hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05849.1

Complex Portal: CPX-15449

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
AP2M1	AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)	5	UniProt NCBI
RALBP1	RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1)	5	UniProt NCBI
AP2S1	AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)	5	UniProt NCBI
REPS1	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)	5	UniProt NCBI
CLINT1	Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)	5	UniProt NCBI
AP2A2	AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)	5	UniProt NCBI
ITSN2	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)	5	UniProt NCBI
ARFGAP1	ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)	5	UniProt NCBI
AAGAB	Alpha- and gamma-adaptin-binding protein p34	5	UniProt NCBI
AAK1	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)	5	UniProt NCBI
EPS15L1	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	5	UniProt NCBI
EPS15	Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)	5	UniProt NCBI
NECAP1	Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1)	4	UniProt NCBI
AP2B1	AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)	5	UniProt NCBI
CCDC32	Coiled-coil domain-containing protein 32	5	UniProt NCBI
NECAP2	Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2)	4	UniProt NCBI
FCHO2	F-BAR domain only protein 2	5	UniProt NCBI
ITSN1	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)	5	UniProt NCBI
AP2A1	AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)	5	UniProt NCBI
REPS2	RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2)	5	UniProt NCBI
STON2	Stonin-2 (Stoned B)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8856825	1.42099234599e-29	0.761904761905	NECAP1 NECAP2 AP2A2 AAK1 ITSN2 STON2 ITSN1 AP2M1 EPS15 FCHO2 REPS2 AP2A1 EPS15L1 AP2S1 AP2B1 REPS1	Cargo recognition for clathrin-mediated endocytosis
REAC:R-HSA-8856828	1.48896060446e-29	0.809523809524	NECAP1 NECAP2 AP2A2 AAK1 ARFGAP1 STON2 ITSN1 AP2M1 EPS15 FCHO2 ITSN2 AP2A1 EPS15L1 REPS2 AP2S1 AP2B1 REPS1	Clathrin-mediated endocytosis
GO:0005905	5.76719910504e-28	0.666666666667	NECAP2 AP2A2 AAK1 CCDC32 STON2 ITSN1 AP2M1 EPS15 FCHO2 AP2A1 REPS1 AP2S1 AP2B1 EPS15L1	clathrin-coated pit
GO:0006897	1.6797922216e-22	0.904761904762	NECAP2 CCDC32 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 STON2 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 RALBP1 REPS2 AP2S1 AP2B1 AP2A2	endocytosis
REAC:R-HSA-199991	1.411539097e-20	0.857142857143	NECAP1 NECAP2 AP2A2 AAK1 ITSN2 STON2 CLINT1 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 EPS15L1 REPS2 AP2S1 AP2B1 REPS1	Membrane Trafficking
GO:0098657	3.01717328551e-20	0.904761904762	NECAP2 CCDC32 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 STON2 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 RALBP1 REPS2 AP2S1 AP2B1 AP2A2	import into cell
REAC:R-HSA-5653656	3.78403221853e-20	0.857142857143	NECAP1 NECAP2 AP2A2 AAK1 ITSN2 STON2 CLINT1 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 EPS15L1 REPS2 AP2S1 AP2B1 REPS1	Vesicle-mediated transport
GO:0030118	1.79079520867e-19	0.52380952381	NECAP2 AP2A2 NECAP1 STON2 CLINT1 AP2M1 EPS15 AP2A1 AP2S1 AP2B1 EPS15L1	clathrin coat
GO:0072583	3.37150831146e-19	0.52380952381	STON2 AAK1 AP2A2 AP2B1 ITSN2 ITSN1 AP2M1 CCDC32 AP2A1 AP2S1 FCHO2	clathrin-dependent endocytosis
GO:0016192	2.72665749437e-17	0.952380952381	NECAP1 NECAP2 CCDC32 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 STON2 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 RALBP1 REPS2 AP2S1 AP2B1 AP2A2	vesicle-mediated transport
GO:0030132	9.74328699063e-17	0.380952380952	STON2 EPS15L1 AP2B1 AP2M1 EPS15 AP2A1 AP2S1 AP2A2	clathrin coat of coated pit
GO:0030125	1.73412522683e-15	0.428571428571	NECAP2 AP2A2 AP2M1 STON2 CLINT1 NECAP1 AP2A1 AP2S1 AP2B1	clathrin vesicle coat
GO:0030117	2.90314236445e-15	0.52380952381	NECAP2 AP2A2 NECAP1 STON2 CLINT1 AP2M1 EPS15 AP2A1 AP2S1 AP2B1 EPS15L1	membrane coat
GO:0048475	2.90314236445e-15	0.52380952381	NECAP2 AP2A2 NECAP1 STON2 CLINT1 AP2M1 EPS15 AP2A1 AP2S1 AP2B1 EPS15L1	coated membrane
GO:0006898	2.17974935461e-13	0.571428571429	STON2 AP2A2 AAK1 ITSN2 ITSN1 AP2M1 EPS15 FCHO2 CCDC32 AP2A1 AP2S1 AP2B1	receptor-mediated endocytosis
GO:0030136	9.3488966704e-13	0.52380952381	NECAP2 AAK1 AP2A2 AP2M1 FCHO2 STON2 CLINT1 NECAP1 AP2A1 AP2S1 AP2B1	clathrin-coated vesicle
GO:0030120	1.52577201862e-12	0.428571428571	NECAP2 AP2A2 AP2M1 STON2 CLINT1 NECAP1 AP2A1 AP2S1 AP2B1	vesicle coat
GO:0030122	5.60867694166e-12	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	AP-2 adaptor complex
GO:0030128	5.60867694166e-12	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	clathrin coat of endocytic vesicle
REAC:R-HSA-182218	2.46206233005e-11	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Nef Mediated CD8 Down-regulation
GO:0030135	1.25774059359e-10	0.52380952381	NECAP2 AAK1 AP2A2 AP2M1 FCHO2 STON2 CLINT1 NECAP1 AP2A1 AP2S1 AP2B1	coated vesicle
GO:0030665	1.43559328133e-10	0.428571428571	NECAP2 AP2A2 AP2M1 STON2 CLINT1 NECAP1 AP2A1 AP2S1 AP2B1	clathrin-coated vesicle membrane
REAC:R-HSA-167590	1.47454210539e-10	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Nef Mediated CD4 Down-regulation
GO:0035615	5.98360607731e-10	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	clathrin adaptor activity
GO:0099003	6.38705111442e-10	0.428571428571	STON2 FCHO2 AP2B1 ITSN2 ITSN1 AP2M1 AP2A1 AP2S1 AP2A2	vesicle-mediated transport in synapse
REAC:R-HSA-177504	9.24319349773e-10	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Retrograde neurotrophin signalling
GO:0140312	9.96389708894e-10	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	cargo adaptor activity
REAC:R-HSA-5140745	1.50064786318e-09	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
WP:WP437	1.63832931662e-09	0.380952380952	EPS15L1 AP2B1 AP2M1 EPS15 REPS2 AP2A1 AP2S1 RALBP1	EGF EGFR signaling pathway
GO:0006810	2.89461558564e-09	0.952380952381	NECAP1 NECAP2 CCDC32 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 STON2 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 RALBP1 REPS2 AP2S1 AP2B1 AP2A2	transport
REAC:R-HSA-5099900	3.49512175322e-09	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	WNT5A-dependent internalization of FZD4
GO:0030131	3.68594697472e-09	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	clathrin adaptor complex
GO:0140239	3.84081723488e-09	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	postsynaptic endocytosis
GO:0098884	3.84081723488e-09	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	postsynaptic neurotransmitter receptor internalization
REAC:R-HSA-8866427	5.07917237544e-09	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	VLDLR internalisation and degradation
GO:0140238	9.05610696399e-09	0.333333333333	STON2 FCHO2 AP2B1 ITSN2 ITSN1 AP2M1 AP2S1	presynaptic endocytosis
GO:0048488	9.05610696399e-09	0.333333333333	STON2 FCHO2 AP2B1 ITSN2 ITSN1 AP2M1 AP2S1	synaptic vesicle endocytosis
REAC:R-HSA-8964038	9.94480867767e-09	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	LDL clearance
GO:0030662	1.09139669645e-08	0.428571428571	NECAP2 AP2A2 AP2M1 STON2 CLINT1 NECAP1 AP2A1 AP2S1 AP2B1	coated vesicle membrane
GO:0051234	1.76186020803e-08	0.952380952381	NECAP1 NECAP2 CCDC32 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 STON2 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 RALBP1 REPS2 AP2S1 AP2B1 AP2A2	establishment of localization
WP:WP4159	1.88060078929e-08	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	GABA receptor signaling
REAC:R-HSA-164938	2.3554285134e-08	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
KEGG:04144	3.45630298645e-08	0.380952380952	EPS15L1 AP2B1 ARFGAP1 AP2M1 EPS15 AP2A1 AP2S1 AP2A2	Endocytosis
GO:0036465	3.50763968054e-08	0.333333333333	STON2 FCHO2 AP2B1 ITSN2 ITSN1 AP2M1 AP2S1	synaptic vesicle recycling
REAC:R-HSA-164952	9.29354110939e-08	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	The role of Nef in HIV-1 replication and disease pathogenesis
GO:0099590	1.44193818565e-07	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	neurotransmitter receptor internalization
REAC:R-HSA-8964043	2.30764929541e-07	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Plasma lipoprotein clearance
GO:0030119	3.17492104877e-07	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	AP-type membrane coat adaptor complex
KEGG:04961	3.17841626891e-07	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Endocrine and other factor-regulated calcium reabsorption
GO:0051179	3.64847573871e-07	0.952380952381	NECAP1 NECAP2 CCDC32 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 STON2 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 RALBP1 REPS2 AP2S1 AP2B1 AP2A2	localization
WP:WP2267	4.18572726763e-07	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Synaptic vesicle pathway
REAC:R-HSA-2682334	4.21216085243e-07	0.285714285714	AP2A2 AP2B1 ITSN1 AP2M1 AP2A1 AP2S1	EPH-Ephrin signaling
KEGG:04721	1.11828556836e-06	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Synaptic vesicle cycle
REAC:R-HSA-3928665	1.23092556868e-06	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	EPH-ephrin mediated repulsion of cells
REAC:R-HSA-437239	1.55083010279e-06	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Recycling pathway of L1
GO:0036020	1.55139015372e-06	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	endolysosome membrane
GO:0099504	4.31852948756e-06	0.333333333333	STON2 FCHO2 AP2B1 ITSN2 ITSN1 AP2M1 AP2S1	synaptic vesicle cycle
REAC:R-HSA-174824	6.10039114537e-06	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Plasma lipoprotein assembly, remodeling, and clearance
GO:0030669	9.57899750381e-06	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	clathrin-coated endocytic vesicle membrane
GO:0036019	1.44979241307e-05	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	endolysosome
GO:0099072	3.04022028538e-05	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	regulation of postsynaptic membrane neurotransmitter receptor levels
GO:0045334	3.21995358467e-05	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	clathrin-coated endocytic vesicle
REAC:R-HSA-9679191	3.58099797706e-05	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Potential therapeutics for SARS
REAC:R-HSA-4086400	5.049161169e-05	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	PCP/CE pathway
CORUM:3231	6.82792716788e-05	0.0952380952381	STON2 EPS15	Eps15-stonin2 complex
REAC:R-HSA-187037	6.95880741409e-05	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Signaling by NTRK1 (TRKA)
REAC:R-HSA-373760	8.95265010236e-05	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	L1CAM interactions
REAC:R-HSA-166520	0.000156067232589	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Signaling by NTRKs
REAC:R-HSA-2132295	0.000177633935322	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	MHC class II antigen presentation
GO:0051649	0.000235934701524	0.619047619048	STON2 AP2A2 AP2B1 ITSN2 ITSN1 AP2M1 EPS15 FCHO2 AP2A1 REPS1 REPS2 AP2S1 EPS15L1	establishment of localization in cell
REAC:R-HSA-162909	0.000246830570495	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Host Interactions of HIV factors
REAC:R-HSA-3858494	0.000375008095949	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Beta-catenin independent WNT signaling
CORUM:247	0.000408965737855	0.0952380952381	AP2A1 RALBP1	RalBP1-CCNB1-AP2A-NUMB-EPN1 complex
REAC:R-HSA-9006934	0.000488808788219	0.333333333333	EPS15L1 AP2B1 AP2M1 EPS15 AP2A1 AP2S1 AP2A2	Signaling by Receptor Tyrosine Kinases
GO:0098796	0.000590085334093	0.52380952381	NECAP2 AP2A2 NECAP1 STON2 CLINT1 AP2M1 EPS15 AP2A1 AP2S1 AP2B1 EPS15L1	membrane protein complex
GO:0005829	0.000890711219933	0.904761904762	NECAP1 STON2 AAK1 REPS1 AAGAB ITSN2 EPS15L1 CLINT1 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 RALBP1 REPS2 AP2S1 AP2B1 AP2A2	cytosol
WP:WP4829	0.00112047839358	0.142857142857	AP2B1 AP2A2 AP2A1	mBDNF and proBDNF regulation of GABA neurotransmission
KEGG:05016	0.00198013327953	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Huntington disease
WP:WP4549	0.00202367002643	0.190476190476	AP2M1 AP2A1 AP2S1 AP2B1	Fragile X syndrome
GO:0097708	0.00212792542024	0.619047619048	NECAP1 NECAP2 AP2A2 AAK1 ITSN2 STON2 CLINT1 ITSN1 AP2M1 FCHO2 AP2A1 AP2S1 AP2B1	intracellular vesicle
GO:0030666	0.00214967825899	0.285714285714	STON2 AP2A2 AP2B1 AP2M1 AP2A1 AP2S1	endocytic vesicle membrane
GO:0098797	0.0025008394404	0.380952380952	STON2 EPS15L1 AP2B1 AP2M1 EPS15 AP2A1 AP2S1 AP2A2	plasma membrane protein complex
HPA:0100212	0.00270459743629	0.571428571429	AP2A2 AAK1 ARFGAP1 CLINT1 AAGAB EPS15 ITSN2 REPS1 EPS15L1 AP2A1 AP2B1 RALBP1	cerebral cortex; neuropil[>=Medium]
REAC:R-HSA-162906	0.0040450265062	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	HIV Infection
GO:0016020	0.00453346121796	0.952380952381	NECAP1 NECAP2 CCDC32 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 STON2 ITSN1 AP2M1 EPS15 FCHO2 ARFGAP1 AP2A1 RALBP1 REPS2 AP2S1 AP2B1 AP2A2	membrane
GO:0031623	0.00745072451483	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	receptor internalization
GO:0005886	0.0101886037575	0.761904761905	STON2 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 ITSN1 AP2M1 EPS15 FCHO2 REPS2 AP2A1 RALBP1 AP2S1 AP2B1 AP2A2	plasma membrane
REAC:R-HSA-422475	0.0142209023948	0.285714285714	AP2A2 AP2B1 ITSN1 AP2M1 AP2A1 AP2S1	Axon guidance
GO:0012505	0.0161568578969	0.761904761905	NECAP2 AP2A2 AAK1 ARFGAP1 STON2 CLINT1 ITSN1 AP2M1 EPS15 FCHO2 CCDC32 AP2A1 EPS15L1 AP2S1 AP2B1 REPS1	endomembrane system
REAC:R-HSA-195721	0.0167283227941	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	Signaling by WNT
GO:0051641	0.0169753060949	0.666666666667	STON2 AP2A2 AAK1 ITSN2 ITSN1 AP2M1 EPS15 FCHO2 REPS2 AP2A1 EPS15L1 AP2S1 AP2B1 REPS1	cellular localization
REAC:R-HSA-9675108	0.0174556219208	0.285714285714	AP2A2 AP2B1 ITSN1 AP2M1 AP2A1 AP2S1	Nervous system development
GO:0030659	0.0200289209857	0.428571428571	NECAP2 AP2A2 AP2M1 STON2 CLINT1 NECAP1 AP2A1 AP2S1 AP2B1	cytoplasmic vesicle membrane
GO:0012506	0.0229050523027	0.428571428571	NECAP2 AP2A2 AP2M1 STON2 CLINT1 NECAP1 AP2A1 AP2S1 AP2B1	vesicle membrane
GO:0048268	0.0362257557392	0.142857142857	FCHO2 AP2S1 EPS15	clathrin coat assembly
GO:0031503	0.0385055689972	0.238095238095	AP2M1 AP2A1 AP2S1 AP2B1 AP2A2	protein-containing complex localization
GO:0071944	0.0422851267117	0.761904761905	STON2 REPS1 AAK1 ITSN2 EPS15L1 CLINT1 ITSN1 AP2M1 EPS15 FCHO2 REPS2 AP2A1 RALBP1 AP2S1 AP2B1 AP2A2	cell periphery
GO:0016197	0.0447835273968	0.285714285714	REPS1 ITSN2 ITSN1 EPS15 REPS2 EPS15L1	endosomal transport

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
AP2A2	AP2M1	1.0	0.418	mixed_interface
RALBP1	REPS1	1.0	0.374	structurally_consistent (dimer)
AP2S1	AP2A1	1.0	0.71	structurally_consistent (dimer)
AP2B1	AP2A1	1.0	0.93	structurally_consistent (dimer)
AP2M1	EPS15	1.0	0.25
AP2A2	AP2B1	1.0	0.336153846154
AP2S1	AP2M1	1.0	0.706	mixed_interface
AP2S1	AAK1	1.0	0.132
RALBP1	REPS2	1.0	0.28	structurally_consistent (dimer)
AP2B1	AP2S1	1.0	0.7	structurally_consistent (O95782)
NECAP2	AP2M1	1.0	0.1	structurally_consistent (dimer)
AP2A2	AP2S1	1.0	0.282	structurally_consistent (dimer)
ITSN1	AP2M1	1.0
CCDC32	AP2S1	1.0	0.13	structurally_consistent (dimer)
AP2M1	AAK1	1.0	0.224
AP2S1	EPS15	1.0	0.104	structurally_consistent (dimer)
AP2B1	EPS15	1.0	0.186
AP2B1	AP2M1	1.0	0.826	structurally_consistent (dimer)
AP2B1	NECAP2	1.0	0.09	mutually_exclusive (Q96CW1)
NECAP2	AP2A1	1.0	0.184
EPS15L1	AP2M1	1.0	0.186
EPS15L1	EPS15	0.999	0.182	mutually_exclusive (Q59EK9)
REPS1	AAK1	0.999	0.036
EPS15L1	AP2S1	0.999	0.222
EPS15L1	AP2A1	0.999	0.32
AP2A2	NECAP2	0.999	0.138416666667
ITSN1	AP2S1	0.999
CCDC32	AAGAB	0.999	0.11	mutually_exclusive (P53680)
AP2B1	ITSN1	0.999
NECAP2	AP2S1	0.999	0.076	structurally_consistent (dimer)
AP2M1	AP2A1	0.999	0.956	mutually_exclusive (P53680)
AP2A2	AAGAB	0.999	0.1305
EPS15L1	FCHO2	0.999	0.138
AP2B1	STON2	0.999	0.134
AP2A2	EPS15L1	0.999	0.313555555556
AP2B1	EPS15L1	0.999	0.446
EPS15	AP2A1	0.999	0.186
AP2S1	FCHO2	0.999	0.074	structurally_consistent (dimer)
AP2B1	FCHO2	0.999	0.114
AP2S1	REPS1	0.999	0.044
FCHO2	EPS15	0.998	0.142545454545
AAGAB	AP2S1	0.998	0.058	structurally_consistent (dimer)
EPS15L1	ITSN1	0.998
REPS1	EPS15	0.998	0.07
AP2A1	AAK1	0.998	0.158
FCHO2	AP2A1	0.998	0.188275862069
AP2S1	STON2	0.998	0.09
REPS2	REPS1	0.998	0.144	mutually_exclusive (Q15311)
AP2A2	CCDC32	0.998	0.13
RALBP1	AP2A1	0.998	0.14
AP2B1	AAK1	0.998	0.198
AAGAB	AP2A1	0.998	0.1085
REPS1	STON2	0.998	0.092
AP2M1	RALBP1	0.997	0.116	structurally_consistent (dimer)
AP2B1	REPS1	0.997	0.152
AP2M1	REPS1	0.997	0.13
FCHO2	STON2	0.997	0.066
AP2A1	STON2	0.997	0.162
ITSN2	EPS15L1	0.997	0.118
EPS15	AAK1	0.996	0.052
ITSN2	AP2M1	0.996	0.166
REPS1	AP2A1	0.996	0.112
CLINT1	AAK1	0.996	0.11
AP2A2	EPS15	0.996	0.218
NECAP2	NECAP1	0.996	0.076
EPS15	STON2	0.995	0.11
AP2B1	CLINT1	0.995	0.268
RALBP1	AAK1	0.995	0.154
AP2A2	AP2A1	0.994	0.3585
CCDC32	AP2A1	0.994	0.132
AP2M1	STON2	0.994	0.138
AP2S1	RALBP1	0.993	0.204
ARFGAP1	AP2A1	0.993	0.186
CLINT1	AP2A1	0.992	0.224
AP2M1	NECAP1	0.99	0.158	structurally_consistent (dimer)
REPS1	CLINT1	0.99	0.156
AAGAB	AP2M1	0.99	0.086	mutually_exclusive (P53680)
AP2B1	NECAP1	0.989	0.108
CCDC32	AP2M1	0.989	0.104	mutually_exclusive (P53680)
NECAP1	REPS1	0.988	0.09
FCHO2	AP2M1	0.987	0.104	structurally_consistent (dimer)
RALBP1	EPS15	0.986	0.09
FCHO2	NECAP1	0.985	0.102
EPS15L1	RALBP1	0.985	0.126
AP2B1	RALBP1	0.985	0.124	mutually_exclusive (Q96CW1)
ITSN2	ITSN1	0.985
ITSN2	AP2S1	0.982	0.084
AP2A2	STON2	0.982	0.166
AP2B1	AAGAB	0.981	0.13
RALBP1	STON2	0.98	0.138
AP2B1	ARFGAP1	0.98	0.196
FCHO2	AAK1	0.98	0.028
AP2M1	CLINT1	0.979	0.148
AP2A2	ARFGAP1	0.979	0.244857142857
AP2A2	RALBP1	0.978	0.168
NECAP1	CLINT1	0.977	0.136
AP2A2	ITSN1	0.976
NECAP1	AAK1	0.976	0.09
ITSN2	AP2A1	0.975	0.18
ITSN1	RALBP1	0.975
REPS2	AAK1	0.975	0.0945
AP2B1	CCDC32	0.974	0.06
NECAP1	STON2	0.97	0.108
CLINT1	EPS15	0.97	0.252
EPS15L1	STON2	0.97	0.122
AP2M1	ARFGAP1	0.968	0.118
NECAP1	EPS15	0.965	0.146
CLINT1	STON2	0.964	0.1
FCHO2	REPS1	0.964	0.04
AP2A2	ITSN2	0.963	0.36
RALBP1	CLINT1	0.962	0.11
AP2A2	FCHO2	0.959	0.146
ITSN1	EPS15	0.959
ITSN1	STON2	0.957
ITSN2	AP2B1	0.957	0.082
ITSN1	AP2A1	0.955
STON2	AAK1	0.955	0.074
AP2A2	AAK1	0.953	0.258
EPS15L1	AAK1	0.953	0.122
FCHO2	RALBP1	0.947	0.078
ITSN2	EPS15	0.935	0.15
ITSN2	FCHO2	0.932	0.052
NECAP2	AAK1	0.929	0.052
AP2A2	REPS1	0.928	0.288079365079
NECAP2	EPS15L1	0.927	0.096
EPS15L1	REPS1	0.927	0.112	mutually_exclusive (Q59EK9)
NECAP1	RALBP1	0.924	0.142	mutually_exclusive (Q96CW1)
AP2S1	CLINT1	0.923	0.282
ITSN1	REPS1	0.922
NECAP2	ITSN1	0.913
ITSN1	AAK1	0.905
NECAP1	AP2A1	0.898	0.168	mutually_exclusive (P53680)
NECAP2	REPS1	0.847	0.04
NECAP2	RALBP1	0.846	0.138	mutually_exclusive (Q96CW1)
ITSN1	FCHO2	0.831
AP2S1	REPS2	0.824	0.12	structurally_consistent (dimer)
AP2A2	CLINT1	0.817	0.106
NECAP2	EPS15	0.81	0.17
AP2S1	ARFGAP1	0.784	0.036
NECAP2	FCHO2	0.761	0.042	structurally_consistent (Q96CW1)
AP2M1	REPS2	0.747	0.138
AAGAB	FCHO2	0.702	0.04
AAGAB	ITSN1	0.656
CCDC32	ITSN1	0.617
CCDC32	AAK1	0.617	0.072
AP2S1	NECAP1	0.615	0.082	structurally_consistent (dimer)
ITSN2	STON2	0.595	0.1
CCDC32	FCHO2	0.572	0.052
CCDC32	EPS15	0.563	0.026
AAGAB	AAK1	0.517	0.066
NECAP2	STON2	0.487	0.064
CCDC32	EPS15L1	0.475	0.202
AP2A2	NECAP1	0.475	0.16	mutually_exclusive (P53680)
EPS15L1	NECAP1	0.43	0.158
AAGAB	EPS15	0.427	0.038
AAGAB	EPS15L1	0.415	0.066
ITSN1	NECAP1	0.36
ITSN2	NECAP1	0.353	0.092
FCHO2	CLINT1	0.324	0.144
CCDC32	STON2	0.305	0.06
AAGAB	RALBP1	0.24	0.034
ITSN2	RALBP1	0.231	0.07
CCDC32	REPS1	0.209	0.094
AAGAB	NECAP2	0.18	0.03	mutually_exclusive (P53680)
CCDC32	NECAP2	0.172	0.086	mutually_exclusive (P53680)
EPS15L1	CLINT1	0.17	0.228
CCDC32	RALBP1	0.164	0.128
AAGAB	STON2	0.138	0.082
ITSN2	AAK1	0.121	0.074
AAGAB	NECAP1	0.102	0.118	mutually_exclusive (P53680)
AAGAB	REPS1	0.096	0.044
REPS2	CLINT1	0.081	0.18
NECAP1	REPS2	0.07	0.104
FCHO2	REPS2	0.068	0.056
REPS2	STON2	0.068	0.084
AP2B1	REPS2	0.063	0.14
AAGAB	CLINT1	0.057	0.068
AP2A2	REPS2	0.054	0.182
ITSN2	REPS1	0.037	0.042
REPS2	EPS15	0.036	0.186
ITSN1	REPS2	0.031
ITSN2	NECAP2	0.029	0.07
REPS2	AP2A1	0.028	0.15
ITSN2	CCDC32	0.024	0.05
ITSN2	ARFGAP1	0.023	0.172
ITSN1	CLINT1	0.022
ITSN2	AAGAB	0.02	0.042
ITSN2	REPS2	0.019	0.126
NECAP2	REPS2	0.018	0.076
ARFGAP1	EPS15	0.018	0.09
ITSN1	ARFGAP1	0.016
EPS15L1	REPS2	0.015	0.202
EPS15L1	ARFGAP1	0.015	0.077
NECAP2	CLINT1	0.015	0.084
ARFGAP1	CLINT1	0.013	0.116
REPS1	ARFGAP1	0.009	0.062
NECAP2	ARFGAP1	0.007	0.018
ARFGAP1	AAK1	0.007	0.048
REPS2	ARFGAP1	0.006	0.132
ARFGAP1	STON2	0.005	0.168
RALBP1	ARFGAP1	0.005	0.056
FCHO2	ARFGAP1	0.005	0.09
ITSN2	CLINT1	0.003	0.074

Related Complexes

Genename	Complexes
AP2M1	huMAP3_00631.1 huMAP3_02419.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
RALBP1	huMAP3_02704.1 huMAP3_02942.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11054.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
AP2S1	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
REPS1	huMAP3_04101.1 huMAP3_05849.1 huMAP3_08320.1 huMAP3_08553.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
CLINT1	huMAP3_05120.1 huMAP3_05849.1 huMAP3_06787.1 huMAP3_08320.1 huMAP3_08744.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
AP2A2	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11624.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
ITSN2	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
ARFGAP1	huMAP3_05105.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_08320.1 huMAP3_09403.1 huMAP3_10876.1 huMAP3_14934.1
AAGAB	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11624.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1 huMAP3_13969.1
AAK1	huMAP3_05849.1 huMAP3_07777.1 huMAP3_08320.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
EPS15L1	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
EPS15	huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
NECAP1	huMAP3_00819.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
AP2B1	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
CCDC32	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11624.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13969.1
NECAP2	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12582.1 huMAP3_12918.1
FCHO2	huMAP3_00631.1 huMAP3_02419.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
ITSN1	huMAP3_00432.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
AP2A1	huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
REPS2	huMAP3_02704.1 huMAP3_02942.1 huMAP3_04101.1 huMAP3_05849.1 huMAP3_07777.1 huMAP3_08320.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_11054.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
STON2	huMAP3_05120.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05849.1

Complex Portal: CPX-15449