hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05900.1
Complex Portal: CPX-15483
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TYMP | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | 5 | UniProt NCBI |
| SERPINB3 | Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1) | 5 | UniProt NCBI |
| S100A9 | Protein S100-A9 (Calgranulin-B) (Calprotectin L1H subunit) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9) | 5 | UniProt NCBI |
| CRABP2 | Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) | 5 | UniProt NCBI |
| LCN2 | Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25) | 5 | UniProt NCBI |
| ACP3 | Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39] | 5 | UniProt NCBI |
| GM2A | Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6799990 | 2.56314262819e-05 | 1.0 | LCN2 S100A9 | Metal sequestration by antimicrobial proteins |
| KEGG:04657 | 0.000475678926029 | 1.0 | LCN2 S100A9 | IL-17 signaling pathway |
| REAC:R-HSA-6803157 | 0.0027271837564 | 1.0 | LCN2 S100A9 | Antimicrobial peptides |
| CORUM:6826 | 0.0499419797295 | 0.5 | S100A9 | Calprotectin heterotetramer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LCN2 | GM2A | 0.994 | 0.054 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| SERPINB3 | LCN2 | 0.991 | 0.224 | bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only | |
| SERPINB3 | GM2A | 0.987 | 0.076 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| S100A9 | GM2A | 0.983 | 0.044 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| SERPINB3 | ACP3 | 0.977 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACP3 | GM2A | 0.975 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| CRABP2 | GM2A | 0.963 | 0.022 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| S100A9 | LCN2 | 0.962 | 0.228 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM treiber_WMM WMM_only | |
| S100A9 | ACP3 | 0.956 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| S100A9 | SERPINB3 | 0.955 | 0.227 | bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only | |
| TYMP | GM2A | 0.952 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| TYMP | CRABP2 | 0.951 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM | |
| CRABP2 | LCN2 | 0.942 | 0.104 | bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only | |
| CRABP2 | ACP3 | 0.942 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| LCN2 | ACP3 | 0.937 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | |
| TYMP | LCN2 | 0.922 | 0.222 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| TYMP | SERPINB3 | 0.914 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM | |
| TYMP | ACP3 | 0.904 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| TYMP | S100A9 | 0.883 | 0.232 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM | |
| CRABP2 | S100A9 | 0.825 | 0.024 | bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only | |
| CRABP2 | SERPINB3 | 0.559 | 0.062 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM WMM_only |
Related Complexes