hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05899.1
Complex Portal: CPX-15742
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | 5 | UniProt NCBI |
| PAIP1 | Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1) | 5 | UniProt NCBI |
| MKRN3 | Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127) | 5 | UniProt NCBI |
| MKRN2 | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | 5 | UniProt NCBI |
| IREB2 | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | 5 | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | 5 | UniProt NCBI |
| PABPC1L | Polyadenylate-binding protein 1-like | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 0.0001112297655 | 0.428571428571 | ETF1 GSPT2 PAIP1 | Translation factors |
| KEGG:03015 | 0.000418965008626 | 0.428571428571 | ETF1 GSPT2 PABPC1L | mRNA surveillance pathway |
| GO:0003723 | 0.00365068293209 | 1.0 | MKRN3 PABPC1L PAIP1 MKRN2 IREB2 ETF1 GSPT2 | RNA binding |
| GO:0018444 | 0.0294899169624 | 0.285714285714 | ETF1 GSPT2 | translation release factor complex |
| CORUM:809 | 0.0499958217778 | 0.142857142857 | ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GSPT2 | MKRN3 | 0.994 | 0.064 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GSPT2 | IREB2 | 0.99 | 0.038 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GSPT2 | ETF1 | 0.987 | 0.686 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| MKRN2 | GSPT2 | 0.983 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PAIP1 | MKRN2 | 0.982 | 0.232 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| PAIP1 | MKRN3 | 0.978 | 0.07 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PAIP1 | GSPT2 | 0.961 | 0.246 |
mutually_exclusive (P0CB38)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| PAIP1 | IREB2 | 0.914 | 0.1124 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MKRN2 | IREB2 | 0.854 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKRN2 | MKRN3 | 0.561 | 0.134 | bioplex3_WMM WMM_only | |
| IREB2 | MKRN3 | 0.346 | 0.1 | bioplex3_WMM WMM_only | |
| MKRN2 | ETF1 | 0.025 | 0.13 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| IREB2 | ETF1 | 0.006 | 0.086 | bioplex3_WMM WMM_only | |
| ETF1 | MKRN3 | 0.006 | 0.038 | bioplex3_WMM WMM_only | |
| PAIP1 | ETF1 | 0.003 | 0.252 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes