hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05843.1

Complex Portal: CPX-24282

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
SYNRG	Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin)	5	UniProt NCBI
KIF13A	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN)	5	UniProt NCBI
HEATR5B	HEAT repeat-containing protein 5B	5	UniProt NCBI
AP1G2	AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad)	5	UniProt NCBI
AP1M1	AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)	5	UniProt NCBI
AFTPH	Aftiphilin	5	UniProt NCBI
AP1M2	AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin)	5	UniProt NCBI
MEA1	Male-enhanced antigen 1 (MEA-1)	3	UniProt NCBI
AP1S3	AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin)	5	UniProt NCBI
AP1S2	AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)	5	UniProt NCBI
AP1G1	AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)	5	UniProt NCBI
AP1AR	AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0030121	2.16042107362e-20	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	AP-1 adaptor complex
CORUM:144	6.14226580289e-20	0.583333333333	AP1M1 AP1G2 AP1G1 AP1AR AP1S3 AP1S2 AP1M2	Gamma-BAR-AP1 complex
GO:0030130	2.37530622123e-19	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	clathrin coat of trans-Golgi network vesicle
GO:0012510	1.44031747814e-18	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	trans-Golgi network transport vesicle membrane
GO:0030131	2.09670471085e-17	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	clathrin adaptor complex
CORUM:36	1.16307500942e-16	0.5	AP1M1 AP1G2 AP1G1 AP1S3 AP1S2 AP1M2	AP1 adaptor complex
GO:0030140	1.48565280011e-15	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	trans-Golgi network transport vesicle
GO:0030125	2.05111579292e-15	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	clathrin vesicle coat
GO:0030119	1.12307793378e-14	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	AP-type membrane coat adaptor complex
GO:0030118	2.93291672476e-14	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	clathrin coat
GO:0030660	1.02606720305e-13	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	Golgi-associated vesicle membrane
GO:0030120	7.84273716274e-13	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	vesicle coat
GO:0005798	3.95693089918e-12	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	Golgi-associated vesicle
REAC:R-HSA-164940	9.74753896145e-12	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	Nef mediated downregulation of MHC class I complex cell surface expression
REAC:R-HSA-432720	2.03726931398e-11	0.5	AP1M1 AP1G2 AP1G1 AP1S3 AP1S2 AP1M2	Lysosome Vesicle Biogenesis
GO:0030117	2.75313918234e-11	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	membrane coat
GO:0048475	2.75313918234e-11	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	coated membrane
GO:0030665	4.38021256538e-11	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	clathrin-coated vesicle membrane
GO:0030658	2.7677949456e-10	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	transport vesicle membrane
REAC:R-HSA-164938	7.83662057416e-10	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
GO:0030133	1.22877501374e-09	0.75	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1AR AP1S3 AP1S2 AP1G2	transport vesicle
GO:0030136	1.74795145104e-09	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	clathrin-coated vesicle
GO:0030662	2.06839443535e-09	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	coated vesicle membrane
REAC:R-HSA-199992	2.38046878272e-09	0.5	AP1M1 AP1G2 AP1G1 AP1S3 AP1S2 AP1M2	trans-Golgi Network Vesicle Budding
REAC:R-HSA-164952	3.10155279603e-09	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	The role of Nef in HIV-1 replication and disease pathogenesis
GO:0032588	1.10756159818e-08	0.583333333333	AP1M1 AP1M2 AFTPH KIF13A AP1G1 AP1S3 AP1S2	trans-Golgi network membrane
KEGG:04142	1.44822067403e-08	0.5	AP1M1 AP1G2 AP1G1 AP1S3 AP1S2 AP1M2	Lysosome
GO:0030135	6.08735891658e-08	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	coated vesicle
REAC:R-HSA-432722	1.20194784985e-07	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	Golgi Associated Vesicle Biogenesis
KEGG:05170	2.20622425067e-07	0.5	AP1M1 AP1G2 AP1G1 AP1S3 AP1S2 AP1M2	Human immunodeficiency virus 1 infection
GO:0032438	2.65540852718e-06	0.416666666667	AP1M1 AP1S2 AP1G1 KIF13A AP1S3	melanosome organization
GO:0048753	2.65540852718e-06	0.416666666667	AP1M1 AP1S2 AP1G1 KIF13A AP1S3	pigment granule organization
GO:0005802	5.3704597417e-06	0.583333333333	AP1M1 AP1M2 AFTPH KIF13A AP1G1 AP1S3 AP1S2	trans-Golgi network
REAC:R-HSA-2132295	6.20911383484e-06	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	MHC class II antigen presentation
REAC:R-HSA-162909	8.66346381214e-06	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	Host Interactions of HIV factors
GO:0035615	1.29807707416e-05	0.333333333333	AP1M1 AP1G1 AP1G2 AP1M2	clathrin adaptor activity
GO:0098791	1.66704918495e-05	0.583333333333	AP1M1 AP1M2 AFTPH KIF13A AP1G1 AP1S3 AP1S2	Golgi apparatus subcompartment
GO:0140312	1.76932944819e-05	0.333333333333	AP1M1 AP1G1 AP1G2 AP1M2	cargo adaptor activity
GO:0005794	2.06512653192e-05	0.833333333333	AFTPH AP1M2 AP1M1 KIF13A AP1G1 SYNRG AP1AR AP1S3 AP1S2 AP1G2	Golgi apparatus
GO:0031410	2.09218670763e-05	0.916666666667	AP1M1 AP1G2 AFTPH HEATR5B KIF13A SYNRG AP1AR AP1S3 AP1G1 AP1S2 AP1M2	cytoplasmic vesicle
GO:0097708	2.13388750074e-05	0.916666666667	AP1M1 AP1G2 AFTPH HEATR5B KIF13A SYNRG AP1AR AP1S3 AP1G1 AP1S2 AP1M2	intracellular vesicle
GO:0030659	2.28132916513e-05	0.75	AFTPH AP1M2 AP1M1 KIF13A AP1G1 SYNRG AP1S3 AP1S2 AP1G2	cytoplasmic vesicle membrane
GO:0033059	2.43176887518e-05	0.416666666667	AP1M1 AP1S2 AP1G1 KIF13A AP1S3	cellular pigmentation
GO:0012506	2.62706183155e-05	0.75	AFTPH AP1M2 AP1M1 KIF13A AP1G1 SYNRG AP1S3 AP1S2 AP1G2	vesicle membrane
GO:1903232	3.96119656039e-05	0.333333333333	AP1M1 AP1G1 AP1S2 AP1S3	melanosome assembly
GO:0060155	7.7374519929e-05	0.333333333333	AP1M1 AP1G1 AP1S2 AP1S3	platelet dense granule organization
GO:0043473	0.000104242978336	0.416666666667	AP1M1 AP1S2 AP1G1 KIF13A AP1S3	pigmentation
REAC:R-HSA-162906	0.000149177261407	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	HIV Infection
CORUM:7476	0.000225350794349	0.166666666667	AP1M1 AP1G2	AP1B1-AP1G2-AP1M-1AP1S1 complex
GO:0016192	0.000660666889787	0.75	AP1M1 AP1M2 KIF13A HEATR5B AP1AR AP1S3 AP1G1 AP1S2 AP1G2	vesicle-mediated transport
REAC:R-HSA-199991	0.000726083969512	0.5	AP1M1 AP1G2 AP1G1 AP1S3 AP1S2 AP1M2	Membrane Trafficking
GO:0033363	0.000947197717474	0.333333333333	AP1M1 AP1G1 AP1S2 AP1S3	secretory granule organization
REAC:R-HSA-5653656	0.000995748522715	0.5	AP1M1 AP1G2 AP1G1 AP1S3 AP1S2 AP1M2	Vesicle-mediated transport
GO:0098796	0.00484171554654	0.666666666667	AFTPH AP1M2 AP1M1 AP1G1 SYNRG AP1S3 AP1S2 AP1G2	membrane protein complex
GO:0051649	0.00514237157526	0.75	AP1M1 AP1G2 AFTPH HEATR5B KIF13A SYNRG AP1AR AP1G1 AP1M2	establishment of localization in cell
GO:0006810	0.00551263924131	0.916666666667	AP1M1 AP1G2 AFTPH HEATR5B KIF13A SYNRG AP1AR AP1S3 AP1G1 AP1S2 AP1M2	transport
GO:0098588	0.00740075298216	0.75	AFTPH AP1M2 AP1M1 KIF13A AP1G1 SYNRG AP1S3 AP1S2 AP1G2	bounding membrane of organelle
GO:0031982	0.0120959571785	0.916666666667	AP1M1 AP1G2 AFTPH HEATR5B KIF13A SYNRG AP1AR AP1S3 AP1G1 AP1S2 AP1M2	vesicle
GO:0051234	0.0147354901035	0.916666666667	AP1M1 AP1G2 AFTPH HEATR5B KIF13A SYNRG AP1AR AP1S3 AP1G1 AP1S2 AP1M2	establishment of localization
GO:0046907	0.0165269514036	0.666666666667	AP1M1 AP1G2 AFTPH HEATR5B KIF13A SYNRG AP1AR AP1G1	intracellular transport
GO:0000139	0.0172537274781	0.5	AP1M1 AP1G2 AP1G1 AP1S3 AP1S2 AP1M2	Golgi membrane
REAC:R-HSA-1280218	0.0314321021618	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	Adaptive Immune System
GO:0051641	0.031600671941	0.833333333333	AP1M1 AP1G2 AFTPH HEATR5B KIF13A SYNRG AP1AR AP1S3 AP1G1 AP1M2	cellular localization
GO:0006892	0.0398414672766	0.333333333333	AP1AR AP1G1 KIF13A AP1G2	post-Golgi vesicle-mediated transport
REAC:R-HSA-9824446	0.0411802982613	0.416666666667	AP1M1 AP1S2 AP1G1 AP1M2 AP1S3	Viral Infection Pathways

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
AP1S2	AP1G2	1.0	0.104	structurally_consistent (dimer)
AP1M2	AP1G1	1.0	0.068	mixed_interface
AP1M1	AP1S2	1.0	0.28	mutually_exclusive (O43747) structurally_consistent (dimer)
AP1S2	AP1G1	1.0	0.226	structurally_consistent (dimer)
AP1M1	AP1G1	1.0	0.538	structurally_consistent (Q10567) structurally_consistent (dimer)
AP1S2	HEATR5B	1.0	0.114
AP1G2	AP1M2	0.999	0.072	structurally_consistent (dimer)
AP1S2	AP1AR	0.999	0.052
AP1S2	AFTPH	0.999	0.072
AP1S2	SYNRG	0.999	0.152
SYNRG	AFTPH	0.999	0.126
HEATR5B	AP1S3	0.999	0.032
AP1S3	AP1G1	0.999	0.188	structurally_consistent (dimer)
AP1S2	AP1M2	0.999	0.174	mutually_exclusive (O75843)
AP1M2	AP1S3	0.999	0.024
AP1M1	AP1S3	0.998	0.082	mutually_exclusive (O43747)
AFTPH	AP1S3	0.998	0.064
AP1M2	MEA1	0.998	0.068	mutually_exclusive (Q9BXS5) structurally_consistent (dimer)
KIF13A	AP1S3	0.997
AP1M1	MEA1	0.997	0.084	mutually_exclusive (Q9Y6Q5) structurally_consistent (dimer)
SYNRG	AP1S3	0.997	0.078
HEATR5B	AFTPH	0.995	0.326
AP1AR	AP1S3	0.994	0.096
HEATR5B	AP1G1	0.994	0.048
AP1G2	AP1G1	0.993	0.096	mutually_exclusive (Q9Y6Q5) structurally_consistent (dimer)
AP1S2	MEA1	0.992	0.038
AP1G2	AP1S3	0.991	0.046	structurally_consistent (dimer)
SYNRG	HEATR5B	0.991	0.125
HEATR5B	AP1G2	0.99	0.064
AP1S2	AP1S3	0.99	0.062
AFTPH	AP1G1	0.989	0.09
AP1M1	AP1G2	0.987	0.016	mutually_exclusive (P56377)
KIF13A	AP1M2	0.986
AP1M1	AFTPH	0.986	0.154
AP1M1	SYNRG	0.985	0.182
SYNRG	AP1G1	0.985	0.23
MEA1	AP1G1	0.984	0.076
AP1G2	AFTPH	0.979	0.06
MEA1	AP1S3	0.978	0.07
HEATR5B	AP1M2	0.953	0.086
AFTPH	AP1M2	0.951	0.044
SYNRG	AP1M2	0.951
KIF13A	AP1G1	0.95
SYNRG	AP1G2	0.947	0.222
AP1G2	MEA1	0.946	0.014
AP1M1	HEATR5B	0.943	0.14
AP1AR	SYNRG	0.933	0.088
AP1AR	AFTPH	0.918	0.086
AP1AR	AP1G1	0.916	0.112	structurally_consistent (Q9BXS5) structurally_consistent (dimer)
AP1M1	AP1M2	0.912	0.056	structurally_consistent (dimer)
AP1AR	HEATR5B	0.905	0.05
AP1M1	AP1AR	0.893	0.062	structurally_consistent (dimer)
AP1AR	AP1G2	0.893	0.06	structurally_consistent (O43747)
AP1S2	KIF13A	0.839
AFTPH	MEA1	0.822	0.078
AP1M1	KIF13A	0.797
KIF13A	HEATR5B	0.795
SYNRG	KIF13A	0.795
KIF13A	AFTPH	0.795
KIF13A	AP1G2	0.783
HEATR5B	MEA1	0.777	0.044
KIF13A	MEA1	0.726
SYNRG	MEA1	0.578	0.034
AP1AR	KIF13A	0.49
AP1AR	AP1M2	0.402	0.05	mutually_exclusive (Q9BXS5)
AP1AR	MEA1	0.178	0.062

Related Complexes

Genename	Complexes
SYNRG	huMAP3_03095.1 huMAP3_04311.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
KIF13A	huMAP3_03095.1 huMAP3_04311.1 huMAP3_04725.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11660.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
HEATR5B	huMAP3_03095.1 huMAP3_04311.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1G2	huMAP3_03095.1 huMAP3_04311.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1M1	huMAP3_00819.1 huMAP3_04311.1 huMAP3_04842.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AFTPH	huMAP3_03095.1 huMAP3_04311.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1M2	huMAP3_03095.1 huMAP3_04311.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
MEA1	huMAP3_03095.1 huMAP3_04311.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1S3	huMAP3_03095.1 huMAP3_04311.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1S2	huMAP3_01815.1 huMAP3_03095.1 huMAP3_04657.1 huMAP3_05576.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10289.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1G1	huMAP3_04311.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1AR	huMAP3_01815.1 huMAP3_03095.1 huMAP3_04657.1 huMAP3_05276.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_10289.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05843.1

Complex Portal: CPX-24282