hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05901.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
GNAI2	Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)	5	UniProt NCBI
PPY	Pancreatic polypeptide prohormone (PH) (Pancreatic polypeptide Y) (Obinepitide) [Cleaved into: Pancreatic polypeptide (HPP) (PP); Pancreatic icosapeptide (PI)]	5	UniProt NCBI
GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	5	UniProt NCBI
GNG7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	4	UniProt NCBI
RIC8A	Synembryn-A (Protein Ric-8A)	5	UniProt NCBI
GNA13	Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)	5	UniProt NCBI
GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-392518	1.04147201904e-10	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	Signal amplification
WP:WP35	7.17168374294e-09	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	G protein signaling pathways
REAC:R-HSA-392170	1.72490220596e-08	0.571428571429	GNG7 GNG5 GNAI2 GNG10	ADP signalling through P2Y purinoceptor 12
KEGG:04371	2.49924811665e-08	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	Apelin signaling pathway
REAC:R-HSA-400042	2.60340792443e-08	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Adrenaline,noradrenaline inhibits insulin secretion
REAC:R-HSA-428930	2.60340792443e-08	0.571428571429	GNG7 GNG5 GNG10 GNA13	Thromboxane signalling through TP receptor
GO:0005834	2.68699780911e-08	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	heterotrimeric G-protein complex
REAC:R-HSA-456926	6.24091028415e-08	0.571428571429	GNG7 GNG5 GNG10 GNA13	Thrombin signalling through proteinase activated receptors (PARs)
GO:1905360	7.1034375646e-08	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	GTPase complex
REAC:R-HSA-977444	1.4537101986e-07	0.571428571429	GNG7 GNG5 GNAI2 GNG10	GABA B receptor activation
REAC:R-HSA-991365	1.4537101986e-07	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Activation of GABAB receptors
REAC:R-HSA-418597	1.85951185977e-07	0.571428571429	GNG7 GNG5 GNAI2 GNG10	G alpha (z) signalling events
REAC:R-HSA-9660821	1.85951185977e-07	0.571428571429	GNG7 GNG5 GNAI2 GNG10	ADORA2B mediated anti-inflammatory cytokines production
REAC:R-HSA-9634597	2.09160668344e-07	0.571428571429	GNG7 GNG5 GNAI2 GNG10	GPER1 signaling
REAC:R-HSA-388396	3.1986029751e-07	0.857142857143	GNG10 GNG7 GNAI2 PPY GNG5 GNA13	GPCR downstream signalling
REAC:R-HSA-977443	3.59295142623e-07	0.571428571429	GNG7 GNG5 GNAI2 GNG10	GABA receptor activation
KEGG:05163	3.98585578918e-07	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	Human cytomegalovirus infection
REAC:R-HSA-372790	6.99645771378e-07	0.857142857143	GNG10 GNG7 GNAI2 PPY GNG5 GNA13	Signaling by GPCR
KEGG:04727	7.29232512751e-07	0.571428571429	GNG7 GNG5 GNAI2 GNG10	GABAergic synapse
KEGG:05032	7.74681871196e-07	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Morphine addiction
GO:0007186	8.51826169827e-07	1.0	GNG10 GNG7 GNAI2 PPY GNG5 RIC8A GNA13	G protein-coupled receptor signaling pathway
GO:0031234	1.02626003625e-06	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	extrinsic component of cytoplasmic side of plasma membrane
KEGG:04713	1.03451366218e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Circadian entrainment
REAC:R-HSA-418594	1.26149297337e-06	0.714285714286	GNG10 GNG7 GNG5 GNAI2 PPY	G alpha (i) signalling events
KEGG:04724	1.57924080729e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Glutamatergic synapse
KEGG:04726	1.83059822792e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Serotonergic synapse
REAC:R-HSA-9662851	1.97234251471e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Anti-inflammatory response favouring Leishmania parasite infection
REAC:R-HSA-416482	1.97234251471e-06	0.571428571429	GNG7 GNG5 GNG10 GNA13	G alpha (12/13) signalling events
REAC:R-HSA-9009391	1.97234251471e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Extra-nuclear estrogen signaling
REAC:R-HSA-9664433	1.97234251471e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Leishmania parasite growth and survival
KEGG:04725	2.31456287103e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Cholinergic synapse
REAC:R-HSA-422356	2.39259094536e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Regulation of insulin secretion
REAC:R-HSA-76002	2.73811952949e-06	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	Platelet activation, signaling and aggregation
REAC:R-HSA-111885	5.03005208045e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Opioid Signalling
KEGG:04926	5.06429922286e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Relaxin signaling pathway
KEGG:04728	5.25635682857e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Dopaminergic synapse
REAC:R-HSA-8964315	7.28267215104e-06	0.428571428571	GNG7 GNG10 GNG5	G beta:gamma signalling through BTK
REAC:R-HSA-392851	7.28267215104e-06	0.428571428571	GNG7 GNG10 GNG5	Prostacyclin signalling through prostacyclin receptor
KEGG:04723	7.4903203623e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Retrograde endocannabinoid signaling
REAC:R-HSA-418217	8.84142817265e-06	0.428571428571	GNG7 GNG10 GNG5	G beta:gamma signalling through PLC beta
REAC:R-HSA-500657	8.84142817265e-06	0.428571428571	GNG7 GNG10 GNG5	Presynaptic function of Kainate receptors
GO:0019897	9.20695458564e-06	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	extrinsic component of plasma membrane
REAC:R-HSA-163685	9.40454269709e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Integration of energy metabolism
REAC:R-HSA-418555	9.83039982557e-06	0.571428571429	GNG7 GNG5 GNAI2 GNG10	G alpha (s) signalling events
REAC:R-HSA-8964616	1.06075342669e-05	0.428571428571	GNG7 GNG10 GNG5	G beta:gamma signalling through CDC42
WP:WP3929	1.39029215533e-05	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Chemokine signaling pathway
KEGG:04062	1.4000550416e-05	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Chemokine signaling pathway
REAC:R-HSA-392451	1.72785870928e-05	0.428571428571	GNG7 GNG10 GNG5	G beta:gamma signalling through PI3Kgamma
KEGG:05034	1.85093627008e-05	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Alcoholism
REAC:R-HSA-451326	2.00026744108e-05	0.428571428571	GNG7 GNG10 GNG5	Activation of kainate receptors upon glutamate binding
REAC:R-HSA-418592	2.00026744108e-05	0.428571428571	GNG7 GNG10 GNG5	ADP signalling through P2Y purinoceptor 1
REAC:R-HSA-202040	2.00026744108e-05	0.428571428571	GNG7 GNG10 GNG5	G-protein activation
REAC:R-HSA-997272	2.29983491089e-05	0.428571428571	GNG7 GNG10 GNG5	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REAC:R-HSA-1296041	2.29983491089e-05	0.428571428571	GNG7 GNG10 GNG5	Activation of G protein gated Potassium channels
REAC:R-HSA-1296059	2.29983491089e-05	0.428571428571	GNG7 GNG10 GNG5	G protein gated Potassium channels
REAC:R-HSA-420092	2.29983491089e-05	0.428571428571	GNG7 GNG10 GNG5	Glucagon-type ligand receptors
KEGG:05200	2.69718257825e-05	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	Pathways in cancer
REAC:R-HSA-397795	3.79530741097e-05	0.428571428571	GNG7 GNG10 GNG5	G-protein beta:gamma signalling
REAC:R-HSA-1296065	3.79530741097e-05	0.428571428571	GNG7 GNG10 GNG5	Inwardly rectifying K+ channels
REAC:R-HSA-163359	3.79530741097e-05	0.428571428571	GNG7 GNG10 GNG5	Glucagon signaling in metabolic regulation
REAC:R-HSA-9824443	4.76192041812e-05	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Parasitic Infection Pathways
REAC:R-HSA-9658195	4.76192041812e-05	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Leishmania infection
KEGG:05170	5.22099499137e-05	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Human immunodeficiency virus 1 infection
REAC:R-HSA-432040	7.75332089956e-05	0.428571428571	GNG7 GNG10 GNG5	Vasopressin regulates renal water homeostasis via Aquaporins
GO:0019898	8.04804550787e-05	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	extrinsic component of membrane
GO:0009898	8.04804550787e-05	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	cytoplasmic side of plasma membrane
REAC:R-HSA-6814122	8.47845144152e-05	0.428571428571	GNG7 GNG10 GNG5	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
REAC:R-HSA-381676	8.47845144152e-05	0.428571428571	GNG7 GNG10 GNG5	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REAC:R-HSA-112314	8.69731520059e-05	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Neurotransmitter receptors and postsynaptic signal transmission
REAC:R-HSA-445717	9.24731829377e-05	0.428571428571	GNG7 GNG10 GNG5	Aquaporin-mediated transport
REAC:R-HSA-8939211	0.000163659671708	0.571428571429	GNG7 GNG5 GNAI2 GNG10	ESR-mediated signaling
REAC:R-HSA-109582	0.000225025549393	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	Hemostasis
GO:0098562	0.000225962421449	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	cytoplasmic side of membrane
REAC:R-HSA-112315	0.000237250215483	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Transmission across Chemical Synapses
REAC:R-HSA-4086398	0.00030234111687	0.428571428571	GNG7 GNG10 GNG5	Ca2+ pathway
REAC:R-HSA-500792	0.000383851273485	0.571428571429	GNG7 GNG5 PPY GNG10	GPCR ligand binding
REAC:R-HSA-9006931	0.000518975612289	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Signaling by Nuclear Receptors
REAC:R-HSA-1296071	0.000589010657253	0.428571428571	GNG7 GNG10 GNG5	Potassium Channels
REAC:R-HSA-373080	0.000644814393069	0.428571428571	GNG7 GNG10 GNG5	Class B/2 (Secretin family receptors)
REAC:R-HSA-418346	0.000766722633593	0.428571428571	GNG7 GNG10 GNG5	Platelet homeostasis
REAC:R-HSA-112316	0.00109485698971	0.571428571429	GNG7 GNG5 GNAI2 GNG10	Neuronal System
REAC:R-HSA-390466	0.00126637654584	0.428571428571	GNG7 GNG10 GNG5	Chaperonin-mediated protein folding
WP:WP536	0.00135826261108	0.428571428571	GNG7 GNAI2 GNG5	Calcium regulation in cardiac cells
REAC:R-HSA-391251	0.00160779946306	0.428571428571	GNG7 GNG10 GNG5	Protein folding
GO:0031681	0.00228108846854	0.428571428571	GNG7 GNG10 GNG5	G-protein beta-subunit binding
KEGG:05167	0.0026347269947	0.428571428571	GNG7 GNG10 GNG5	Kaposi sarcoma-associated herpesvirus infection
WP:WP4223	0.00306867539698	0.428571428571	GNG7 GNG10 GNG5	Ras signaling
KEGG:04014	0.00345545422147	0.428571428571	GNG7 GNG10 GNG5	Ras signaling pathway
REAC:R-HSA-416476	0.00465019583743	0.428571428571	GNG7 GNG10 GNG5	G alpha (q) signalling events
REAC:R-HSA-3858494	0.00520230847661	0.428571428571	GNG7 GNG10 GNG5	Beta-catenin independent WNT signaling
REAC:R-HSA-162582	0.00838328139233	0.857142857143	GNG10 GNG7 GNAI2 PPY GNG5 GNA13	Signal Transduction
KEGG:04730	0.0114560548	0.285714285714	GNAI2 GNA13	Long-term depression
KEGG:04151	0.0127794263112	0.428571428571	GNG7 GNG10 GNG5	PI3K-Akt signaling pathway
WP:WP3932	0.0145518366115	0.428571428571	GNG7 GNG10 GNG5	Focal adhesion PI3K Akt mTOR signaling pathway
GO:0098552	0.0157986239151	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	side of membrane
GO:0098797	0.0163912587278	0.714285714286	GNG5 GNG7 GNA13 GNAI2 GNG10	plasma membrane protein complex
WP:WP4172	0.0189167579285	0.428571428571	GNG7 GNG10 GNG5	PI3K Akt signaling pathway
WP:WP2032	0.0261327164033	0.285714285714	GNAI2 GNA13	Thyroid stimulating hormone TSH signaling pathway
KEGG:04928	0.0342858776489	0.285714285714	GNAI2 GNA13	Parathyroid hormone synthesis, secretion and action
KEGG:04611	0.047723469919	0.285714285714	GNAI2 GNA13	Platelet activation
CORUM:7172	0.0499958217778	0.142857142857	GNG7	GNAS-L-GNB3-GNG7 complex
CORUM:7189	0.0499958217778	0.142857142857	GNG10	GNAS-L-GNB3-GNG10 complex
CORUM:7167	0.0499958217778	0.142857142857	GNG5	GNAS-L-GNB3-GNG5 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
GNAI2	RIC8A	0.999	0.042	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM
GNG7	GNAI2	0.997	0.126	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GNA13	GNG10	0.997	0.238	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
GNA13	GNG5	0.997	0.08	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
GNG10	GNAI2	0.996	0.218	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GNG5	GNAI2	0.99	0.04	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GNG10	GNG7	0.986	0.104	bioplex_WMM bioplex3_WMM WMM_only
GNG10	GNG5	0.976	0.1	bioplex_WMM bioplex3_WMM WMM_only
GNG5	GNG7	0.976	0.026	bioplex_WMM bioplex3_WMM WMM_only
PPY	GNG10	0.97		bioplex3_WMM bioplex3_HCT116 WMM_only
GNG10	RIC8A	0.945	0.098	bioplex_WMM bioplex3_WMM WMM_only
GNG5	RIC8A	0.943	0.042	bioplex_WMM bioplex3_WMM WMM_only
GNG7	RIC8A	0.942	0.06	bioplex_WMM bioplex3_WMM WMM_only
GNA13	RIC8A	0.913	0.044	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
GNA13	GNG7	0.763	0.224	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
GNA13	GNAI2	0.747	0.374	bioplex_WMM bioplex3_WMM WMM_only
GNA13	PPY	0.039		bioplex3_HCT116 WMM_only
PPY	GNAI2	0.013		bioplex3_WMM bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
GNAI2	huMAP3_05473.1 huMAP3_05901.1 huMAP3_08591.1 huMAP3_08713.1 huMAP3_09165.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1
PPY	huMAP3_02905.1 huMAP3_03302.1 huMAP3_05901.1 huMAP3_09480.1 huMAP3_10824.1 huMAP3_11125.1 huMAP3_11173.1
GNG10	huMAP3_02905.1 huMAP3_05901.1 huMAP3_09480.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG7	huMAP3_03550.1 huMAP3_05901.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
RIC8A	huMAP3_05901.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNA13	huMAP3_02649.1 huMAP3_02905.1 huMAP3_03009.1 huMAP3_05901.1 huMAP3_09480.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG5	huMAP3_02905.1 huMAP3_05901.1 huMAP3_09480.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05901.1