hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05842.1
Complex Portal: CPX-17837
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2M | NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M) | 5 | UniProt NCBI |
| DCUN1D1 | DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) | 5 | UniProt NCBI |
| UBA3 | NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045116 | 0.000281151120149 | 1.0 | UBE2M UBA3 DCUN1D1 | protein neddylation |
| REAC:R-HSA-8951664 | 0.000874039130798 | 1.0 | UBE2M UBA3 DCUN1D1 | Neddylation |
| KEGG:04120 | 0.00686279305854 | 0.666666666667 | UBE2M UBA3 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-5676590 | 0.0112421146161 | 0.666666666667 | UBE2M UBA3 | NIK-->noncanonical NF-kB signaling |
| REAC:R-HSA-5607761 | 0.0116360425406 | 0.666666666667 | UBE2M UBA3 | Dectin-1 mediated noncanonical NF-kB signaling |
| REAC:R-HSA-5668541 | 0.0248259565326 | 0.666666666667 | UBE2M UBA3 | TNFR2 non-canonical NF-kB pathway |
| REAC:R-HSA-5607764 | 0.0271982878007 | 0.666666666667 | UBE2M UBA3 | CLEC7A (Dectin-1) signaling |
| GO:0019788 | 0.0294899169624 | 0.666666666667 | UBE2M UBA3 | NEDD8 transferase activity |
| REAC:R-HSA-5621481 | 0.0484217025219 | 0.666666666667 | UBE2M UBA3 | C-type lectin receptors (CLRs) |
| CORUM:2162 | 0.0499402709677 | 0.333333333333 | UBA3 | APPBP1-UBA3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UBE2M | UBA3 | 0.995 | 0.276 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DCUN1D1 | UBE2M | 0.985 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DCUN1D1 | UBA3 | 0.351 | 0.25 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| UBE2M | huMAP3_03710.1 huMAP3_05842.1 huMAP3_14442.1 |
| DCUN1D1 | huMAP3_01275.1 huMAP3_05842.1 huMAP3_05855.1 huMAP3_07859.1 huMAP3_10957.1 huMAP3_12888.1 huMAP3_13857.1 huMAP3_14813.1 |
| UBA3 | huMAP3_03710.1 huMAP3_05842.1 huMAP3_11227.1 |