS6 COPS3 COPS2 | DDB2 complex |
| REAC:R-HSA-5696394 | 1.21179577244e-12 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | DNA Damage Recognition in GG-NER |
| GO:2000434 | 2.80499724506e-12 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | regulation of protein neddylation |
| REAC:R-HSA-8856828 | 7.85692930026e-12 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | Clathrin-mediated endocytosis |
| REAC:R-HSA-6781823 | 8.92163224206e-12 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | Formation of TC-NER Pre-Incision Complex |
| GO:0008180 | 9.35422010656e-11 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | COP9 signalosome |
| REAC:R-HSA-6781827 | 1.0359526096e-10 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 1.64804394994e-10 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-8951664 | 3.13807721233e-10 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | Neddylation |
| REAC:R-HSA-5696398 | 8.33053190096e-10 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | Nucleotide Excision Repair |
| WP:WP4352 | 1.98621000558e-08 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | Ciliary landscape |
| GO:0070646 | 5.55736216522e-08 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | protein modification by small protein removal |
| REAC:R-HSA-199991 | 2.26021980743e-07 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | Membrane Trafficking |
| REAC:R-HSA-5653656 | 3.30629466857e-07 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | Vesicle-mediated transport |
| WP:WP5381 | 3.74880037388e-07 | 0.625 | COPS7A COPS8 COPS6 COPS3 COPS2 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-73894 | 4.61531800224e-07 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | DNA Repair |
| GO:1903320 | 5.7333671086e-06 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | regulation of protein modification by small protein conjugation or removal |
| GO:1901873 | 6.3104940629e-06 | 0.75 | COPS6 COPS7A COPS3 COPS2 COPS8 COPS7B | regulation of post-translational protein modification |
| REAC:R-HSA-597592 | 4.69663990309e-05 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | Post-translational protein modification |
| GO:0032446 | 6.3647664603e-05 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | protein modification by small protein conjugation |
| GO:0070647 | 0.000126962382918 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | protein modification by small protein conjugation or removal |
| GO:0043687 | 0.000200817178726 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | post-translational protein modification |
| REAC:R-HSA-392499 | 0.000450218945101 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | Metabolism of proteins |
| GO:0051246 | 0.0475013249603 | 0.875 | COPS6 COPS2 COPS7A COPS3 NEDD8 COPS8 COPS7B | regulation of protein metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| COPS7B | COPS6 | 1.0 | 0.764 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| COPS8 | COPS6 | 1.0 | 0.844 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| COPS7B | COPS2 | 1.0 | 0.668 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM |
| COPS3 | COPS6 | 1.0 | 0.884 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| COPS7B | COPS8 | 1.0 | 0.534 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| COPS8 | COPS7A | 1.0 | 0.23 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| COPS2 | COPS6 | 1.0 | 0.962 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM |
| COPS7A | COPS6 | 0.999 | 0.648 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| COPS8 | COPS2 | 0.999 | 0.588 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM |
| COPS7A | COPS3 | 0.999 | 0.462 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| COPS2 | COPS3 | 0.999 | 0.952 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM |
| COPS8 | COPS3 | 0.999 | 0.666 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| COPS7B | COPS3 | 0.999 | 0.412 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
| COPS2 | COPS7A | 0.999 | 0.59 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| NEDD8 | COPS8 | 0.998 | 0.21 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NEDD8 | COPS2 | 0.998 | 0.38 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NEDD8 | KLHDC3 | 0.996 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| NEDD8 | COPS3 | 0.994 | 0.33 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
| COPS7B | COPS7A | 0.993 | 0.248 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| NEDD8 | COPS6 | 0.992 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| KLHDC3 | COPS2 | 0.988 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NEDD8 | COPS7A | 0.982 | 0.212 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KLHDC3 | COPS3 | 0.979 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KLHDC3 | COPS6 | 0.972 | 0.186 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KLHDC3 | COPS7A | 0.964 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| COPS8 | KLHDC3 | 0.962 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| COPS7B | KLHDC3 | 0.959 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NEDD8 | COPS7B | 0.55 | 0.096 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes