hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05825.1
Complex Portal: CPX-23400
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GALK1 | Galactokinase (EC 2.7.1.6) (Galactose kinase) | 5 | UniProt NCBI |
| VPS4A | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) | 5 | UniProt NCBI |
| MSH6 | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | 5 | UniProt NCBI |
| ZFYVE19 | Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001392 | 0.00953454865728 | 1.0 | GALK1 MSH6 ZFYVE19 VPS4A | Abnormality of the liver |
| GO:0044878 | 0.0168521501606 | 0.5 | VPS4A ZFYVE19 | mitotic cytokinesis checkpoint signaling |
| HP:0002012 | 0.0205007275068 | 1.0 | GALK1 MSH6 ZFYVE19 VPS4A | Abnormality of the abdominal organs |
| HP:0004297 | 0.0255174052948 | 0.75 | GALK1 ZFYVE19 VPS4A | Abnormality of the biliary system |
| HP:0100613 | 0.0329787201379 | 0.5 | VPS4A MSH6 | Death in early adulthood |
| HP:0033763 | 0.036003514982 | 0.5 | VPS4A MSH6 | Death in adulthood |
| GO:0009838 | 0.042122686785 | 0.5 | VPS4A ZFYVE19 | abscission |
| GO:0032466 | 0.042122686785 | 0.5 | VPS4A ZFYVE19 | negative regulation of cytokinesis |
| CORUM:286 | 0.049938562206 | 0.25 | MSH6 | PCNA-MSH2-MSH6 complex |
| CORUM:289 | 0.049938562206 | 0.25 | MSH6 | PCNA-MSH2-MSH6 complex |
| CORUM:374 | 0.049938562206 | 0.25 | MSH6 | MSH2-MSH6 complex |
| CORUM:377 | 0.049938562206 | 0.25 | MSH6 | PCNA-MSH2-MSH6 complex |
| CORUM:1078 | 0.049938562206 | 0.25 | MSH6 | MSH2-MSH6 complex |
| CORUM:2740 | 0.049938562206 | 0.25 | MSH6 | MSH2-MSH6 complex |
| REAC:R-HSA-5609976 | 0.0499436884912 | 0.25 | GALK1 | Defective GALK1 causes GALCT2 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZFYVE19 | VPS4A | 0.982 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VPS4A | GALK1 | 0.969 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM | |
| MSH6 | GALK1 | 0.959 | 0.046 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| MSH6 | VPS4A | 0.688 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
Related Complexes