hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05832.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
XPO4	Exportin-4 (Exp4)	5	UniProt NCBI
TNPO2	Transportin-2 (Karyopherin beta-2b)	5	UniProt NCBI
EIF2B3	Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma)	5	UniProt NCBI
XPO7	Exportin-7 (Exp7) (Ran-binding protein 16)	5	UniProt NCBI
XPO6	Exportin-6 (Exp6) (Ran-binding protein 20)	5	UniProt NCBI
MTOR	Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)	5	UniProt NCBI
NUP85	Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1)	5	UniProt NCBI
XPO5	Exportin-5 (Exp5) (Ran-binding protein 21)	5	UniProt NCBI
EIF2B4	Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)	5	UniProt NCBI
TNPO3	Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)	5	UniProt NCBI
SAAL1	Protein SAAL1 (Synoviocyte proliferation-associated in collagen-induced arthritis protein 1) (SPACIA1)	3	UniProt NCBI
VSIG2	V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein)	4	UniProt NCBI
THADA	tRNA (32-2'-O)-methyltransferase regulator THADA (Gene inducing thyroid adenomas protein) (Thyroid adenoma-associated protein)	5	UniProt NCBI
CIP2A	Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03013	1.11834381178e-10	0.5	XPO5 TNPO2 XPO4 XPO7 NUP85 XPO6 TNPO3	Nucleocytoplasmic transport
GO:0140142	3.2548660699e-09	0.428571428571	XPO5 TNPO3 XPO4 XPO7 XPO6 TNPO2	nucleocytoplasmic carrier activity
GO:0140104	3.22284568148e-06	0.428571428571	XPO5 TNPO3 XPO4 XPO7 XPO6 TNPO2	molecular carrier activity
GO:0005049	8.65858915641e-06	0.285714285714	XPO4 XPO5 XPO6 XPO7	nuclear export signal receptor activity
GO:0006913	4.86579425541e-05	0.5	XPO5 TNPO2 XPO4 XPO7 NUP85 XPO6 TNPO3	nucleocytoplasmic transport
GO:0051169	4.86579425541e-05	0.5	XPO5 TNPO2 XPO4 XPO7 NUP85 XPO6 TNPO3	nuclear transport
CORUM:7291	0.000266552996475	0.142857142857	EIF2B4 EIF2B3	EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
CORUM:7292	0.000444011791638	0.142857142857	EIF2B4 EIF2B3	EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex
GO:0006611	0.00349800823415	0.285714285714	XPO4 XPO5 XPO6 XPO7	protein export from nucleus
GO:0006886	0.00595184011417	0.5	XPO5 TNPO2 XPO4 XPO7 NUP85 XPO6 TNPO3	intracellular protein transport
REAC:R-HSA-72731	0.00668012550606	0.142857142857	EIF2B4 EIF2B3	Recycling of eIF2:GDP
GO:0051168	0.00752703439258	0.357142857143	XPO4 XPO5 NUP85 XPO6 XPO7	nuclear export
WP:WP5316	0.0265444294999	0.214285714286	XPO5 EIF2B3 EIF2B4	Primary ovarian insufficiency

Edges

Protein 1	Protein 2	Score	ProteomeHD
EIF2B4	EIF2B3	0.997	0.436
XPO6	XPO7	0.996	0.096
XPO5	VSIG2	0.994
XPO6	NUP85	0.993	0.19
VSIG2	TNPO3	0.993
VSIG2	XPO4	0.991
THADA	SAAL1	0.99	0.214
XPO6	TNPO2	0.99	0.034
MTOR	XPO6	0.989	0.088
EIF2B4	XPO4	0.988	0.05
SAAL1	TNPO3	0.988	0.078
XPO4	XPO7	0.988	0.52
XPO6	SAAL1	0.987	0.134
MTOR	XPO4	0.986	0.098
XPO6	THADA	0.986	0.234
XPO6	XPO4	0.985	0.088
MTOR	SAAL1	0.985	0.146
XPO4	EIF2B3	0.983	0.35
MTOR	TNPO3	0.983	0.172
MTOR	TNPO2	0.983	0.262714285714
VSIG2	TNPO2	0.982
EIF2B3	CIP2A	0.981	0.054
EIF2B4	TNPO2	0.979	0.026
XPO4	NUP85	0.976	0.204
XPO6	CIP2A	0.975	0.094
XPO5	XPO6	0.975	0.152
XPO6	TNPO3	0.975	0.18
EIF2B4	TNPO3	0.975	0.134
EIF2B3	TNPO3	0.975	0.24
SAAL1	TNPO2	0.973	0.026
MTOR	XPO7	0.972	0.25
EIF2B4	CIP2A	0.971	0.024
XPO6	VSIG2	0.97
EIF2B3	TNPO2	0.97	0.076
XPO4	SAAL1	0.966	0.092
EIF2B4	SAAL1	0.966	0.1
MTOR	THADA	0.964	0.09
MTOR	CIP2A	0.964	0.11
XPO5	XPO4	0.963	0.254
EIF2B4	XPO6	0.962	0.042
THADA	XPO4	0.962	0.082
XPO4	TNPO2	0.962	0.06
SAAL1	XPO7	0.958	0.034
XPO7	NUP85	0.956	0.232
EIF2B4	THADA	0.951	0.078
SAAL1	CIP2A	0.951	0.14
SAAL1	EIF2B3	0.95	0.066
VSIG2	SAAL1	0.948
XPO4	CIP2A	0.946	0.03
SAAL1	NUP85	0.944	0.08
MTOR	XPO5	0.943	0.174
VSIG2	THADA	0.941
XPO5	SAAL1	0.934	0.244
XPO7	TNPO3	0.932	0.21
THADA	TNPO2	0.931	0.04
TNPO2	TNPO3	0.928	0.124
THADA	TNPO3	0.915	0.166
NUP85	TNPO2	0.915	0.138
EIF2B3	NUP85	0.91	0.116
THADA	XPO7	0.907	0.13
XPO4	TNPO3	0.9	0.134
NUP85	TNPO3	0.877	0.218
EIF2B4	NUP85	0.873	0.21
XPO5	XPO7	0.869	0.18
THADA	NUP85	0.847	0.158
XPO7	TNPO2	0.847	0.348
VSIG2	CIP2A	0.838
CIP2A	TNPO3	0.837	0.046
XPO5	TNPO3	0.836	0.214
EIF2B4	XPO7	0.819	0.102
EIF2B3	XPO7	0.817	0.204
THADA	EIF2B3	0.814	0.092
XPO6	EIF2B3	0.803	0.108
VSIG2	XPO7	0.729
THADA	CIP2A	0.691	0.228
CIP2A	XPO7	0.671	0.036
XPO5	THADA	0.635	0.12
XPO5	TNPO2	0.544	0.102
MTOR	NUP85	0.532	0.248
CIP2A	NUP85	0.51	0.076
XPO5	NUP85	0.508	0.136
CIP2A	TNPO2	0.499	0.022
MTOR	EIF2B4	0.424	0.09
XPO5	CIP2A	0.394	0.07
XPO5	EIF2B3	0.261	0.142
EIF2B4	XPO5	0.143	0.14
MTOR	VSIG2	0.139
MTOR	EIF2B3	0.079	0.182
VSIG2	NUP85	0.049

Related Complexes

Genename	Complexes
XPO4	huMAP3_02351.1 huMAP3_03807.1 huMAP3_05832.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_08936.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
TNPO2	huMAP3_05832.1 huMAP3_06077.1 huMAP3_08177.1 huMAP3_09053.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
EIF2B3	huMAP3_03231.1 huMAP3_04876.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1 huMAP3_12208.1
XPO7	huMAP3_03807.1 huMAP3_05750.1 huMAP3_05832.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1 huMAP3_12744.1
XPO6	huMAP3_01859.1 huMAP3_04713.1 huMAP3_05832.1 huMAP3_06022.1 huMAP3_07746.1 huMAP3_08298.1 huMAP3_09114.1 huMAP3_09379.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
MTOR	huMAP3_00606.1 huMAP3_01859.1 huMAP3_05649.1 huMAP3_05832.1 huMAP3_06022.1 huMAP3_07746.1 huMAP3_08298.1 huMAP3_09114.1 huMAP3_09379.1 huMAP3_09992.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
NUP85	huMAP3_04548.1 huMAP3_05832.1 huMAP3_08298.1 huMAP3_08489.1 huMAP3_09114.1 huMAP3_09825.1 huMAP3_10202.1 huMAP3_11232.1 huMAP3_12581.1
XPO5	huMAP3_01355.1 huMAP3_01859.1 huMAP3_04713.1 huMAP3_05832.1 huMAP3_06077.1 huMAP3_07395.1 huMAP3_08298.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1
EIF2B4	huMAP3_00951.1 huMAP3_03018.1 huMAP3_05832.1 huMAP3_07141.1 huMAP3_08370.1 huMAP3_08485.1 huMAP3_08968.1 huMAP3_09088.1 huMAP3_09338.1 huMAP3_09781.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1 huMAP3_11700.1
TNPO3	huMAP3_05832.1 huMAP3_06077.1 huMAP3_08298.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
SAAL1	huMAP3_02551.1 huMAP3_05832.1 huMAP3_06130.1 huMAP3_08301.1 huMAP3_09114.1 huMAP3_09399.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1 huMAP3_12678.1
VSIG2	huMAP3_01859.1 huMAP3_04713.1 huMAP3_05832.1 huMAP3_06022.1 huMAP3_07746.1 huMAP3_08298.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
THADA	huMAP3_01859.1 huMAP3_05832.1 huMAP3_06022.1 huMAP3_08298.1 huMAP3_08658.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_11232.1
CIP2A	huMAP3_03231.1 huMAP3_05832.1 huMAP3_06130.1 huMAP3_08298.1 huMAP3_08301.1 huMAP3_08370.1 huMAP3_09053.1 huMAP3_09114.1 huMAP3_10202.1 huMAP3_10287.1 huMAP3_10530.1 huMAP3_11232.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05832.1