hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05917.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCDHA4 | Protocadherin alpha-4 (PCDH-alpha-4) | 5 | UniProt NCBI |
| TCL1A | T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1) | 5 | UniProt NCBI |
| DNMT3A | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | 5 | UniProt NCBI |
| DNMT3B | DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) | 5 | UniProt NCBI |
| UFSP2 | Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) | 5 | UniProt NCBI |
| PCDHA1 | Protocadherin alpha-1 (PCDH-alpha-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3657 | 0.00171766688832 | 0.333333333333 | DNMT3A DNMT3B | Hematopoietic stem cell gene regulation by GABP alpha beta complex |
| WP:WP4288 | 0.00171766688832 | 0.333333333333 | DNMT3A DNMT3B | MTHFR deficiency |
| REAC:R-HSA-4655427 | 0.00270466310657 | 0.333333333333 | DNMT3A DNMT3B | SUMOylation of DNA methylation proteins |
| WP:WP241 | 0.00276984458443 | 0.333333333333 | DNMT3A DNMT3B | One carbon metabolism |
| GO:0090116 | 0.00702301080125 | 0.333333333333 | DNMT3A DNMT3B | C-5 methylation of cytosine |
| KEGG:00270 | 0.00746443583489 | 0.333333333333 | DNMT3A DNMT3B | Cysteine and methionine metabolism |
| WP:WP2525 | 0.0148188030846 | 0.333333333333 | DNMT3A DNMT3B | Trans sulfuration one carbon metabolism and related pathways |
| GO:0003886 | 0.0210651876021 | 0.333333333333 | DNMT3A DNMT3B | DNA (cytosine-5-)-methyltransferase activity |
| GO:0009008 | 0.0210651876021 | 0.333333333333 | DNMT3A DNMT3B | DNA-methyltransferase activity |
| GO:0032776 | 0.0210651876021 | 0.333333333333 | DNMT3A DNMT3B | DNA methylation on cytosine |
| REAC:R-HSA-5334118 | 0.0339259639772 | 0.333333333333 | DNMT3A DNMT3B | DNA methylation |
| REAC:R-HSA-9710421 | 0.0467439411123 | 0.333333333333 | DNMT3A DNMT3B | Defective pyroptosis |
| REAC:R-HSA-212300 | 0.0467439411123 | 0.333333333333 | DNMT3A DNMT3B | PRC2 methylates histones and DNA |
| CORUM:2650 | 0.0499436884912 | 0.166666666667 | DNMT3B | DNMT3B-DNMT3L complex |
| CORUM:2651 | 0.0499436884912 | 0.166666666667 | DNMT3A | DNMT3L-DNMT3A complex |
| CORUM:3849 | 0.0499436884912 | 0.166666666667 | TCL1A | TCL1 homotrimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TCL1A | DNMT3B | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PCDHA4 | PCDHA1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TCL1A | DNMT3A | 0.997 | 0.104 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| DNMT3A | DNMT3B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PCDHA4 | TCL1A | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PCDHA4 | DNMT3A | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PCDHA4 | DNMT3B | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCL1A | UFSP2 | 0.961 | 0.056 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| PCDHA4 | UFSP2 | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TCL1A | PCDHA1 | 0.902 | bioplex3_WMM WMM_only | |
| DNMT3A | PCDHA1 | 0.869 | bioplex3_WMM WMM_only | |
| DNMT3B | PCDHA1 | 0.768 | bioplex3_WMM WMM_only | |
| DNMT3B | UFSP2 | 0.633 | bioplex_WMM bioplex3_WMM WMM_only | |
| DNMT3A | UFSP2 | 0.615 | 0.042 | bioplex3_WMM WMM_only |
| UFSP2 | PCDHA1 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes