hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05846.1
Complex Portal: CPX-15499
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| THOC5 | THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | 5 | UniProt NCBI |
| CASC3 | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | 5 | UniProt NCBI |
| VIRMA | Protein virilizer homolog | 5 | UniProt NCBI |
| NCBP3 | Nuclear cap-binding protein subunit 3 (Protein ELG) | 5 | UniProt NCBI |
| CCDC9 | Coiled-coil domain-containing protein 9 | 4 | UniProt NCBI |
| CHTOP | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | 5 | UniProt NCBI |
| ZC3H11A | Zinc finger CCCH domain-containing protein 11A | 5 | UniProt NCBI |
| EIF4A3 | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | 5 | UniProt NCBI |
| DDX39B | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72187 | 4.23101383174e-11 | 0.666666666667 | CASC3 CHTOP DDX39B ZC3H11A EIF4A3 THOC5 | mRNA 3'-end processing |
| GO:0006406 | 4.93265138262e-11 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | mRNA export from nucleus |
| GO:0051028 | 9.3235679507e-11 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | mRNA transport |
| REAC:R-HSA-73856 | 9.90258371237e-11 | 0.666666666667 | CASC3 CHTOP DDX39B ZC3H11A EIF4A3 THOC5 | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-159236 | 1.90856243268e-10 | 0.666666666667 | CASC3 CHTOP DDX39B ZC3H11A EIF4A3 THOC5 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| GO:0006405 | 3.11910165035e-10 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | RNA export from nucleus |
| REAC:R-HSA-72202 | 4.03967603927e-10 | 0.666666666667 | CASC3 CHTOP DDX39B ZC3H11A EIF4A3 THOC5 | Transport of Mature Transcript to Cytoplasm |
| GO:0050658 | 1.64345438119e-09 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | RNA transport |
| GO:0050657 | 1.64345438119e-09 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | nucleic acid transport |
| GO:0051236 | 2.00486343699e-09 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | establishment of RNA localization |
| GO:0006403 | 1.12739924653e-08 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | RNA localization |
| GO:0051168 | 1.24750341788e-08 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | nuclear export |
| GO:0015931 | 1.75820858124e-08 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | nucleobase-containing compound transport |
| GO:0006913 | 5.4786238468e-07 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | nucleocytoplasmic transport |
| GO:0051169 | 5.4786238468e-07 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | nuclear transport |
| REAC:R-HSA-72203 | 7.80806320933e-07 | 0.666666666667 | CASC3 CHTOP DDX39B ZC3H11A EIF4A3 THOC5 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0000346 | 1.09198397762e-06 | 0.444444444444 | DDX39B ZC3H11A THOC5 CHTOP | transcription export complex |
| KEGG:03013 | 1.33275465027e-05 | 0.444444444444 | DDX39B EIF4A3 THOC5 CASC3 | Nucleocytoplasmic transport |
| CORUM:772 | 2.73623797451e-05 | 0.222222222222 | CASC3 EIF4A3 | EIF4A3-MLN51 complex |
| GO:0003723 | 3.31751333813e-05 | 1.0 | VIRMA CHTOP EIF4A3 DDX39B THOC5 CCDC9 ZC3H11A NCBP3 CASC3 | RNA binding |
| CORUM:351 | 7.28748929384e-05 | 0.444444444444 | DDX39B EIF4A3 THOC5 VIRMA | Spliceosome |
| CORUM:769 | 0.000164069436391 | 0.222222222222 | CASC3 EIF4A3 | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:754 | 0.000164069436391 | 0.222222222222 | CASC3 EIF4A3 | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14) |
| CORUM:744 | 0.000164069436391 | 0.222222222222 | CASC3 EIF4A3 | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:740 | 0.000164069436391 | 0.222222222222 | CASC3 EIF4A3 | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| REAC:R-HSA-8953854 | 0.000181368858283 | 0.666666666667 | CASC3 CHTOP DDX39B ZC3H11A EIF4A3 THOC5 | Metabolism of RNA |
| CORUM:755 | 0.000273361732609 | 0.222222222222 | CASC3 EIF4A3 | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM) |
| CORUM:770 | 0.000573693030134 | 0.222222222222 | DDX39B THOC5 | TREX complex |
| CORUM:785 | 0.000573693030134 | 0.222222222222 | DDX39B EIF4A3 | Exon junction complex |
| KEGG:03015 | 0.000965229215008 | 0.333333333333 | DDX39B CASC3 EIF4A3 | mRNA surveillance pathway |
| REAC:R-HSA-73857 | 0.00367767854286 | 0.666666666667 | CASC3 CHTOP DDX39B ZC3H11A EIF4A3 THOC5 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.00759942737987 | 0.666666666667 | CASC3 CHTOP DDX39B ZC3H11A EIF4A3 THOC5 | Gene expression (Transcription) |
| GO:0035145 | 0.00915637133828 | 0.333333333333 | CCDC9 CASC3 EIF4A3 | exon-exon junction complex |
| GO:0003676 | 0.0151133869702 | 1.0 | VIRMA CHTOP EIF4A3 DDX39B THOC5 CCDC9 ZC3H11A NCBP3 CASC3 | nucleic acid binding |
| GO:0071705 | 0.0181572644288 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | nitrogen compound transport |
| GO:0046907 | 0.0187458905152 | 0.777777777778 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A NCBP3 THOC5 | intracellular transport |
| GO:0140513 | 0.0219388544585 | 0.777777777778 | CASC3 CHTOP DDX39B ZC3H11A CCDC9 EIF4A3 THOC5 | nuclear protein-containing complex |
| HPA:0330222 | 0.0234578036135 | 0.888888888889 | CASC3 CHTOP EIF4A3 DDX39B ZC3H11A CCDC9 NCBP3 VIRMA | oral mucosa; squamous epithelial cells[>=Medium] |
| HPA:0630053 | 0.0271096309045 | 0.555555555556 | DDX39B ZC3H11A EIF4A3 NCBP3 CHTOP | cervix; glandular cells[High] |
| HPA:0490693 | 0.0300756850149 | 0.444444444444 | DDX39B EIF4A3 NCBP3 CHTOP | smooth muscle; smooth muscle cells[High] |
| HPA:0380513 | 0.0323609875813 | 0.555555555556 | DDX39B ZC3H11A EIF4A3 NCBP3 CHTOP | placenta; decidual cells[High] |
| HPA:0460662 | 0.0395781366172 | 0.777777777778 | CASC3 CHTOP DDX39B ZC3H11A CCDC9 NCBP3 VIRMA | skin 1; keratinocytes[>=Medium] |
| REAC:R-HSA-72163 | 0.0479913936721 | 0.333333333333 | DDX39B CASC3 EIF4A3 | mRNA Splicing - Major Pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CCDC9 | EIF4A3 | 1.0 | 0.1 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
| DDX39B | THOC5 | 1.0 | 0.356 |
structurally_consistent (Q8NI27)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
| CCDC9 | DDX39B | 1.0 | 0.092 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CCDC9 | THOC5 | 0.999 | 0.042 |
mutually_exclusive (Q6I9Y2)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| THOC5 | NCBP3 | 0.999 | 0.392 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| DDX39B | NCBP3 | 0.998 | 0.208 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| CCDC9 | NCBP3 | 0.998 | 0.104 |
mutually_exclusive (P61326)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZC3H11A | THOC5 | 0.998 | 0.362 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| CHTOP | DDX39B | 0.998 | 0.684 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| ZC3H11A | NCBP3 | 0.997 | 0.222 |
mutually_exclusive (Q96J01)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| CHTOP | NCBP3 | 0.997 | 0.208 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CCDC9 | ZC3H11A | 0.996 | 0.046 |
mutually_exclusive (P38919)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZC3H11A | DDX39B | 0.996 | 0.308 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| CCDC9 | CASC3 | 0.995 | 0.15 |
mutually_exclusive (P38919)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EIF4A3 | ZC3H11A | 0.995 | 0.394 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
| ZC3H11A | VIRMA | 0.995 | 0.342 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CHTOP | THOC5 | 0.993 | 0.366 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () fraction | |
| CHTOP | CCDC9 | 0.991 | 0.028 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| CHTOP | ZC3H11A | 0.991 | 0.346 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only | |
| EIF4A3 | DDX39B | 0.985 | 0.698 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| EIF4A3 | CASC3 | 0.984 | 0.474 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| CHTOP | EIF4A3 | 0.977 | 0.36 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| EIF4A3 | NCBP3 | 0.974 | 0.408 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EIF4A3 | THOC5 | 0.967 | 0.514 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| VIRMA | THOC5 | 0.93 | 0.576 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| ZC3H11A | CASC3 | 0.866 | 0.4999 |
mutually_exclusive (P38919)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CHTOP | VIRMA | 0.754 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| NCBP3 | CASC3 | 0.58 | 0.435818181818 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| DDX39B | CASC3 | 0.552 | 0.602 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CHTOP | CASC3 | 0.432 | 0.32 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| DDX39B | VIRMA | 0.429 | 0.85 | hein_WMM youn () bioplex3_WMM youn_WMM WMM_only | |
| VIRMA | NCBP3 | 0.191 | 0.262 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| CCDC9 | VIRMA | 0.191 | 0.146 | hein_WMM bioplex3_WMM youn_WMM fraction | |
| VIRMA | CASC3 | 0.145 | 0.252666666667 | bioplex3_WMM youn_WMM WMM_only | |
| EIF4A3 | VIRMA | 0.027 | 0.728 | hein_WMM youn () bioplex_WMM Guru bioplex3_WMM youn_WMM fraction | |
| THOC5 | CASC3 | 0.01 | 0.304 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes